Lo smeraldo di Mario Soldati tra surrealismo e distopia

Lo smeraldo di Mario Soldati pu\uf2 essere appieno inserito in quell'atmosfera di grande sera del mondo, cui fa riferimento Bruno Pischedda in relazione alla letteratura italiana degli anni Settanta, la quale reagisce con una cultura apocalittica e un anticapitalismo romantico alla repulsione del moderno. La sfera distopica del romanzo \ue8 interpretabile tramite la categoria della lontananza attuata per mezzo dell'espediente del sogno. Il senso della fine \ue8 relegato nella dimensione onirica come passaggio necessario per la ricomposizione dell'io. Il lavoro di ricerca \ue8 incentrato sullo studio delle fonti principali del romanzo in seno all'individuazione della matrice epico-avventurosa quale componente sostanziale dell'opera: gli autori coinvolti sono Ariosto e Stevenson, che lo scrittore cita direttamente e indirettamente nel corso dell'opera quali modelli ben presenti e prolifici nel proprio immaginario di sempre. In merito alla componente del mistero i modelli indagati sono quelli di Faust e Don Giovanni, quali miti moderni del desiderio nella sua duplice ascendenza verso il sapere e verso il piacere. Viene presa altres\uec in considerazione la memoria interna dell'autore, vale a dire l'influenza esercitata ne Lo smeraldo dalle opere precedenti dello stesso Soldati, individuando il romanzo in questione come una summa delle esperienze biografiche e letterarie dello scrittore. Importante \ue8 stata la consultazione del materiale archivistico conservato presso l'archivio Soldati del centro Apice di Milano. In particolare \ue8 stata presa in esame, e in parte inserita in appendice alla presente tesi, la sceneggiatura inedita de Il diavolo in bottiglia, tratta dall'omonimo racconto di Stevenson, in quanto alcuni elementi, messi in relazione con Lo smeraldo, si sono rivelati utili spunti di riflessione sull'opera soldatiana

Strategies for elimination of rubella in pregnancy and of congenital rubella syndrome in high and upper-middle income countries

Rubella infection generally leads to mild symptoms; otherwise, in pregnant women it can cause severe damages. The only way to prevent rubella is vaccine. Before the introduction of the vaccine, up to 4 babies in 1000 live births were born with CRS.This work aims to review the most important strategies for the elimination of CRS in upper and high-income countries.Papers were selected through a PubMed search up to January 2019, using keywords rubella, congenital rubella syndrome and epidemiology. Articles published in the last 12 years and referred to upper income and high-income countries in title or abstract were included.Sixty-five papers were selected dealing with one or more of the following strategies: increasing of rubella vaccination coverage in childbearing age women, males, immigrants; exploitation of all appropriate occasions; improving of rubella surveillance.Despite numerous suggestions and indications for valid strategies to eliminate rubella in pregnancy and congenital rubella syndrome, a practical application is often missing

Association Between ERCC1 rs3212986 and ERCC2/XPD rs1799793 and OS in Patients With Advanced Esophageal Cancer

Esophageal cancer (EC) is a very aggressive tumor, and no reliable prognostic markers exist especially for resectable advanced neoplasia. The principal aim of this study was to investigate the association of germline polymorphisms in nucleotide excision repair (NER) pathway genes with the overall survival (OS) of patients with advanced EC. As a second aim, we also studied the association of NER gene variants with response to cisplatin-based chemotherapy. Among the EC patients referred to our Institution between 2004 and 2012, we selected a cohort of 180 patients diagnosed with a clinical tumor stage ranging from IIB and IVA. Patients were genotyped for four NER variants, two in the ERCC1 (rs11615 and rs3212986) and two in the ERCC2/XPD (rs1799793 and rs13181) genes. Kaplan–Meier analyses and Cox proportional hazards model were used to evaluate the associations of the selected variants with OS; association with response to neoadjuvant therapy was investigated using logistic regression. Results showed that the ERCC1 rs3212986 and the ERCC2/XPD rs1799793 were significantly associated with shorter OS. On the contrary, response association analysis displayed that, while rs11615 and rs3212986 in ERCC1 were associated with response, both ERCC2/XPD variants were not. By creating survival prediction models, we showed that the rs3212986 and the rs1799793 have a better predictability of the tumor stage alone. Furthermore, they were able to improve the power of the clinical model (AUC = 0.660 vs. AUC = 0.548, p = 0.004). In conclusion, our results indicate that the ERCC1 rs3212986 and the ERCC2/XPD rs1799793 could be used as surrogate markers for a better stratification of EC patients with advanced resectable tumor

Epidemiological study in an area contaminated by chromium, arsenic, mercury and boron in Tuscany region

The Cecina river valley, in Tuscany, is characterized by environmental chromium contamination; Cr(VI) concentrations in ground and surface waters exceeds the WHO limit for drinking water. Boron, arsenic, mercury contaminations, of natural or industrial origin,pesticides use, and waste landfilling are causes of community concern. Statistically significant mortality excesses resulted for circulatory diseases in men(Obs=1788, SMR=1.06) and women (Obs=2111, SMR=1.10), colon cancer in women (Obs=44, SMR=1.38), stomach cancer in men (Obs=42, SMR=1.43). Statistically significant hospitalization excesses resulted for respiratory diseases in men (Obs=585, SHR=1.15), chronic respiratory diseases in women (Obs=88, SHR=1.71), digestive diseases in men (Obs=766, SHR=1.13) and women (Obs=565, SHR=1.13),lynphohematopoietic diseases in women (Obs=217, SHR=1.15). The results are useful to plan advanced environmental and epidemiological studies, to open dialogue with local representatives, to promote future remediation activities and to enforce recommendations

