Reply: Self-Incrimination and the Constitution: A Brief Rejoinder to Professor Kamisar

A Reply to Yale Kamisar\u27s Response to the Fifth Amendment Principles: The Self-Incrimination Claus

Fifth Amendment First Principles: The Self-Incrimination Clause

In Part I of this article, we examine the global puzzle of the Self-Incrimination Clause and the local confusion or perversion lurking behind virtually every key word and phrase in the clause as now construed. In Part II we elaborate our reading of the clause and show how it clears up the local problems and solves the overall puzzle

Energy conservation improvement of the existing building park, constraints and challenges: case of granite traditional constructions in the United Kingdom.

The increase in energy price has sparked a debate in the UK as to what would be the best way to address this problem. The British Prime Minister gave a straightforward and radical answer, suggesting that, existing building stock should be improved to reach a certain standard. The goal is to reduce the energy consumption to ensure a reduction in the running cost of household asset in the UK. The government initiative was to make grants available to dwellings that shows a lack of energy efficiency this includes the increase of insulation of the buildings envelop as well as renewable energy generator and end use equipments. The CO2 emissions per capita and the reduction of the national dependency on finite fossil fuel resources are achievable via major refurbishment programmes of both owners occupied and rented properties. Many of the easy measures have been done, leaving only the major areas that need addressing. These areas are complex and expensive therefore home owners and private landlords are deterred from addressing them. Incremental improvements are no longer cost or physically effective, however; therefore a holistic and integrated approach to buildings refurbishment is required. Dealing with the existing building stock will become an important topic for architects, town planners and civil engineers [1]. The aim of this research is to present the different possible scenarios of refurbishment based on the most popular building typologies in the UK

Virtual microfluidic traps, filters, channels and pumps using Marangoni flows

"This paper describes how Marangoni flows of various forms can be generated in thin liquid films for the purposes of microfluidic manipulation. Several microfluidic components, including traps, channels, filters and pumps, for manipulating aqueous droplets suspended in a film of oil on blank, unpatterned substrates are demonstrated. These are 'virtual' devices because they have no physical structure; they accomplish their function entirely by localized variations in surface tension (Marangoni flows) created in a non-contact manner by heat sources suspended just above the liquid surface. Various flow patterns can be engineered through the geometric design of the heat sources on size scales ranging from 10 to 1000 um. A point source generates toroidal flows which can be used for droplet merging and mixing. Virtual channels and traps, emulated by linear and annular heat fluxes, respectively, demonstrate nearly 100% size selectivity for droplets ranging from 300 to 1000 um. A source of heat flux that is parallel to the surface and is triangular with a 10deg taper serves as a linear pump, translating droplets of about the same size at speeds up to 200 um s[?]1. The paper includes simulations that illuminate the working principle of the devices. Models show that Marangoni flows scale favorably to small length scales. By using microscale thermal devices delivering sharp temperature gradients, it is possible to generate mm s[?]1 flow velocities with only small increases (<1deg) in liquid temperature."http://deepblue.lib.umich.edu/bitstream/2027.42/64184/1/jmm8_11_115031.pd

Claudin Family of Proteins and Cancer: An Overview

Tight junctions are the apical cell-cell adhesion that regulate paracellular permeability and are critical for epithelial cell polarity. Molecular architecture of tight junction has been studied extensively, which has confirmed that claudin family of proteins is integral component of tight junction. Loss of cell-cell adhesion is central to the cellular transformation and acquisition of metastatic potential; however, the role of claudin family of proteins play in a series of pathophysiological events, including human carcinoma development, is only now beginning to be understood. Several claudin mouse knockout models have been generated and the diversity of phenotypes observed clearly demonstrates their important roles in the maintenance of tissue integrity in various organs and suggest that claudins also participate in cellular contexts other than tight junctions. The mechanisms of claudin regulation and their exact roles in normal physiology and disease are being elucidated, but much work remains to be done. In this review, we have discussed the conceptual framework concerning claudins and their potential implication in cancer. We predict that next several years will likely witness a boom in our understanding of the potential role of claudins in the regulation of tumorigenesis, which may, in turn, provide new approaches for the targeted therapy

Traitements d'effluents issus de l'industrie de la pêche par un procédé de coagulation/floculation

