Geo-L: Topological Link Discovery for Geospatial Linked Data Made Easy

Geospatial linked data are an emerging domain, with growing interest in research and the industry. There is an increasing number of publicly available geospatial linked data resources, which can also be interlinked and easily integrated with private and industrial linked data on the web. The present paper introduces Geo-L, a system for the discovery of RDF spatial links based on topological relations. Experiments show that the proposed system improves state-of-the-art spatial linking processes in terms of mapping time and accuracy, as well as concerning resources retrieval efficiency and robustness

Time-resolved single-cell RNA-seq using metabolic RNA labelling

Single-cell RNA sequencing offers snapshots of whole transcriptomes but obscures the temporal RNA dynamics. Here we present single-cell metabolically labeled new RNA tagging sequencing (scNT-seq), a method for massively parallel analysis of newly transcribed and pre-existing mRNAs from the same cell. This droplet microfluidics-based method enables high-throughput chemical conversion on barcoded beads, efficiently marking newly transcribed mRNAs with T-to-C substitutions. Using scNT-seq, we jointly profiled new and old transcriptomes in ~55,000 single cells. These data revealed time-resolved transcription factor activities and cell-state trajectories at the single-cell level in response to neuronal activation. We further determined rates of RNA biogenesis and decay to uncover RNA regulatory strategies during stepwise conversion between pluripotent and rare totipotent two-cell embryo (2C)-like stem cell states. Finally, integrating scNT-seq with genetic perturbation identifies DNA methylcytosine dioxygenase as an epigenetic barrier into the 2C-like cell state. Time-resolved single-cell transcriptomic analysis thus opens new lines of inquiry regarding cell-type-specific RNA regulatory mechanisms

Unsupervised morphological analysis of small corpora: First experiments with Kilivila

Language documentation involves linguistic analysis of the collected material, which is typically done manually. Automatic methods for language processing usually require large corpora. The method presented in this paper uses techniques from bioinformatics and contextual information to morphologically analyze raw text corpora. This paper presents initial results of the method when applied on a small Kilivila corpus.National Foreign Language Resource Cente

A general method for creating a bilingual transliteration dictionary

Transliteration is the rendering in one language of terms from another language (and, possibly, another writing system), approximating spelling and/or phonetic equivalents between the two languages. A transliteration dictionary is a crucial resource for a variety of natural language applications, most notably machine translation. We describe a general method for creating bilingual transliteration dictionaries from Wikipedia article titles. The method can be applied to any language pair with Wikipedia presence, independently of the writing systems involved, and requires only a single simple resource that can be provided by any literate bilingual speaker. It was successfully applied to extract a Hebrew-English transliteration dictionary which, when incorporated in a machine translation system, indeed improved its performance. 1

Brain metastases: Not all tumors are created equal

Metastases are the main cause of death in cancer patients. In a recent issue of Cell, Gonzalez et al., 2022 analyze gene expression on the single-cell level in brain metastases from various primary tumors. By profiling metastatic tumor cells and their niche, they demonstrate distinctive and shared features across metastases