Data report : stress measurements in the bottom boundary layer with BASS tripods STRESS II 1990-91

Two Benthic Acoustic Strss Sensor (BASS) equipped tripods were deployed in the Sediment TRansport Events on Shelves and Slopes (STRESS) experiment on the Californa Shelf acquiring data from January to March 1991. They measured velocity profiles in the bottom boundary layer over the lowest 5 meters. Trasmissometers, thermistors, and a pressure sensor on each tripod provided suspended sediment concentration, stratification, and wave spectral information, as well.Funding was provided by the Office of Naval Research under Grant Nos. N00014-89-J-1058 and N00014-90-J-1046

Cardiorespiratory fitness estimation using wearable sensors: laboratory and free-living analysis of context-specific submaximal heart rates

In this work, we propose to use pattern recognition methods to determine submaximal heart rate (HR) during specific contexts, such as walking at a certain speed, using wearable sensors in free-living, and use context-specific HR to estimate cardiorespiratory fitness (CRF). CRF of 51 participants was assessed by a maximal exertion test (VO2max). Participants wore a combined accelerometer and HR monitor during a laboratory based simulation of activities of daily living and for two weeks in free-living. Anthropometrics, HR while lying down and walking at predefined speeds in laboratory settings were used to estimate CRF. Explained variance (R2) was 0.64 for anthropometrics, and increased up to 0.74 for context-specific HR (0.73 to 0.78 when including fat-free mass). Then, we developed activity recognition and walking speed estimation algorithms to determine the same contexts (i.e. lying down and walking) in free-living. Context-specific HR in free-living was highly correlated with laboratory measurements (Pearson's r = 0.71-0.75). R2 for CRF estimation was 0.65 when anthropometrics were used as predictors, and increased up to 0.77 when including free-living context-specific HR (i.e. HR while walking at 5.5 km/h). R2 varied between 0.73 and 0.80 when including fat-free mass among the predictors. RMSE was reduced from 354.7 ml/min to 281.0 ml/min by the inclusion of context-specific HR parameters (21% error reduction). We conclude that pattern recognition techniques can be used to contextualize HR in free-living and estimated CRF with accuracy comparable to what can be obtained with laboratory measurements of HR response to walking

Influences of physical oceanographic processes on chlorophyll distributions in coastal and estuarine waters of the South Atlantic Bight

Coastal and estuarine waters of the South Atlantic Bight are highly productive, with primary production of 600-700 gC/m2/y. While controls and fate of this production are conceptually well understood, the importance of meteorology and physical circulation processes on phytoplankton has not received equivalent attention. Here, we describe the effects of wind stress and tidal currents on temporal and spatial distributions of phytoplankton biomass represented as chlorophyll a (chl a). Moored instruments were deployed and shipboard sampling was conducted in the North Edisto estuary (South Carolina) and adjacent inner shelf waters during four, two-week field studies in May and August 1993, and June and September 1994. Local wind regimes induced upwelling- and downwelling-favorable conditions which strengthened or reduced vertical density stratification in the coastal frontal zone, respectively, and shifted the location of the front. Chl a in shelf waters was more or less homogenous independent of the wind regime, while chl a on the estuary delta was generally vertically stratified. Within the estuary, chl a concentrations were positively correlated with the alongshore component of wind stress; chl a was not correlated with the weaker cross-shelf component of wind stress. Highest chl a occurred during strong downwelling-favorable events. The quick response time to wind forcing (6-12 hrs) implied a direct effect on chl a distributions and not a stimulation of growth processes. The source of the elevated chl a in response to wind forcing was apparently resuspension of settled and epibenthic algal cells. Tidal currents also influenced the vertical distribution and concentration of chl a. Time series sampling on the estuary delta showed that, with increasing velocity of ebb and flood tide currents, the relative contributions of pennate and centric diatoms with attached detritus and sand grains also increased, indicating that tidal resuspension of settled and epibenthic microalgae also occurred. Vertical stratification of chl a (highest concentrations near the bottom) began to degrade upon mixing by tidal currents with velocities as low as 10 cm/sec. Homogenization of 5-7 m water columns was fully achieved at velocities of 20-30 cm/sec. The data document the direct and comparatively immediate (timescales of minuteshours) impact of tidal and wind energy on concentrations and distribution patterns of phytoplankton in coastal and estuarine waters of the South Atlantic Bight

Early indication of decompensated heart failure in patients on home-telemonitoring: a comparison of prediction algorithms based on daily weight and noninvasive transthoracic bio-impedance.

