Segurança Na Mudança Direta De Natalizumabe Para Fingolimode Em Um Grupo De Pacientes Com Esclerose Múltipla E Positivos Para Jcv

To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods: Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results: After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reported. Conclusion: Washout may not be necessary in daily practice when switching from natalizumab to fingolimod. Expertise on multiple sclerosis management, however, is essential for drug switching. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All Rights Reserved.74865065

The Impact Of Diagnostic Criteria For Neuromyelitis Optica In Patients With Ms: A 10-year Follow-up Of The South Atlantic Project

Background: It is recognized that there is a particular geographic and ethnic distribution of neuromyelitis optica (NMO) among Caucasian and non-Caucasian populations. Objective: To review the diagnoses of patients whom were enrolled in the South Atlantic Project, a Brazilian multiple sclerosis (MS) survey performed from 1995-1998, and to identify NMO and MS case frequencies. Methods: We reviewed the data from a 10-year follow-up of MS patients. To apply the current diagnostic criteria, the neurologists were asked to collect clinical and laboratory data from the medical records of study patients treated from 1999-2009. Results: The spectrum of inflammatory demyelinating disease in 322 patients (67% white; 33% African-Brazilian) was: 49 (15%) with NMO; 14 (4%) with NMO syndromes; 10 (3%) with acute disseminated encephalomyelitis (ADEM); one isolated tumefactive brain lesion; 249 (77%) with MS (151 with relapsing-remitting MS (RRMS), 70 with secondary progressive MS (SPMS) and 27 with primary progressive MS (PPMS)). Disability was more severe in NMO and PPMS. One-third of the NMO patients had died. Conclusions: The frequency of NMO was 6.8% in São Paulo and 20.5% in Rio de Janeiro, and mainly seen in persons of African descent, which strengthens the hypothesis of there being an ethnic association of this disease. We recommend that epidemiological studies on MS that were performed previously be reviewed again, to ensure more accurate diagnoses. © 2014 The Author(s).203374381Weinshenker, B.G., Epidemiology of multiple sclerosis Neurol Clin, 14 (1996), pp. 291-308Wingerchuk, D.W., Weinshenker, B.G., Raine, C.S., McFarland, H.F., Hohlfeld, R., (2008) Multiple Sclerosis: A Comprehensive Text, , Philadelphia: Saunders Elsevier;McDonald, W.I., Compston, A., Edan, G., Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis (2001) Ann Neurol, 50, pp. 121-127Polman, C.H., Reingold, S.C., Edan, G., Filippi, M., Hartung, H.-P., Kappos, L., Lublin, F.D., Wolinsky, J.S., Diagnostic criteria for multiple sclerosis: 2005 Revisions to the McDonald Criteria (2005) Annals of Neurology, 58 (6), pp. 840-846. , DOI 10.1002/ana.20703Polman, C.H., Reingold, S.C., Banwell, B., Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria (2010) Ann Neurol, 69, pp. 292-302Miller, D.H., Weinshenker, B.G., Filippi, M., Differential diagnosis of suspected multiple sclerosis: A consensus approach (2008) Mult Scler, 14, pp. 1157-1174Mandler, R.N., Davis, L.E., Jeffery, D.R., Kornfeld, M., Devic's neuromyelitis optica: A clinicopathological study of 8 patients (1993) Annals of Neurology, 34 (2), pp. 162-168O'Riordan, J.I., Gallagher, H.L., Thompson, A.J., Howard, R.S., Kingsley, D.P.E., Thompson, E.J., McDonald, W.I., Miller, D.H., Clinical, CSF, and MRI findings in Devic's neuromyelitis optica (1996) Journal of Neurology Neurosurgery and Psychiatry, 60 (4), pp. 382-387Wingerchuk, D.M., Hogancamp, W.F., O'Brien, P.C., Weinshenker, B.G., The clinical course of neuromyelitis optica (Devic's syndrome) (1999) Neurology, 53 (5), pp. 1107-1114Papais-Alvarenga, R.M., Miranda-Santos, C.M., Puccioni-Sohler, M., Optic neuromyelitis syndrome in Brazilian patients (2002) J Neurol Neurosurg Psychiatry, 73, pp. 429-435De Seze, J., Stojkovic, T., Ferriby, D., Gauvrit, J.