HUBUNGAN ANTARA KEPATUHAN MINUM OBAT DENGAN TEKANAN DARAH PASIEN HIPERTENSI DI PUSKESMAS PEMURUS BARU BANJARMASIN

Latar belakang : Salah satu faktor yang mempengaruhi keberhasilan terapi hipertensi adalah kepatuhan minum obat. Kepatuhan minum obat dapat membuat tekanan darah pasien hipertensi terkontrol dalam nilai normal. Tujuan penelitian ini adalah untuk untuk mengetahui tingkat kepatuhan minum obat, gambaran tekanan darah, dan korelasi antara kepatuhan minum obat dengan tekanan darah pasien hipertensi di Puskesmas Pemurus Baru Banjarmasin. Metode : Penelitian ini menggunakan desain non eksperimental obsevasional. Pengumpulan data dilakukan secara prospektif. Jumlah sampel pada penelitian ini adalah 111 pasien hipertensi. Metode pengambilan sampel menggunakan teknik total sampling. Data kepatuhan minum obat dikumpulkan menggunakan kuesioner MMAS, data tekanan darah didapatkan dari hasil pengukuran yang tercantum pada rekam medis dan diklasifikan menjadi tingkat hipertensi. Uji distribusi frekuensi untuk mengklasifikasikan tingkat kepatuhan dan tingkat hipertensi. Uji korelasi Spearman untuk mengetahui korelasi antara tingkat kepatuhan dengan tingkat hipertensi. Hasil : Tingkat kepatuhan minum obat mayoritas adalah tingkat kepatuhan minum obat rendah (78,4%), kemudian tingkat kepatuhan tinggi (14,4%), dan tingkat kepatuhan sedang (7,2%). Mayoritas sampel tergolong dalam hipertensi tingkat II (45,9%), kemudian hipertensi tingkat I (36,1%), pre hipertensi (16,2%), dan normal (1,8%). Terdapat korelasi yang bermakna antara kepatuhan minum obat dengan tingkat hipertensi, arah korelasi negatif, dan kekuatan korelasi lemah (R = -0,264). Simpulan : Tingkat kepatuhan minum obat mayoritas adalah tingkat kepatuhan minum obat rendah. Mayoritas sampel tergolong memiliki hipertensi tingkat II. Adanya korelasi yang lemah antara tingkat kepatuhan minum obat dengan tekanan darah (tingkat hipertensi). Kata kunci : hipertensi, kepatuhan minum obat, tekanan darah. Kepustakaan : 34 (2008-2020

Torbangun Leaves (Coleus amboinicus Lour) Powder Capsules Supplementation Improve Lipid Profile and Blood Pressure in Men with Hypercholesterol

The aim of this study was to analyze the effect of torbangun leaves powder capsules supplementation on lipid profile and blood pressure in men with hypercholesterol. This study was a single blind randomized control trial design with 26 male subjects. The inclusion criterias for subject were adults (age 25-55 years), blood total cholesterol levels ≥200 mg/dl, and signed the informed consent. Subjects were divided into two groups of one intervention (torbangun capsules) and one control (amylum) group. The intervention of 750 mg/day torbangun powder for the intervention group and 300 mg/day amylum for control group were administered for 28 days. The analysis of lipid profile results showed that the trygliseride, LDL, and HDL were not significantly affected by the torbangun intervention but it significantly decreased the total cholesterol level. The supplementation of torbangun capsules also decreased the sistolic blood pressure significantly. but not in diastolic pressure

Autosomal dominant Emery-Dreifuss muscular dystrophy caused by a mutation in the lamin A/C gene identified by exome sequencing: a case report

Background: Emery-Dreifuss Muscular Dystrophy (EDMD) is an uncommon genetic disease among the group of muscular dystrophies. EDMD is clinically heterogeneous and resembles other muscular dystrophies. Mutation of the lamin A/C (LMNA) gene, which causes EDMD, also causes many other diseases. There is inter and intrafamilial variability in clinical presentations. Precise diagnosis can help in patient surveillance, especially before they present with cardiac problems. Hence, this paper shows how a molecular work-out by next-generation sequencing can help this group of disorders. Case presentation: A 2-year-10-month-old Javanese boy presented to our clinic with weakness in lower limbs and difficulty climbing stairs. The clinical features of the boy were Gower’s sign, waddling gait and high CK level. His father presented with elbow contractures and heels, toe walking and weakness of limbs, pelvic, and peroneus muscles. Exome sequencing on this patient detected a pathogenic variant in the LMNA gene (NM_170707: c.C1357T: NP_733821: p.Arg453Trp) that has been reported to cause Autosomal Dominant Emery-Dreifuss muscular dystrophy. Further examination showed total atrioventricular block and atrial fibrillation in the father. Conclusion: EDMD is a rare disabling muscular disease that poses a diagnostic challenge. Family history work-up and thorough neuromuscular physical examinations are needed. Early diagnosis is essential to recognize orthopaedic and cardiac complications, improving the clinical management and prognosis of the disease. Exome sequencing could successfully determine pathogenic variants to provide a conclusive diagnosis