Utilization of treated water for building construction: A case study in Egypt

Due to rising living standards and population growth, saving fresh water will be a significant problem for the next generation. The Government is indirectly impacted by a significant financial burden due to the current usage of treated wastewater, in all of Egypt's districts. As a case study, Egypt's new administrative capital was chosen, given that it is today one of the most important cities and that its planning was predicated on making it a smart, sustainable city. The goal of the study was to develop methods for replacing potable water in the manufacture of concrete with tertiary-treated wastewater; however, used for concrete mixing or curing after concrete hardening. Property assessments of the fresh and hardened concrete were conducted, to ascertain the best water quality that can be used without compromising the quality or durability of the concrete. ; The results of this paper will serve as a guide for decision-makers looking to decrease costs and increase sustainability by using treated wastewater in making sustainable concrete for buildings, especially in recent decades, rising construction material usage has generated considerable environmental difficulties, particularly in the production of Ordinary Portland cement (OPC)

Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.

Pediatric-onset ataxias often present clinically as developmental delay and intellectual disability, with prominent cerebellar atrophy as a key neuroradiographic finding. Here we describe a new clinically distinguishable recessive syndrome in 12 families with cerebellar atrophy together with ataxia, coarsened facial features and intellectual disability, due to truncating mutations in the sorting nexin gene SNX14, encoding a ubiquitously expressed modular PX domain-containing sorting factor. We found SNX14 localized to lysosomes and associated with phosphatidylinositol (3,5)-bisphosphate, a key component of late endosomes/lysosomes. Patient-derived cells showed engorged lysosomes and a slower autophagosome clearance rate upon autophagy induction by starvation. Zebrafish morphants for snx14 showed dramatic loss of cerebellar parenchyma, accumulation of autophagosomes and activation of apoptosis. Our results characterize a unique ataxia syndrome due to biallelic SNX14 mutations leading to lysosome-autophagosome dysfunction

Biallelic Mutations in Snx14 Cause A Syndromic Form of Cerebellar Atrophy and Lysosome-Autophagosome Dysfunction

Pediatric-onset ataxias often present clinically with developmental delay and intellectual disability, with prominent cerebellar atrophy as a key neuroradiographic finding. Here we describe a novel clinically distinguishable recessive syndrome in 12 families with cerebellar atrophy together with ataxia, coarsened facial features and intellectual disability, due to truncating mutations in sorting nexin 14 (SNX14), encoding a ubiquitously expressed modular PX-domain-containing sorting factor. We found SNX14 localized to lysosomes, and associated with phosphatidyl-inositol (3,5)P2, a key component of late endosomes/lysosomes. Patient cells showed engorged lysosomes and slower autophagosome clearance rate upon starvation induction. Zebrafish morphants showed dramatic loss of cerebellar parenchyma, accumulated autophagosomes, and activation of apoptosis. Our results suggest a unique ataxia syndrome due to biallelic SNX14 mutations, leading to lysosome-autophagosome dysfunction.PubMedWo