Heart Failure (HF) is a common reason for hospitalization. Admissions might be prevented by early detection of and intervention for decompensation. Conventionally, changes in weight, a possible measure of fluid accumulation, have been used to detect deterioration. Transthoracic impedance may be a more sensitive and accurate measure of fluid accumulation.In this study, we review previously proposed predictive algorithms using body weight and noninvasive transthoracic bio-impedance (NITTI) to predict HF decompensations.We monitored 91 patients with chronic HF for an average of 10 months using a weight scale and a wearable bio-impedance vest. Three algorithms were tested using either simple rule-of-thumb differences (RoT), moving averages (MACD), or cumulative sums (CUSUM).Algorithms using NITTI in the 2 weeks preceding decompensation predicted events (P<.001); however, using weight alone did not. Cross-validation showed that NITTI improved sensitivity of all algorithms tested and that trend algorithms provided the best performance for either measurement (Weight-MACD: 33%, NITTI-CUSUM: 60%) in contrast to the simpler rules-of-thumb (Weight-RoT: 20%, NITTI-RoT: 33%) as proposed in HF guidelines.NITTI measurements decrease before decompensations, and combined with trend algorithms, improve the detection of HF decompensation over current guideline rules; however, many alerts are not associated with clinically overt decompensation

Feasibility and cost description of highly intensive rehabilitation involving new technologies in patients with post-acute stroke-a trial of the Swiss RehabTech Initiative

BACKGROUND There is a need to provide highly repetitive and intensive therapy programs for patients after stroke to improve sensorimotor impairment. The employment of technology-assisted training may facilitate access to individualized rehabilitation of high intensity. The purpose of this study was to evaluate the safety and acceptance of a high-intensity technology-assisted training for patients after stroke in the subacute or chronic phase and to establish its feasibility for a subsequent randomized controlled trial. METHODS A longitudinal, multi-center, single-group study was conducted in four rehabilitation clinics. Patients participated in a high-intensity 4-week technology-assisted trainings consisting of 3 to 5 training days per week and at least 5 training sessions per day with a duration of 45 min each. Feasibility was evaluated by examining recruitment, intervention-related outcomes (adherence, subjectively perceived effort and effectiveness, adverse events), patient-related outcomes, and efficiency gains. Secondary outcomes focused on all three domains of the International Classification of Functioning Disability and Health. Data were analyzed and presented in a descriptive manner. RESULTS In total, 14 patients after stroke were included. Participants exercised between 12 and 21 days and received between 28 and 82 (mean 46 ± 15) technology-assisted trainings during the study period, which corresponded to 2 to 7 daily interventions. Treatment was safe. No serious adverse events were reported. Minor adverse events were related to tiredness and exertion. From baseline to the end of the intervention, patients improved in several functional performance assessments of the upper and lower extremities. The efficiency gains of the trainings amounted to 10% to 58%, in particular for training of the whole body and for walking training in severely impaired patients. CONCLUSIONS Highly intensive technology-assisted training appears to be feasible for in- and outpatients in the subacute or chronic phase after stroke. Further clinical trials are warranted in order to define the most comprehensive approach to highly intensive technology-assisted training and to investigate its efficacy in patients with neurological disorders. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT03641651 at August 31st 2018

Impact of co-adsorbed oxygen on crotonaldehyde adsorption over gold nanoclusters : a computational study

