44 research outputs found
Intensive family exposure-based cognitive-behavioral treatment for adolescents with anorexia nervosa
Anorexia nervosa exhibits high comorbidity rates and
shared features with anxiety disorders and obsessive-compulsive disorder.
Anxiety-based etiological models have proposed that fear of eating-related
stimuli is the central mechanism around which avoidance of food and foodrelated
rituals are performed. Building on this approach, exposure-based
interventions have demonstrated promising results. Limited evidence in
adolescents encourages the evaluation of exposure approaches in this
population. Method: The current study presents a preliminary evaluation,
in eight adolescents with anorexia nervosa, of an exposure-based CBT
featuring an intensive format and parental involvement. Results:
signifi cant improvements in physical and psychological outcomes were
observed. Conclusions: this case series provides preliminary support
for the effi cacy of intensive family exposure-based CBT for treating
adolescents with severe anorexia nervosa.PsicologĂ
Clinical and Molecular Aspects of Senataxin Mutations in Amyotrophic Lateral Sclerosis 4
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154673/1/ana25681_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154673/2/ana25681.pd
A Substellar Companion to Pleiades HII 3441
We find a new substellar companion to the Pleiades member star, Pleiades HII
3441, using the Subaru telescope with adaptive optics. The discovery is made as
part of the high-contrast imaging survey to search for planetary-mass and
substellar companions in the Pleiades and young moving groups. The companion
has a projected separation of 0".49 +/- 0".02 (66 +/- 2 AU) and a mass of 68
+/- 5 M_J based on three observations in the J-, H-, and K_S-band. The spectral
type is estimated to be M7 (~2700 K), and thus no methane absorption is
detected in the H band. Our Pleiades observations result in the detection of
two substellar companions including one previously reported among 20 observed
Pleiades stars, and indicate that the fraction of substellar companions in the
Pleiades is about 10.0 +26.1/-8.8 %. This is consistent with multiplicity
studies of both the Pleiades stars and other open clusters.Comment: Main text (14 pages, 4 figures, 4 tables), and Supplementary data (8
pages, 3 tables). Accepted for Publications of Astronomical Society of Japa
Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinsonâs Disease patients
IntroductionEvidence suggests that spontaneous beta band (11â35 Hz) oscillations in the basal ganglia thalamocortical (BGTC) circuit are linked to Parkinsonâs disease (PD) pathophysiology. Previous studies on neural responses in the motor cortex evoked by electrical stimulation in the subthalamic nucleus have suggested that circuit resonance may underlie the generation of spontaneous and stimulation-evoked beta oscillations in PD. Whether these stimulation-evoked, resonant oscillations are present across PD patients in the internal segment of the globus pallidus (GPi), a primary output nucleus in the BGTC circuit, is yet to be determined.MethodsWe characterized spontaneous and stimulation-evoked local field potentials (LFPs) in the GPi of four PD patients (five hemispheres) using deep brain stimulation (DBS) leads externalized after DBS implantation surgery.ResultsOur analyses show that low-frequency (2â4 Hz) stimulation in the GPi evoked long-latency (>50 ms) beta-band neural responses in the GPi in 4/5 hemispheres. We demonstrated that neural sources generating both stimulation-evoked and spontaneous beta oscillations were correlated in their frequency content and spatial localization.DiscussionOur results support the hypothesis that the same neuronal population and resonance phenomenon in the BGTC circuit generates both spontaneous and evoked pallidal beta oscillations. These data also support the development of closed-loop control systems that modulate the GPi spontaneous oscillations across PD patients using beta band stimulation-evoked responses
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Recommended from our members
Portable Simulation of Realistic Rain and Wind Environments for Demonstration of Weatherproof Fabrics
The Gore Portable Weather Simulation Chamber is designed to produce variable weather conditions ranging from light drizzle to wind-driven rain. Participants will experience the "Guaranteed to Keep You DryÂź" promise of GORE-TEXÂź fabrics at trade shows, conferences, and recruiting events. The system will accommodate a single participant at a time wearing provided outerwear garments. An audience may observe the participant inside the chamber through clear plastic walls. Readouts will display the current wind and rain conditions within the chamber to the audience. Parallel mechanical and electrical systems have been designed and implemented to ensure participant safety and to suit operator preferences. The system will maintain its own water supply, be powered by a single 120V circuit, allow at least 30% duty cycle, and be able to be assembled or disassembled by two trained associates in 30 minutes or less