-Y., Montagne, C., Mounier-Vehier, F., Verier, A., Vermersch, P., Devic's neuromyelitis optica: Clinical, laboratory, MRI and outcome profile (2002) Journal of the Neurological Sciences, 197 (1-2), pp. 57-61. , DOI 10.1016/S0022-510X(02)00043-6, PII S0022510X02000436Wingerchuk, D.M., Lennon, V.A., Pittock, S.J., Lucchinetti, C.F., Weinshenker, B.G., Revised diagnostic criteria for neuromyelitis optica (2006) Neurology, 66 (10), pp. 1485-1489. , DOI 10.1212/01.wnl.0000216139.44259.74, PII 0000611420060523000008Lennon, P.V.A., Wingerchuk, D.M., Kryzer, T.J., Pittock, S.J., Lucchinetti, C.F., Fujihara, K., Nakashima, I., Weinshenker, B.G., A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis (2004) Lancet, 364 (9451), pp. 2106-2112. , DOI 10.1016/S0140-6736(04)17551-X, PII S014067360417551XLennon, V.A., Kryzer, T.J., Pittock, S.J., Verkman, A.S., Hinson, S.R., IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel (2005) Journal of Experimental Medicine, 202 (4), pp. 473-477. , http://www.jem.org/cgi/reprint/202/4/473, DOI 10.1084/jem.20050304Kira, J.-I., Multiple sclerosis in the Japanese population (2003) Lancet Neurology, 2 (2), pp. 117-127. , DOI 10.1016/S1474-4422(03)00308-9Cabre, P., Gonzalez-Quevedo, A., Lannuzel, A., Descriptive epidemiology of neuromyelitis optica in the Caribbean Basin (2002) Rev Neurol, 165, pp. 676-683Cabrera-Gomez, J.A., Kurtzke, J.F., Gonzalez-Quevedo, A., An epidemiological study of neuromyelitis optica in Cuba (2009) J Neurol, 256, pp. 35-44Asgari, N., Lillevang, S.T., Hpb, S., A population-based study of neuromyelitis optica in Caucasians (2011) Neurology, 76, pp. 1589-1595Cossburn, M., Tackley, G., Baker, K., The prevalence of neuromyelitis optica in South East Wales Eur J Neurol Eur J Neurol, 19, pp. 655-659Cabre, P., Heinzlef, O., Merle, H., Buisson, G.G., Bera, O., Bellance, R., Vernant, J.C., Smadja, D., MS and neuromyelitis optica in Martinique (French West Indies) (2001) Neurology, 56 (4), pp. 507-514Rivera, J.F., Kurtzke, J.F., Booth, V.J., Characteristics of Devic's disease (neuromyelitis optica) in Mexico (2008) J Neurol, 255, pp. 710-715Wu, J.S., Zhang, M.N., Carroll, W.M., Characterization of the spectrum of demyelinating disease in Western Australia (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1022-1026Bizzoco, E., Lolli, F., Repice, A.M., Prevalence of neuromyelitis optica spectrum disorder and phenotype distribution (2009) J Neurol, 256, pp. 1891-1898Papais-Alvarenga, R.M., Leon Alves, S., Tilbery, C.P., (2002) Esclerosis Multipla - Una Mirada Ibero Latino Americana, pp. 35-45. , Nogales-Gaete CARJ, ed. New York: DEMOS;Papais-Alvarenga, R.M., Leon Alves, S., Tilbery, C.P., SIAPEM: A Brazilian software database for multiple sclerosis research in tropical countries (2003) African J Neurol SciKurtzke, J.F., Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology, 33 (11), pp. 1444-1452Corona, T., Roman, G.C., Multiple sclerosis in Latin America (2006) Neuroepidemiology, 26 (1), pp. 1-3. , DOI 10.1159/000089230Melcolm Cristiano, E., Patrucco, L., Rojas, J.I., A systematic review of the epidemiology of multiple sclerosis in South America (2008) Eur J Neurol, 15, pp. 1273-1278Asgari, N., Owens, T., Frokiaer, J., Neuromyelitis optica (NMO), an autoimmune disease of the central nervous system (CNS) (2011) Acta Neurol Scand, 123, pp. 369-384Collongues, N., De Seze, J., Current and future treatment approaches for neuromyelitis optica (2011) Adv Neurol Disord, 4, pp. 111-121Rubiera, M., Rio, J., Tintore, M., Nos, C., Rovira, A., Tellez, N., Montalban, X., Neuromyelitis optica diagnosis in clinically isolated syndromes suggestive of multiple sclerosis (2006) Neurology, 66 (10), pp. 1568-1570. , DOI 10.1212/01.wnl.0000216233.56611.c2, PII 000061142006052300002