Right- vs. left-sided metastatic colorectal cancer: Differences in tumor biology and bevacizumab efficacy

There is evidence of a different response to treatment with regard to the primary tumor localization (right-sided or left-sided) in patients with metastatic colorectal cancer (mCRC). We analyzed the different outcomes and biomolecular characteristics in relation to tumor localization in 122 of the 370 patients with metastatic colorectal cancer enrolled onto the phase III prospective multicenter “Italian Trial in Advanced Colorectal Cancer (ITACa)”, randomized to receive first-line chemotherapy (CT) or CT plus bevacizumab (CT + B). RAS and BRAF mutations; baseline expression levels of circulating vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), cyclooxygenase-2 (COX2), ephrin type-B receptor 4 (EPHB4), hypoxia-inducible factor 1-alpha (HIF-1α), lactate dehydrogenase (LDH), and high-sensitivity C reactive protein (hs-CRP); and inflammatory indexes such as the neutrophil-to-lymphocyte ratio, platelet-lymphocyte rate and systemic immune-inflammation index were evaluated. Patients with right-sided tumors showed a longer median progression-free survival in the CT + B arm than in the CT group (12.6 vs. 9.0 months, respectively, p = 0.017). Baseline inflammatory indexes were significantly higher in left-sided tumors, whereas eNOS and EPHB4 expression was significantly higher and BRAF mutation more frequent in right-sided tumors. Our data suggest a greater efficacy of the CT + B combination in right-sided mCRC, which might be attributable to the lower inflammatory status and higher expression of pro-angiogenic factors that appear to characterize these tumors

Rapporto - Progetto di ricerca Epidemiologica sulle popolazioni residenti nell\u27intero bacino Geotermico Toscano " Progetto Geotermia"

xx

Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, we explored the pleiotropy of these 25 loci. Finally, in a subset of individuals with epilepsy and detailed clinical data available, we performed phenome-wide association analyses between individual CNVs and clinical annotations categorized through the Human Phenotype Ontology (HPO). For six CNVs, we identified 19 significant associations with specific HPO terms and generated, for all CNVs, phenotype signatures across 17 clinical categories relevant for epileptologists. This is the most comprehensive investigation of CNVs in epilepsy and related seizure disorders, with potential implications for clinical practice

Punti impropri nella robotica mobile

Negli ultimi decenni molti autori hanno affrontato varie sfide per quanto riguarda la navigazione autonoma di robot e sono state proposte diverse soluzioni per superare le difficoltà di piattaforme di navigazioni intelligenti. Con questo elaborato vogliamo ricercare gli obiettivi principali della navigazione di robot e tra questi andiamo ad approfondire la stima della posa di un robot o di un veicolo autonomo. La maggior parte dei metodi proposti si basa sul rilevamento del punto di fuga che ricopre un ruolo importante in questo campo. Abbiamo analizzato alcune tecniche che stimassero la posizione del robot in primo luogo nell’ambiente interno e presentiamo in particolare un metodo che risale al punto di fuga basato sulla trasformata di Hough e sul raggruppamento K-means. In secondo luogo presentiamo una descrizione generale di alcuni aspetti della navigazione su strade e su ambienti pedonali

Predictive role of host constitutive variants in neoadjuvant therapy of esophageal cancer

Chemoradiotherapy followed by surgery is at present the standard therapeutic approach for esophageal cancer (EC) in patients with resectable tumor. However, response to neoadjuvant therapy is characterized by a strong interpatient variability, and the identification of markers predictive of outcome is mandatory. In this review, taking into account the currently available literature, we report the impact that host genetic variables can have on EC neoadjuvant therapy. We mainly focused on the gene variants involved in the pharmacokinetics and pharmacodynamics of the common chemotherapeutic drugs used to treat EC patients, commented on the weakness of the present knowledge, and discussed the future strategies to achieve a more personalized and effective EC treatment

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura

The role of rituximab, a chimeric monoclonal antibody directed against the CD20 antigen, in the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP) has not been determined. The effectiveness and side effects of this therapeutic modality were investigated in a cohort of 25 individuals with chronic ITP. All patients had ITP that had been resistant to between 2 and 5 different therapeutic regimens, including 8 patients who had already failed splenectomy. Patients were scheduled to receive intravenous rituximab at the dose of 375 mg/m(2) once weekly for 4 weeks. Rituximab infusion-related side effects were observed in 18 patients, but were of mod-est intensity and did not require discontinuation of treatment. A complete response (platelet count greater than 100 x 10(9)/L) was observed in 5 cases, a partial response (platelet count between 50 and 100 x 10(9)/L) in 5 cases, and a minor response (platelet count below So x 10(9)/L, with no need for continued treatment) in 3 cases, with an overall response rate of 52%. In 7 cases, responses were sustained (6 months or longer). In 2 patients with relapsed disease, repeat challenge with rituximab induced a new response. In patients with a complete or partial response, a significant rise in platelet concentrations was observed early during the course of treatment, usually 1 week after the first rituximab infusion. No clinical or laboratory parameter was found to predict treatment outcome, although there was a suggestion that women and younger patients have a better chance of response. In conclusion, rituximab therapy has a limited but valuable effect in patients with chronic ITP. In view of its mild toxicity and the lack of effective alternative treatments, its use in the setting of chronic refractory ITP is warranted. (C) 2001 by The American Society of Hematology