46 research outputs found
From Academia to the Market â Air-stable Ni(II)/Josiphos Catalysts
The design, synthesis, commercialization and application of air stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes  are utilized as versatile precatalysts for diverse cross coupling reactions. Apart from being active in established CâC and CâN couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the alpha-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts
Nouvelle approche duale métallique-organique pour la catalyse de polymérisation d'esters cycliques (du concept de coopérativité vers la synthÚse de polyesters à architectures originales)
TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF
Ring-Opening Polymerization with Zn(C6F5)2-Based Lewis Pairs: Original and Efficient Approach to Cyclic Polyesters
International audienceDual systems combining Zn(C6F5)2 with an organic base (an amine or a phosphine) promote the controlled ring-opening polymerization of lactide and Δ-caprolactone. The Lewis pairs cooperate to activate the monomers, affording well-defined high molecular weight cyclic polyesters. Efficient chain-extension gives access to cyclic block copolymers
Synthesis, structure and reactivity of an NHC silyl gold(I) complex
International audienceThe first example of a silyl gold(I) complex stabilized by an N-heterocyclic carbene (NHC) was synthesised and fully characterized, including crystallographically. The syn insertion of methyl propiolate into the Au-Si bond leading to a vinyl gold complex is reported. As substantiated by X-ray diffraction analysis, the reaction proceeds with opposite regioselectivity compared to that observed previously with phosphine silyl gold(I) complexes
Silyl Radical Mediated Cross-Electrophile Coupling of N -Acyl-imides with Alkyl Bromides under Photoredox/Nickel Dual Catalysis
International audienceA photoredox Ni-catalyzed cross-coupling of N-acyl-imides with unactivated alkyl bromides has been developed that enables efficient access to a variety of functionalized alkyl ketones, including unsymmetrical dialkyl ketones, under very mild and operationally practical conditions. The reaction that operates without the need for any preformed carbon nucleophile proceeds via the combination of two different bond activation processes, i.e. Ni-catalyzed imide activation via C(acyl)âN bond cleavage and (TMS)3Si radical-mediated alkyl halide activation via halogen-atom abstraction
Gold(I)/Gold(III) Catalysis that Merges Oxidative Addition and ÏâAlkene Activation
International audienceThe hetero-arylation of alkenes with aryl iodides has been efficiently achieved with the (MeDalphos)AuCl complex via Au(I)/Au(III) catalysis. The possibility to combine oxidative addition of aryl iodides and Ï-activation of alkenes at gold is demonstrated for the first time. The reaction is robust and general (>30 examples including internal alkenes, 5, 6 and 7-membered rings). It is regioselective and leads exclusively to trans addition products. The (P,N) gold complex is most efficient with electron-rich aryl substrates, which are troublesome with alternative photoredox / oxidative approaches. In addition, it actuates a very unusual switch in regioselectivity from 5-exo to 6-endo cyclization between the Z and E isomers of internal alkenols
pi Complexes of P^P and P^N Chelated Gold(I)
International audienceTricoordinate gold(I) pi-complexes featuring P-based chelating ligands (P^P and P^N) were prepared. The structure of the gold(I) styrene complexes have been analysed in detail based on NMR and XRD data. The P^N complex is a competent catalyst for indole alkylation. The reaction proceeds with complete C3 and Markovnikov selectivity
C(sp3)âH Bond Acylation with N-Acyl Imides under Photoredox/ Nickel Dual Catalysis
International audienceA novel Ni/photoredox-catalyzed acylation of aliphatic substrates, including simple alkanes and dialkyl ethers, has been developed. The method combines CâN bond activation of amides with a radical relay mechanism involving hydrogen-atom transfer. The protocol is operationally simple, employs bench-stable N-acyl imides as acyl-transfer reagents, and permits facile access to alkyl ketones under very mild conditions