Characterizing HCI Research in China: Streams, Methodologies and Future Directions

This position paper takes the first step to attempt to present the initial characterization of HCI research in China. We discuss the current streams and methodologies of Chinese HCI research based on two well-known HCI theories: Micro/Marco-HCI and the Three Paradigms of HCI. We evaluate the discussion with a survey of Chinese publications at CHI 2019, which shows HCI research in China has less attention to Macro-HCI topics and the third paradigms of HCI (Phenomenologically situated Interaction). We then propose future HCI research directions such as paying more attention to Macro-HCI topics and third paradigm of HCI, combining research methodologies from multiple HCI paradigms, including emergent users who have less access to technology, and addressing the cultural dimensions in order to provide better technical solutions and support

THE ANALYSIS OF THE EFFECT OF CURRENT RATIO (CR), RETURN ON EQUITY (ROE), DIVIDEND PAYOUT RATIO (DPR), AND DEBT TO EQUITY RATIO (DER) TOWARD PRICE EARNING RATIO (PER) AT MANUFACTURING COMPANIES IN JAKARTA ISLAMIC INDEX (JII) PERIOD 2011 – 2017

Price Earning Ratio adalah sebuah rasio yang seringkali digunakan oleh para investor untuk menilai apakah sebuah perusahaan bisa dijadikan objek investasi yang menghasilkan keuntungan. salah satu manfaat dari Price Earning Ratio adalah untuk mengetahui bagaimana kinerja perusahaan dalam menghasilkan laba. enelitian ini bertujuan untuk menganalisis pengaruh Current Ratio (CR), Return on Equity (ROE), Dividend payout Ratio (DPR), dan Debt to Equity Ratio (DER) pada Perusahaan Manufaktur yang terdaftar di Jakarta Islamic Index (JII) periode 2011 – 2017 baik secara simultan maupun parsial. Populasi dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Jakarta Islamic Index (JII) periode 2011 – 2017. Dengan menggunakan metode purposive sampling, diperoleh sampel dalam penelitian ini sejumlah 10 (sepuluh) Perusahaan Manufaktur. Model analisis dalam penelitian ini menggunakan model analisis regresi liniear data panel. Teknik analisis menggunakan Random Effect Model. Uji koefisien Determinasi (R2), uji hipotesis F-test dan T-test dengan tingkat signifikansi 5%.Hasil penelitin ini menunjukan bahwa Current Ratio (CR), Return on Equity (ROE), Dividend payout Ratio (DPR), dan Debt to Equity Ratio (DER) secara simultan berpengaruh signifikan terhadap Price Earning Ratio (PER) pada Perusahaan Manufaktur yang terdaftar di Jakarta Islamic Index (JII) periode 2011 – 2017. Current Ratio (CR) secara parsial berpengaruh signifikan terhadap Price Earning Ratio (PER), sedangkan Return on Equity (ROE), Dividend payout Ratio (DPR), dan Debt to Equity Ratio (DER) tsecara parsial tidak berpengaruh signifikan terhadap Price Earning Ratio (PER) pada Perusahaan Manufaktur yang terdaftar di Jakarta Islamic Index (JII) periode 2011 – 2017

Self-Tracking by People Living with Multiple Sclerosis: Supporting Experiences of Agency in a Chronic Neurological Condition

Multiple sclerosis is a complex neurological condition. It disrupts the central nervous system leading to an individual range of physical, cognitive, and mental impairments. Research has focused on the tracking of primary disease indicators and disability outcome measures to assess the progression of this condition. However, there is little knowledge on how technologies could support the needs of people with multiple sclerosis (MS) in self-tracking their health and wellbeing. Drawing on qualitative research and design methods this thesis provides two contributions. Firstly, it improves understanding of self-tracking in MS self-management. Interview participants reported regaining a sense of control over MS through intertwining individual self-care practices with different self-tracking tools, including paper notebooks and fitness wearables. They associated experiences of control with their agency to document their health in holistic ways, involving symptom monitoring and life journaling. However, participants criticised that self-tracking apps can impede their capacities, in particular when the user experience is focused on predefined health indicators and the optimisation of health behaviour. These findings highlight the need to support people’s individual self-care intentions and agentive capacities through customisable self- tracking approaches. Secondly, this thesis contributes the design of Trackly, a technology probe that supports people in defining and colouring pictorial trackers, such as body shapes. We identify benefits and challenges of customisable and pictorial self-tracking through a field study of Trackly in MS self-management. Having been able to support their individual self-care intentions with Trackly, participants reported a spectrum of interrelated experiences of agency, including ownership, identity, awareness, mindfulness, and control. Overall, this thesis provides a qualitative account and design perspective that demonstrate how adapting self-tracking technologies to individual care needs supported experiences of agency. These findings are particularly relevant to the design of technologies aimed at leveraging personally meaningful self-care and quality of life

