The Effect of Environmental Enrichment with Autistic-like Behavior Symptoms on a Rattus norvegicus Model

AIM: The aim of this study was to investigate the effect of environmental enrichment with autistic-like behavior symptoms on a Rattus norvegicus model. METHODS: The post-test control only group design is used in this study. The study sample is baby of Rattus norvegicus Sprague Dawley strain who were born to cows who gave birth for the 1st time and children from cows who had been injected with valproic acid (VPA) who gave birth for the 1st time. This study has been divided into three groups, namely, negative control, positive control, and intervention: the negative control group; the VPA without enrichment as positive control; and the VPA group with enrichment as intervention group. One-way ANOVA tests were used to data analysis. Data are processed using SPSS version 23.0. RESULTS: This study showed that the mean of social interaction in the negative control group was 359.11 ± 39.33 s higher than the positive control, namely, 182.00 ± 35.80 s and 244.56 ± 19.06 s for intervention. The mean of repetitive movement in the negative control group was 48.00 ± 9.03 s lower than the positive control, namely, 212.11 ± 41.43 s and intervention 160.00 ± 18.91 s. There has been an influence of environmental enrichment with social interaction and repetitive movements on a Rattus norvegicus model (p < 0.05). CONCLUSION: This study confirmed that there has been an influence of environmental enrichment with social interaction and repetitive movements on a Rattus norvegicus model

Comparison of Immunoreactivity Serum Neuregulin 1 in Bataks Ethnic with Schizophrenia Paranoid and Bataks Ethnic Healthy Control

Protein measurements in blood are often used to investigate the pathological contribution of individual molecules. Neuregulin1 (NRG1) proteins influences the development of white matter connectivity and is implicated in genetic susceptibility in schizophrenia (NRG1  proteins in rat, Frenzel, NRG1 1 genetic variation Fei Wang). Neuregulin 1 affects the regulation of central nervous system myelination by inducing the migration and differentiation of oligodendrocytes in the CNS. The objective of the present study is to make comparison of immunoreactivity serum Neuregulin 1 in Bataks ethnic with schizophrenia and Bataks ethnic healthy control. Serum samples were collected from 42 Bataks ethnic with schizophrenia (21 men, 21 women) and 30 control subjects (15 men, 15 women). Neuregulin 1 was measured by ELISA using antibody against NRG 1 beta 1. The differences between Bataks ethnic with schizophrenia and healthy control were assessed using Mann Whitney test (significant value p < 0,05). Mean immunoreactivity of serum Neuregulin 1 in schizophrenic patients 14,51 pg/ml (SD ± 6,81) and mean immunoreactivity of serum neuregulin 1 in control subjects 13,12 pg/ml (SD ± 2,49). Immunoreactivity of serum neuregulin 1 in Batak ethnics with schizophrenia was significantly higher than in Bataks ethnic healthy control (p=0,036). Keywords: serum neuregulin- schizophrenia- Bataks ethni

Dilatation Treatment for Esophageal Strictures

A patient with adjustment disorder and depression had experienced a suicide temptation by ingesting corrosive substance since 6 months before her hospital admission. On the first day care, she only can swallow “soft-fluid diet” which is given very slowly. Subsequently, the patient had a series of dilatation treatment guided by fluoroscopy and demonstrated a very impressive result. On the first dilatation, a 7 mm dilator was used, and then respectively 9, 10, 5, 12, 8 and 14 mm dilator was applied. We needed to perform three sessions of dilatation until the 9 mm dilator can be inserted. After the second dilatation, the patient had started to be able to eat refine porridge and subsequently rice porridge with soft vegetables and side dishes. At the end of treatment, she had already been able to eat normally. The general management of esophageal stricture by using dilator will be discussed in this article

Rates and Risk Factors for Suicide Ideas among Schizophrenia Patients in Indonesia

BACKGROUND: Schizophrenia is associated with a high rate of suicide. AIM: Our study was aimed to identify the rates of suicide ideas in patients with schizophrenia as well as the risk factors associated with suicide ideas. METHODS: As many as 1130 subjects were evaluated using the Indonesian version of Diagnosis Interview for Psychosis (DIP) to establish the diagnosis of schizophrenia. Subjects aged 18-65 years. The risk factors were socio-demographic data, mental disorder history in the family, clinical symptoms and clinical course of schizophrenia. Risk factors that have the strongest correlation with suicide ideas were analysed using multivariate logistic regression analysis. RESULTS: About 6.1% of subjects reported suicide ideas in their life. The age of disease onset (p = 0.006), family history of schizophrenia (p = 0.013), poor concentration (p = 0.032), loss of enjoyment (p = 0.000), guilty feeling (p = 0.000), family history of mental illness (p = 0.000), nihilistic delusion (p = 0.001) and alcohol abuse (p = 0.000) were significantly associated with suicide ideas. CONCLUSION: Suicide idea is quite common in people with schizophrenia. Evaluation and management of risk factors associated with suicide ideas should be performed to prevent suicide attempts or death. Suicide ideas and risk factors can become clinical parameters in the instrument of suicide prevention

