1,727 research outputs found
Spammer Detection on Online Social Networks
Twitter with its rising popularity as a micro-blogging website has inevitably attracted attention of spammers. Spammers use myriad of techniques to lure victims into clicking malicious URLs. In this thesis, we present several novel features capable of distinguishing spam accounts from legitimate accounts in real-time. The features exploit the behavioral and content entropy, bait-techniques, community-orientation, and profile characteristics of spammers. We then use supervised learning algorithms to generate models using the proposed features and show that our tool, spAmbush, can detect spammers in real-time. Our analysis reveals detection of more than 90% of spammers with less than five tweets and more than half with only a single tweet. Our feature computation has low latency and resource requirement. Our results show a 96% detection rate with only 0.01% false positive rate. We further cluster the unknown spammers to identify and understand the prevalent spam campaigns on Twitter
The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task
Dopaminergic brain circuits participate in emotional processing and impulsivity. The dopamine transporter (DAT) modulates dopamine reuptake. A variable number tandem repeat (VNTR) in the dopamine transporter gene (DAT1) affects DAT expression. The influence of DAT1 genotype on neural activation during emotional processing and impulse inhibition has not been examined. Forty-two healthy subjects were classified as 9DAT (n = 17) or 10DAT (n = 25) based on DAT1 genotype (9DAT = 9R/9R and 9R/10R; 10DAT = 10R/10R). Subjects underwent fMRI during non-emotional and emotional go/no-go tasks. Subjects were instructed to inhibit responses to letters, happy faces, or sad faces in separate blocks. Accuracy and reaction time did not differ between groups. Within group results showed activation in regions previously implicated in emotional processing and response inhibition. Between groups results showed increased activation in 9DAT individuals during inhibition. During letter inhibition, 9DAT individuals exhibited greater activation in right inferior parietal regions. During sad inhibition, 9DAT Individuals exhibited greater activation in frontal, posterior cingulate, precuneus, right cerebellar, left paracentral, and right occipital brain regions. The interaction between DAT genotype and response type in sad versus letter stimuli showed increased activation in 9DAT individuals during sad no-go responses in the anterior cingulate cortex, extending into frontal-orbital regions. 9DAT individuals have greater activation than 10DAT individuals during neutral and sad inhibition, showing that genotypic variation influencing basal dopamine levels can alter the neural basis of emotional processing and response inhibition. This may indicate that 9R carriers exert more effort to overcome increased basal dopamine activation when inhibiting responses in emotional contexts
Antiferromagnetic spin Seebeck Effect
We report on the observation of the spin Seebeck effect in antiferromagnetic
MnF. A device scale on-chip heater is deposited on a bilayer of Pt (4
nm)/MnF (110) (30 nm) grown by molecular beam epitaxy on a MgF (110)
substrate. Using Pt as a spin detector layer it is possible to measure
thermally generated spin current from MnF through the inverse spin Hall
effect. The low temperature (2 - 80 K) and high magnetic field (up to 140 kOe)
regime is explored. A clear spin flop transition corresponding to the sudden
rotation of antiferromagnetic spins out of the easy axis is observed in the
spin Seebeck signal when large magnetic fields (>9 T) are applied parallel the
easy axis of the MnF thin film. When magnetic field is applied
perpendicular to the easy axis, the spin flop transition is absent, as
expected
Emotional response inhibition in bipolar disorder: a functional magnetic resonance imaging study of trait- and state-related abnormalities
BACKGROUND:
Impaired response inhibition and poor impulse control are hallmarks of the manic phase of bipolar disorder but are also present during depressive and, to a lesser degree, euthymic periods. The neural mechanisms underlying these impairments are poorly understood, including how mechanisms are related to bipolar trait or state effects.
METHODS:
One-hundred four unmedicated participants with bipolar mania (BM) (n = 30), bipolar depression (BD) (n = 30), bipolar euthymia (BE) (n = 14), and healthy control subjects (n = 30) underwent functional magnetic resonance imaging during emotional and nonemotional go/no-go tasks. The go/no-go task requires participants to press a button for go stimuli, while inhibiting the response to no-go trials. In separate blocks, participants inhibited the response to happy faces, sad faces, or letters.
RESULTS:
The BE group had higher insula activity during happy face inhibition and greater activity in left inferior frontal gyrus during sad face inhibition, demonstrating bipolar trait effects. Relative to the BE group, BD and BM groups demonstrated lower insula activity during inhibition of happy faces, though the depressed sample had lower activity than manic patients. The BD and BM groups had a greater response to inhibiting sad faces in emotion processing and regulation regions, including putamen, insula, and lateral prefrontal cortex. The manic group also had higher activity in insula and putamen during neutral letter inhibition.
CONCLUSIONS:
These results suggest distinct trait- and state-related neural abnormalities during response inhibition in bipolar disorder, with implications for future research and treatment
Neural activation during risky decision-making in youth at high risk for substance use disorders
Risky decision-making, particularly in the context of reward-seeking behavior, is strongly associated with the presence of substance use disorders (SUDs). However, there has been little research on the neural substrates underlying reward-related decision-making in drug-naïve youth who are at elevated risk for SUDs. Participants comprised 23 high-risk (HR) youth with a well-established SUD risk phenotype and 27 low-risk healthy comparison (HC) youth, aged 10-14. Participants completed the balloon analog risk task (BART), a task designed to examine risky decision-making, during functional magnetic resonance imaging. The HR group had faster reaction times, but otherwise showed no behavioral differences from the HC group. HR youth experienced greater activation when processing outcome, as the chances of balloon explosion increased, relative to HC youth, in ventromedial prefrontal cortex (vmPFC). As explosion probability increased, group-by-condition interactions in the ventral striatum/anterior cingulate and the anterior insula showed increasing activation in HR youth, specifically on trials when explosions occurred. Thus, atypical activation increased with increasing risk of negative outcome (i.e., balloon explosion) in a cortico-striatal network in the HR group. These findings identify candidate neurobiological markers of addiction risk in youth at high familial and phenotypic risk for SUDs
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