Crotonaldehyde (2-butenal) adsorption over gold sub-nanometer particles, and the influence of co-adsorbed oxygen, has been systematically investigated by computational methods. Using density functional theory, the adsorption energetics of crotonaldehyde on bare and oxidised gold clusters (Au13, d = 0.8 nm) were determined as a function of oxygen coverage and coordination geometry. At low oxygen coverage, sites are available for which crotonaldehyde adsorption is enhanced relative to bare Au clusters by 10 kJ mol−1. At higher oxygen coverage, crotonaldehyde is forced to adsorb in close proximity to oxygen weakening adsorption by up to 60 kJ mol−1 relative to bare Au. Bonding geometries, density of states plots and Bader analysis, are used to elucidate crotonaldehyde bonding to gold nanoparticles in terms of partial electron transfer from Au to crotonaldehyde, and note that donation to gold from crotonaldehyde also becomes significant following metal oxidation. At high oxygen coverage we find that all molecular adsorption sites have a neighbouring, destabilising, oxygen adatom so that despite enhanced donation, crotonaldehyde adsorption is always weakened by steric interactions. For a larger cluster (Au38, d = 1.1 nm) crotonaldehyde adsorption is destabilized in this way even at a low oxygen coverage. These findings provide a quantitative framework to underpin the experimentally observed influence of oxygen on the selective oxidation of crotyl alcohol to crotonaldehyde over gold and gold–palladium alloys

Impact of co-adsorbed oxygen on crotonaldehyde adsorption over gold nanoclusters : a computational study

Crotonaldehyde (2-butenal) adsorption over gold sub-nanometer particles, and the influence of co-adsorbed oxygen, has been systematically investigated by computational methods. Using density functional theory, the adsorption energetics of crotonaldehyde on bare and oxidised gold clusters (Au13, d = 0.8 nm) were determined as a function of oxygen coverage and coordination geometry. At low oxygen coverage, sites are available for which crotonaldehyde adsorption is enhanced relative to bare Au clusters by 10 kJ mol−1. At higher oxygen coverage, crotonaldehyde is forced to adsorb in close proximity to oxygen weakening adsorption by up to 60 kJ mol−1 relative to bare Au. Bonding geometries, density of states plots and Bader analysis, are used to elucidate crotonaldehyde bonding to gold nanoparticles in terms of partial electron transfer from Au to crotonaldehyde, and note that donation to gold from crotonaldehyde also becomes significant following metal oxidation. At high oxygen coverage we find that all molecular adsorption sites have a neighbouring, destabilising, oxygen adatom so that despite enhanced donation, crotonaldehyde adsorption is always weakened by steric interactions. For a larger cluster (Au38, d = 1.1 nm) crotonaldehyde adsorption is destabilized in this way even at a low oxygen coverage. These findings provide a quantitative framework to underpin the experimentally observed influence of oxygen on the selective oxidation of crotyl alcohol to crotonaldehyde over gold and gold–palladium alloys

Cerebral Small Vessel Disease burden is increased in Systemic Lupus Erythematosus

BACKGROUND AND PURPOSE—: Systemic lupus erythematosus (SLE) increases stroke risk, but the mechanism is uncertain. This study aimed to determine the association between SLE and features on neuroimaging of cerebral small vessel disease (SVD), a risk factor for stroke. METHODS—: Consecutive patients attending a clinic for SLE were recruited. All patients underwent brain magnetic resonance imaging; had blood samples taken for markers of inflammation, endothelial dysfunction, cholesterol, and autoantibodies; and underwent cognitive and psychiatric testing. The data were compared with sex- and age-matched healthy controls and patients with minor stroke. Features of SVD were measured, a total SVD score calculated, and associations sought with vascular risk factors, cognition, SLE activity, and disease duration. RESULTS—: Fifty-one SLE patients (age: 48.8 years; SD: 14.3 years) had a greater total SVD score compared with healthy controls (1 versus 0; P<0.0001) and stroke patients (1 versus 0; P=0.02). There were higher perivascular spaces and deep white matter hyperintensity scores and more superficial brain atrophy in SLE patients versus healthy controls. Despite fewer vascular risk factors than similarly aged stroke patients, SLE patients had similar or more of some SVD features. The total SVD score was not associated with SLE activity, cognition, disease duration, or any blood measure. CONCLUSIONS—: In this data set, SLE patients had a high burden of SVD features on magnetic resonance imaging, particularly perivascular spaces. A larger longitudinal study is warranted to determine the causes of SVD features in SLE and clinical implications