Depresi aspek neurobiologi diagnosis dan tatalaksana

vii.140hal.;15x24c

Marketing Mix: Keputusan Nasabah Memilih Tabungan Simpeda Pada Bank Sulselbar

This study departs from the problem that whether the marketing mix has a simultaneous and partial effect on customer decisions to use the simpeda product. The aim is to find out and analyze how much influence the marketing mix (7P) has on customer decisions in choosing SIMPEDA products at PT. Bank Sulselbar Mamuju Main Branch and the most dominant variable. This research approach is quantitative. The sampling technique is incidental sampling with a total of 100 respondents. The results showed that the product, price, place, promotion, people, physical evidence and process variables simultaneously had a positive and significant effect on customer decisions in choosing SIMPEDA Savings at PT. Bank Sulselbar Mamuju Main Branch. Meanwhile, the T-test results show that the product, price, promotion and process variables partially have a positive and significant effect. While the variables of place, person and physical evidence partially have no effect and are not significant. The dominating variable is promotion has a positive and significant effect in choosing SIMPEDA Savings at PT. Bank Sulselbar Mamuju Main Branch.Penelitian ini berangkat dari permasalahan bahwa apakah marketing mix berpengaruh secara simultan dan parsial terhadap keputusan nasabah menggunakan prosuk simpeda. Tujuannya adalah  mengetahui   dan   menganalisis seberapa besar   pengaruh   bauran   pemasaran   (7P)   terhadap   keputusan nasabah dalam memilih Produk SIMPEDA pada PT. Bank Sulselbar Cabang Utama Mamuju dan variabel yang paling dominan. Pendekatan penelitian ini adalah kuantitaif. Teknik penarikan sampel adalah sampling insidental dengan jumlah 100  responden.  Hasil penelitian menunjukkan secara simultan variabel  produk, harga, tempat, promosi,   orang, bukti fisik dan proses berpengaruh positif dan signifikan  terhadap  keputusan  nasabah dalam memilih Tabungan SIMPEDA pada PT. Bank Sulselbar Cabang Utama Mamuju. Sementara Hasil Uji T menunjukkan bahwa  variabel  produk,  harga,  promosi dan  proses masing-masing  secara  parsial berpengaruh positif dan signifikan. Sementara variabel tempat, orang dan bukti fisik secara parsial tidak berpengaruh dan tidak signifikan. Adapun variabel yang mendominasi yaitu promosi berpengaruh positif dan signifikan dalam memilih Tabungan SIMPEDA pada PT. Bank Sulselbar Cabang Utama Mamuju

Depresi Aspek Neurobiologi Diagnosis dan Tatalaksana

vii, 140 h, 24 c

Hubungan Antara Rerata Kadar Seng dalam Serum dengan Gejala Klinis Gangguan Pemusatan Perhatian dan Hiperaktivitas pada Anak Berdasarkan Skala Penilaian Perilaku Anak Hiperaktif Indonesia

Latar belakang. Gangguan Pemusatan Perhatian dan Hiperaktivitas (GPPH) merupakan salah satu gangguan jiwa yang dijumpai pada anak. Terdapat tiga tipe gejala utama GPPH, yaitu kesulitan memusatkan perhatian, hiperaktivitas, dan impulsivitas. Hingga saat ini, belum dapat disimpulkan penyebab pasti terjadinya GPPH. Namun, hasil berbagai penelitian menunjukkan adanya kaitan dengan nutrisi, yaitu adanya defisiensi seng. Tujuan. Mengetahui perbedaan rerata antara kadar seng dalam serum pada anak dengan GPPH dibandingkan dengan kelompok kontrol anak sehat dan mengetahui hubungan antara rerata kadar seng dalam serum dengan gejala klinis pada anak dengan GPPH. Metode. Desain penelitian pendekatan metode potong lintang dengan kontrol anak sehat. Penelitian dilakukan di SDN 01 Pagi Kampung Melayu, Jakarta Timur, pada bulan Mei – Juni 2013. Jumlah sampel pada masing-masing kelompok yaitu 42. Hasil. Didapatkan nilai tengah kadar seng dalam serum untuk kelompok anak GPPH 52,50 μg/L dan kadar seng dalam serum untuk kelompok anak sehat 51,50 μg/L. Tidak ada perbedaan yang bermakna antara kedua nilai tengah kadar seng dalam serum antara kelompok anak yang menderita GPPH dengan anak sehat. Tidak ada hubungan bermakna antara rerata kadar seng dalam darah dengan gejala klinis GPPH. Kesimpulan. Tidak didapatkan perbedaan rerata kadar seng dalam darah antara kelompok anak GPPH dibandingkan dengan anak sehat, dan tidak didapatkan hubungan kadar seng dalam darah pada anak GPPH dengan gejala klinis GPPH yang dinilai berdasarkan Skala Penilaian Perilaku Anak Hiperaktivitas Indonesia (SPPAHI)

Leksikon istilah kesehatan jiwa dan psikiatri

Buku ini menyajikan langkah utama pencapaian nomenklatur yang diterima secara internasional untuk gangguan jiwa dan dapat diaplikasikan secara luas dalam bidang klinik, pendidikan, dan penelitian.v, 174 hlm.: ilus.; 21 c

Perceived external prestige: Meta-perception of nurses and customers’s opinion in hospital, Makassar City

This study aims to measure the accuracy of nursing meta-perception on the prestige of the hospital based on customers (perceived external prestige). The research was conducted at five locations; Hospitals A, B, C, D and E in Makassar City. The locations of the study were determined by the trend of the turnover rate at those five hospitals in the last three years. The population was nurses with non-permanent status (freelance, honorary, contract, and intern permanent) for all hospitals as many as 214 people. As a control on the assessment of the accuracy of nurses' meta perception, a survey was conducted on customers at each study site. In general, there is a similar perception between nurses and customers, although the nurse's perceived value is higher than customers. This means that nurses have high optimism than the actual customer's perceptions. There was no correlation between nurses’ perceived external prestige with customers' opinions. Therefore, the hospital should always be active and continuous in seeking information needs and desires of the customer in an effort to provide the best service