Skeletal health among African Americans with recent-onset rheumatoid arthritis

BACKGROUND: African Americans with rheumatoid arthritis (RA) may be at increased fracture risk. We applied the World Health Organization (WHO) fracture risk assessment tool (FRAX) and National Osteoporosis Foundation (NOF) guidelines to a cohort of African Americans with early RA to identify which patients were recommended for osteoporosis treatment. METHODS: Risk factors and bone mineral density (BMD) were assessed in acohort of African Americans with RA. The WHO FRAX tool estimated ten-year fracture risk. Patients were risk-stratified using FRAX without BMD to identify which individuals might be most efficiently targeted for BMD testing. RESULTS: Participants (n = 324) had a mean age of 51 years and included 81% women. There were no associations of RA disease characteristics with BMD. The proportion of patients recommended for osteoporosis treatment varied from 3% to 86%, depending on age and BMI. Ten-year fracture risk calculated with BMI only was generally the same or higher than fracture risk calculated with BMD; adding BMD data provided the most incremental value to risk assessment in patients 55–70 years of age with low/normal BMI and in those ≥ 70 years of age with BMI > 30 kg/m(2). CONCLUSIONS: A high proportion of African Americans with RA were recommended for treatment under 2008 NOF guidelines. FRAX without BMD identified low risk patients accurately. Systematic application of FRAX to screen high risk groups such as RA patients may be used to target individuals for BMD testing and reduce the use of unnecessary tests and treatments