6 research outputs found
The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial
Background/objective
Irisin is suggested to be an exercise beneficial effects mediator. This study aimed to examine the effects of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the plasma levels of irisin and some metabolic and anthropometric indices.
Methods
Sixty overweight women with metabolic syndrome were assigned equally into four groups: AE, RE, CE, and control. The study variables were measured before and 24 h after the intervention period.
Results
None of the study groups showed statistically significant changes in the serum irisin. However, muscle mass significantly increased in the RE and CE groups. Also, a significant decrease was observed in the body fat percentage in all groups. In addition, compared with the control group, the homeostatic model assessment of insulin resistance in the AE (p = 0.021), RE (p = 0.039), and in the CE (p = 0.003) groups reduced significantly. According to the analysis of indicesâ changes, serum irisin was significantly correlated with the body fat percentage (r = 0.532) and HOMA-IR (r = 0.424).
Conclusions
The systematic exercise program for 8-weeks did not change circulating irisin and no statistically significant difference was observed between the exercise methods. Also, serum irisin seemed to be associated with the glycemic status, body fat and weight independent of exercise activity.publishedVersionUnit Licence Agreemen
Neurological manifestations as the predictors of severity and mortality in hospitalized individuals with COVID-19: a multicenter prospective clinical study
BACKGROUNDS: The reports of neurological symptoms are increasing in cases with coronavirus disease 2019 (COVID-19). This multi-center prospective study was conducted to determine the incidence of neurological manifestations in hospitalized cases with COVID-19 and assess these symptoms as the predictors of severity and death.
METHODS: Hospitalized males and females with COVID-19 who aged over 18âyears were included in the study. They were examined by two neurologists at the time of admission. All survived cases were followed for 8 weeks after discharge and 16âweeks if their symptoms had no improvements.
RESULTS: We included 873 participants. Of eligible cases, 122 individuals (13.97%) died during hospitalization. The most common non-neurological manifestations were fever (81.1%), cough (76.1%), fatigue (36.1%), and shortness of breath (27.6%). Aging, male gender, co-morbidity, smoking, hemoptysis, chest tightness, and shortness of breath were associated with increased odds of severe cases and/or mortality. There were 561 (64.3%) cases with smell and taste dysfunctions (hyposmia: 58.6%; anosmia: 41.4%; dysguesia: 100%). They were more common among females (69.7%) and non-smokers (66.7%). Hyposmia/anosmia and dysgeusia were found to be associated with reduced odds of severe cases and mortality. Myalgia (24.8%), headaches (12.6%), and dizziness (11.9%) were other common neurological symptoms. Headaches had negative correlation with severity and death due to COVID-19 but myalgia and dizziness were not associated. The cerebrovascular events (nâ=â10) and status epilepticus (nâ=â1) were other neurological findings. The partial or full recovery of smell and taste dysfunctions was found in 95.2% after 8 weeks and 97.3% after 16âweeks. The parosmia (30.9%) and phantosmia (9.0%) were also reported during 8âweeks of follow-up. Five cases with mild headaches and 5 cases with myalgia were reported after 16âweeks of discharge. The demyelinating myelitis (nâ=â1) and Guillain-BarrĂ© syndrome (nâ= 1) were also found during follow-up.
CONCLUSION: Neurological symptoms were found to be prevalent among individuals with COVID-19 disease and should not be under-estimated during the current pandemic outbreak
Subcutaneous Connective Tissue Reactions to Various Endodontic Biomaterials: An Animal Study
Background and aims. Biocompatibility of root-end filling materials is a matter of debate. The aim of this study was to
compare the biocompatibility of a variety of commercial ProRoot WMTA cements and a resin-based cement (GeristoreÂź)
with different pH values of setting reaction and different aluminum contents, implanted into the subcutaneous connective
tissue of rats at various time intervals.
Materials and methods. Fifty Sprague-Dawley rats were used in this study. Polyethylene tubes were filled with Angelus
WMTA, ProRoot WMTA, Bioaggregate, and Geristore. Empty control tubes were implanted into subcutaneous tissues
and harvested at 7-, 14-, 28- and 60-day intervals. Tissue sections of 5 ÎŒm were stained with hematoxylin and eosin and
observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells); 1,
mild (inflammatory cells â€25); 2, moderate (25â125 inflammatory cells); and 3, severe (>125 inflammatory cells). Statistical
analysis was performed with Kruskal-Wallis and Mann Whitney U tests.
Results. ProRoot WMTA and Angelus elicited significantly less inflammation than other materials (P<0.05). After 7 days,
however, all the materials induced significantly more inflammation than the controls (P<0.05). Angelus-MTA group exhibited
no significant differences from the Bioaggregate group (P=0.15); however, ProRoot WMTA elicited significantly less
inflammation than Bioaggregate (P=0.02). Geristore induced significantly more inflammation than other groups (P<0.05).
Conclusion. Geristore induced an inflammatory response higher than ProRoot WMTA; therefore, it is not recommended
for clinical use
The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome : A randomized control trial
Background/objective
Irisin is suggested to be an exercise beneficial effects mediator. This study aimed to examine the effects of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the plasma levels of irisin and some metabolic and anthropometric indices.
Methods
Sixty overweight women with metabolic syndrome were assigned equally into four groups: AE, RE, CE, and control. The study variables were measured before and 24 h after the intervention period.
Results
None of the study groups showed statistically significant changes in the serum irisin. However, muscle mass significantly increased in the RE and CE groups. Also, a significant decrease was observed in the body fat percentage in all groups. In addition, compared with the control group, the homeostatic model assessment of insulin resistance in the AE (p = 0.021), RE (p = 0.039), and in the CE (p = 0.003) groups reduced significantly. According to the analysis of indicesâ changes, serum irisin was significantly correlated with the body fat percentage (r = 0.532) and HOMA-IR (r = 0.424).
Conclusions
The systematic exercise program for 8-weeks did not change circulating irisin and no statistically significant difference was observed between the exercise methods. Also, serum irisin seemed to be associated with the glycemic status, body fat and weight independent of exercise activity