Expression and Characterization of Mouse Notch1 \u3ci\u3eAbruptex\u3c/i\u3e EGF Repeats in \u3ci\u3eE. coli\u3c/i\u3e

Notch1 is a transmembrane protein involved in cell signaling, which is found to be linked to various genetic and neurodegenerative diseases. The extracellular domain of the Notch1 protein consists of 36 tandem epidermal growth factor-like (EGF) repeats, which are directly involved in ligand binding and are heavily glycosylated. EGF 24-29 repeats lie in the Abruptex region of the Notch1 protein, and regulate the ligand binding activity through structural changes. The role of glycosylation in ligand binding events and the overall structure of the Abruptex region are not known. Also, the role of calcium binding in Notch activation or inhibition is not clear. The goal of this project is to use NMR spectroscopy to study the structure of EGF domains with and without glycosylation, and a three dimensional structure of the Abruptex EGF repeats will be determined. The structures will provide a model to the Abruptex region of Notch1 and will further aid in our understanding of ligand binding activity in the extracellular domain of the Notch1

Detection of QTL affecting flesh quality traits (body lipid percentage and flesh colour) using molecular markers (microsatellites and AFLP markers) in Atlantic salmon (Salmo salar L.)

Flesh colour and fillet fat percentage are the two most important attributes to salmon fillet quality. A medium genetic component to body lipid percentage within commercial lines has previously been shown (h2 = 0.17-0.24). A low level of heritability (h2 = 0.16) has also been reported for flesh colour in Atlantic salmon. To investigate whether this genetic component includes loci of major effect, a genome-wide QTL scan was performed with commercially bred Atlantic salmon (Landcatch Natural Selection). Five large full-sib families (10 parents with 153 offspring) were genotyped using microsatellite markers. To utilize the large difference between sire and dam recombination rate, a two-stage genotyping was employed. Initially, the parents and offspring were genotyped for two microsatellite markers per linkage group, and sire based QTL analysis was used to detect linkage groups with significant effects on those flesh quality traits. A linear-regression based interval as analytical method was applied for QTL detection. The results revealed evidence of QTLs affecting percentage fat percentage and flesh colour on linkage groups LNS16 and LNS1 respectively. To confirm the QTL and to provide an improved estimate of position, a dam-based analysis was then employed. One major QTL was located on the genome-wide significance level for percentage fat percentage. Microsatellite marker Ssa0016NVH (at position of 1.3 cM) was found to be tightly linked to QTL affecting percentage fat percentage. In addition, a QTL affecting flesh colour was found to be flanked by microsatellite markers Ssa9.44NUIG at position of 68.7 cM and Ssa0021NVH at position of 50.6 on linkage group LNS16. The evidence for suggestive QTL affecting flesh colour on linkage group LNS1 was also revealed. In order to increase marker density within these and other linkage groups, AFLP markers were employed, 24 primer combinations resulted in a total of 489 polymorphic fragments. Among 11 fragments that were found to be linked to the microsatellite markers on linkage group LNS16, four fragments (AAG-CAC328, AGG-CAG447, AGG-CTA237 and AGG-CTC237) were tightly linked to microsatellite marker Ssa9.44NUIG, but none were found to be linked to microsatellite Ssa0021NVH. Moreover, none of the AFLP markers were found to be linked to microsatellites residing on linkage group LNS1. Using a constructed map of microsatellite and AFLP markers for linkage group LNS16, the dam based analysis revealed a significant QTL for flesh colour at the location of 189 cM, while the sire based analysis detected a significant QTL for fat percentage at the location of 80 cM. Considering the dominant nature and clustering character of AFLP markers, it was concluded that a certain primer combination in AFLP markers could be of limited use for fine mapping and QTL detection in Atlantic salmon

The Death of the Autonomous Venezuelan Judiciary

Access to impartial and effective courts is the cornerstone of democratic civil society. When the intention of political actors is to extinguish democratic civil society, they often wear away at the autonomy of the judiciary. International law and the constitutions of many states throughout the world guarantee access to autonomous courts. Despite having such guarantees in place, the government of the Bolivarian Republic of Venezuela has consistently attacked the judiciary in order to erode its autonomy and bring it under political control. Strategies used to achieve that goal include purging judges, intimidating them, and preventing judges from getting tenure. As a result, today there are two parallel Venezuelan judiciaries competing for authority while citing to the same constitution. This article will present evidence regarding the methods through which the autonomy of Venezuela’s courts was intentionally destroyed by the Chavista government. It will begin by looking at the history of the judicial power created by the constitution of 1999, analyze the specific acts that led to the politicization of the courts, and explore the effects of that politicization on Venezuelan constitutional government