La présente étude porte sur le traitement physico-chimique d'un effluent industriel chargé d'encre de seiche issu de l'industrie de conditionnement des produits de la pêche. Différentes combinaisons de coagulant -floculant ont été étudiées. Le sulfate d'aluminium (SA), divers polyélectrolytes et certains adjuvants pulvérulents ont été utilisés. L'efficacité du traitement par coagulation-floculation a été analysée en suivant l'évolution de la turbidité et de la DCO résiduelle du surnageant.Les résultats de cette étude ont révélé qu'à pH 6-7, l'addition de SA à une concentration supérieure à 1000 mg.l-1 entraîne la coagulation des particules d'encre de seiche. L'addition d'un polyélectrolyte en association avec le SA permet de réduire la concentration requise en SA à environ 300 mg.l-1, tout en améliorant l'efficacité du processus de coagulation-floculation. Le recours à un adjuvant pulvérulent en combinaison avec le SA et un polyélectrolyte accroît notablement les performances du traitement et permet d'obtenir un effluent ayant une turbidité résiduelle de 7 NTU.The aim of this work was to compare the efficiency of a coagulation-flocculation process using different systems individually or in combination. The waste water used was an industrial cuttlefish effluent principally composed of colloidal particles from the cuttlefish. The initial turbidity and chemical oxygen demand were approximately 700 NTU and 22,000 mg×L-1 respectively. Two parameters were used to assess the process efficiency: the residual turbidity and the chemical oxygen demand (COD) of the supernatant.Three systems were investigated: aluminium sulphate (SA), polyelectrolytes and a ternary combination of SA-polyelectrolyte and colloidal microparticle adjuvant. Results demonstrated that at pH 6-7, SA caused some coagulation of the suspension, but the dosage required (about 1000 mg×L-1) far exceeded those conventionally used in water treatment. As a consequence, an appreciable amount of SA, which was above the authorised limits, remained in the supernatant. Indeed, adsorption isotherm measurements revealed that at pH 6.5-7 the residual proportion of SA attained was about 20%. The addition of polyelectrolytes in combination with SA allowed reduction of the SA dosage to 150 mg×L-1. Amongst the polymers tested, the cationic polymer was the most efficient. The ability to bring about flocculation was positively related to the molecular weight, which is in agreement with a bridging flocculation mechanism. Starch, a natural, low-cost polymer was also an efficient flocculent even though it is a non-charged polymer. The ability of starch to bring about a flocculation action was explained by its relatively low solubility, which leads to some aggregation of macromolecular chains that act as anchoring sites for the coagulated ink particles. With this system, a double treatment in the presence of 150 mg×L-1 SA and 25 mg×L-1 polydiallyldimethylammonium chloride (PDMAC) or starch lead to a supernatant with a turbidity and COD of 150 NTU and 5500 mg×L-1 respectively.The third part of our study was concerned with the effect of the addition of an insoluble microparticle adjuvant in combination with SA and polyelectrolytes. Different components were investigated, but among them only colloidal silica and MgO bring about a significant enhancement of the flocculation process. This effect was explained by a bridging mechanism in which the adjuvant microparticles act as sites that favour the anchoring of the coagulated ink particles. Using a triple treatment in the presence of 150 mg×L-1 SA, 25 mg×L-1 PDMAC and 0.75 g×L-1 MgO removed about 95 % of the ink particles. The supernatant obtained was characterised by a low turbidity value (about 7 NTU) and a COD value about 2000 mg×L-1

Power Approaches for Implantable Medical Devices.

Implantable medical devices have been implemented to provide treatment and to assess in vivo physiological information in humans as well as animal models for medical diagnosis and prognosis, therapeutic applications and biological science studies. The advances of micro/nanotechnology dovetailed with novel biomaterials have further enhanced biocompatibility, sensitivity, longevity and reliability in newly-emerged low-cost and compact devices. Close-loop systems with both sensing and treatment functions have also been developed to provide point-of-care and personalized medicine. Nevertheless, one of the remaining challenges is whether power can be supplied sufficiently and continuously for the operation of the entire system. This issue is becoming more and more critical to the increasing need of power for wireless communication in implanted devices towards the future healthcare infrastructure, namely mobile health (m-Health). In this review paper, methodologies to transfer and harvest energy in implantable medical devices are introduced and discussed to highlight the uses and significances of various potential power sources

Design and Development of the Biped Prototype ROBIAN

Proceedings of the 2002 IEEE International Conference on Robotics & Automation, Washington, DC, May 200