High energy cosmic ray self-confinement close to extragalactic sources

The ultra-high energy cosmic rays observed at the Earth are most likely accelerated in extra-galactic sources. For the typical luminosities invoked for such sources, the electric current associated to the flux of cosmic rays that leave them is large. The associated plasma instabilities create magnetic fluctuations that can efficiently scatter particles. We argue that this phenomenon forces cosmic rays to be self-confined in the source proximity for energies $E<E_{\rm cut}$, where $E_{\rm cut}\approx 10^{7} L_{44}^{2/3}$ GeV for low background magnetic fields ($B_{0}\ll nG$). For larger values of $B_{0}$, cosmic rays are confined close to their sources for energies $E<E_{\rm cut}\approx 2\times 10^{8} \lambda_{10} L_{44}^{1/4} B_{-10}^{1/2}$ GeV, where $B_{-10}$ is the field in units of $0.1$ nG, $\lambda_{10}$ is its coherence lengths in units of 10 Mpc and $L_{44}$ is the source luminosity in units of $10^{44}$ erg/s.Comment: To Appear in Physical Review Letter

Contribution to diffuse gamma-ray emission coming from self-confined CRs around their Galactic sources

Recent observations of the diffuse Galactic gamma-ray emission by the Fermi-LAT satellite have shown significant deviations from models which assume the same diffusion properties for cosmic rays (CR) throughout the Galaxy. We explore the possibility that a fraction of this diffuse Galactic emission could be due to hadronic interactions of CRs self-confined in the region around their sources. In fact, freshly accelerated CRs that diffuse away from the acceleration region can trigger the streaming instability able to amplify magnetic disturbance and to reduce the particle diffusion. When this happen, CRs are trapped in the near source region for a time longer than expected and an extended gamma-ray halo is produces around each source. Here we calculate the contribution to the diffuse gamma-ray background due to the overlap along lines of sight of several of these extended halos. We find that if the density of neutrals is low, the halos can account for a substantial fraction of the diffuse emission observed by Fermi-LAT, depending on the orientation of the line of sight with respect to the direction of the galactic center.Comment: 8 pages, 2 figs. Proceeding the 35th International Cosmic Ray Conference (ICRC2017), Bexco, Busan, Kore

Dynamical effects of self-generated magnetic fields in cosmic ray modified shocks

Recent observations of greatly amplified magnetic fields ($\delta B/B\sim 100$) around supernova shocks are consistent with the predictions of the non-linear theory of particle acceleration (NLT), if the field is generated upstream of the shock by cosmic ray induced streaming instability. The high acceleration efficiencies and large shock modifications predicted by NLT need however to be mitigated to confront observations, and this is usually assumed to be accomplished by some form of turbulent heating. We show here that magnetic fields with the strength inferred from observations have an important dynamical role on the shock, and imply a shock modification substantially reduced with respect to the naive unmagnetized case. The effect appears as soon as the pressure in the turbulent magnetic field becomes comparable with the pressure of the thermal gas. The relative importance of this unavoidable effect and of the poorly known turbulent heating is assessed. More specifically we conclude that even in the cases in which turbulent heating may be of some importance, the dynamical reaction of the field cannot be neglected, as instead is usually done in most current calculations.Comment: 4 pages, 1 figure, accepted for publication in ApJ Letter

The tumour microenvironment links complement system dysregulation and hypoxic signalling.

The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated processes such as increased proliferation, angiogenesis and migration. Several cellular members of the tumour microenvironment express and/or produce complement proteins locally, including tumour cells. Dysregulation of the complement system has been reported in numerous tumours and increased expression of complement activation fragments in cancer patient specimens correlates with poor patient prognosis. Importantly, genetic or pharmacological targeting of complement has been shown to reduce tumour growth in several cancer preclinical models, suggesting that complement could be an attractive therapeutic target. Hypoxia (low oxygen) is frequently found in solid tumours and has a profound biological impact on cellular and non-cellular components of the tumour microenvironment. In this review, we focus on hypoxia since this is a prevailing feature of the tumour microenvironment that, like increased complement, is typically associated with poor prognosis. Furthermore, interesting links between hypoxia and complement have been recently proposed but never collectively reviewed. Here, we explore how hypoxia alters regulation of complement proteins in different cellular components of the tumour microenvironment, as well as the downstream biological consequences of this regulation

Evolution of two-gap behavior of the superconductor FeSe_1-x

The superfluid density, \rho_s, of the iron chalcogenide superconductor, FeSe_1-x, was studied as a function of pressure by means of muon-spin rotation. The zero-temperature value of \rho_s increases with increasing transition temperature T_c (increasing pressure) following the tendency observed for various Fe-based and cuprate superconductors. The analysis of \rho_s(T) within the two-gap scheme reveals that the effect on both, T_c and \rho_s(0), is entirely determined by the band(s) where the large superconducting gap develops, while the band(s) with the small gap become practically unaffected.Comment: 5 pages, 3 figure

Precursor Plerionic Activity and High Energy Gamma-Ray Emission in the Supranova Model of Gamma-Ray Bursts

The supranova model of gamma-ray bursts (GRBs), in which the GRB event is preceded by a supernova (SN) explosion by a few months to years, has recently gained support from Fe line detections in X-ray afterglows. A crucial ingredient of this model yet to be studied is the fast-rotating pulsar that should be active during the time interval between the SN and the GRB, driving a powerful wind and a luminous plerionic nebula. We discuss some observational consequences of this precursor plerion, which should provide important tests for the supranova model: 1) the fragmentation of the outlying SN ejecta material by the plerion and its implications for Fe line emission; and 2) the effect of inverse Compton cooling and emission in the GRB external shock due to the plerion radiation field. The plerion-induced inverse Compton emission can dominate in the GeV-TeV energy range during the afterglow, being detectable by GLAST from redshifts $z \lesssim 1.5$ and distinguishable from self-Compton emission by its spectrum and light curve. The prospects for direct detection and identification of the precursor plerion emission are also briefly considered.Comment: ApJ vol.583, in pres

Superconducting and magnetic properties of Sr3Ir4Sn13

Magnetization and muon spin relaxation or rotation (muSR) measurements have been performed to study the superconducting and magnetic properties of Sr3Ir4Sn13. From magnetization measurements the lower and upper critical fields of Sr3Ir4Sn13 are found to be 81(1) Oe and 14.4(2) kOe, respectively. Zero-field muSR data show no sign of any magnetic ordering or weak magnetism in Sr3Ir4Sn13. Transverse-field muSR measurements in the vortex state provided the temperature dependence of the magnetic penetration depth. The dependence of penetration depth with temperature is consistent with the existence of single s-wave energy gap in the superconducting state of Sr3Ir4Sn13 with a gap value of 0.82(2) meV at absolute zero temperature. The magnetic penetration depth at zero temperature is 291(3) nm. The gap to Tc ratio is 2.1(1), indicates that Sr3Ir4Sn13 should be considered as a strong-coupling superconductor.Comment: 6 pages, 5 figure