Multiple Sclerosis In South America: Month Of Birth In Different Latitudes Does Not Seem To Interfere With The Prevalence Or Progression Of The Disease [esclerose Múltipla Na América Do Sul: Mês De Nascimento Em Diferentes Latitudes Não Parece Interferir Com A Prevalência Ou Progressão Da Doença]

Objective: To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods: Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results: Analysis of data from 1207 MS patients and 1207 control subjects did not show any significant variation in the month of birth regarding the prevalence of MS in four latitude bands (0-10; 11-20; 21-30; and 31-40 degrees). There was no relationship between the month of birth and the severity of disease in each latitude band. Conclusion: The results from this study show that MS patients born to mothers who were pregnant at different Southern latitudes do not follow the seasonal pattern observed at high Northern latitudes.719:00 AM573579Templer, D.I., Trent, N.H., Spencer, D.A., Season of birth in multiple sclerosis (1992) Acta Neurol Scand, 85, pp. 107-109Bharanidharan, P., Monthly distribution of multiple sclerosis patients' births (1997) Int J Biometeorol, 40, pp. 117-118Salemi, G., Ragonese, P., Aridon, P., Is season of birth associated with multiple sclerosis? (2000) Acta Neurol Scand, 101, pp. 381-383Salzer, J., Svenningsson, A., Sundström, P., Season of birth and multiple sclerosis in Sweden (2010) Acta Neurol Scand, 122, pp. 70-73Bayes, H.K., Weir, C.J., O'Leary, C., Timing of birth and risk of multiple sclerosis in the Scottish population (2010) Eur Neur, 63, pp. 36-40Saastamoinen, K.P., Auvinen, M.K., Tienari, P.J., Month of birth is associated with multiple sclerosis but not with HLA-DR15 in Finland (2012) Mult Scler, 18, pp. 563-568Fernandes de Abreu, D.A., Babron, M.C., Rebeix, I., Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosis (2009) Mult Scler, 15, pp. 1146-1152Willer, C.J., Dyment, D.A., Sadovnick, A.D., Timing of birth and risk of multiple sclerosis: Population based study (2005) BMJ, 330, p. 120. , Canadian Collaborative Study GroupDeussing, E.C., Jankosky, C.J., Clark, L.L., Estimated incidence of multiple sclerosis among United States Armed Forces personnel using the Defense Medical Surveillance System (2012) Mil Med, 177, pp. 594-600Staples, J., Ponsonby, A.L., Lim, L., Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: Longitudinal analysis (2010) BMJ, 340, p. 1640Givon, U., Zeilig, G., Dolev, M., The month of birth and the incidence of multiple sclerosis in the Israeli population (2012) Neuroepidemiology, 38, pp. 64-68Fragoso, Y.D., Shearer, K.D., Adoni, T., Month of birth does not seem to interfere with the development of multiple sclerosis later in life in Brazilian patients (2012) Neuroepidemiology, 39, pp. 70-71Koch, M., de Keyser, J., Tremlett, H., Timing of birth and disease progression in multiple sclerosis (2008) Mult Scler, 14, pp. 793-798Tremlett, H.L., Devonshire, V.A., Does the season or month of birth influence disease progression in multiple sclerosis? (2006) Neuroepidemiology, 26, pp. 195-198Poser, C.M., Paty, D.W., Scheinberg, L., New diagnostic criteria for multiple sclerosis: Guidelines for research protocols (1983) Ann Neurol, 13, pp. 227-231McDonald, W.I., Compston, A., Edan, G., Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis (2001) Ann Neurol, 50, pp. 121-127Polman, C.H., Reingold, S.C., Edan, G., Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria" (2005) Ann Neurol, 58, pp. 840-846Kurtzke, J.F., Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS) (1983) Neurology (Cleveland), 33, pp. 1444-1452Damasceno, A., von Glehn, F., de Deus-Silva, L., Monthly variation of multiple sclerosis activity in the Southern hemisphere: Analysis from 996 relapses in Brazil (2012) Eur J Neurol, 19, pp. 660-662Altmann, D.M., Review series on helminths, immune modulation and the hygiene hypothesis: Nematode coevolution with adaptive immunity, regulatory networks and the growth of inflammatory diseases (2009) Immunology, 126, pp. 1-2Correale, J., Farez, M.F., The impact of environmental infections (parasites) on MS activity (2011) Mult Scler, 17, pp. 1162-1169Watson, P.E., McDonald, B.W., Seasonal variation of nutrient intake in pregnancy: Effects on infant measures and possible influence on diseases related to season of birth (2007) Eur J Clin Nutr, 61, pp. 1271-1280Melcon, M., Melcon, C., Bartoloni, L., Towards establishing MS prevalence in Latin America and the Caribbean (2013) Mult Scler, 19, pp. 145-152. , The "Grupo Colaborativo Multicéntrico para el Estudio de la Esclerosis Multiple en America Latina y el Caribe" (GEEMAL)Taylor, B.V., Pearson, J.F., Clarke, G., MS prevalence in New Zealand, an ethnically and latitudinally diverse country (2010) Mult Scler, 16, pp. 1422-1431Dobson, R., Giovannoni, G., Ramagopalan, S., The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude (2013) J Neurol Neurosurg Psychiatry, 84, pp. 427-43

The extrapituitary prolactin promoter polymorphism is associated with rheumatoid arthritis and anti-CCP antibodies in Mexican population

Background and objective: Women with multiple sclerosis (MS) who intend to get pregnant are often advised to discontinue disease modifying therapy (DMT) prior to conception. This recommendation is not based on medical evidence and may interfere with disease control by immunomodulatory drugs. The present study was designed to help discuss the effect of DMT for MS on pregnancy and on disease course. Patients and methods: Retrospective data from 152 pregnancies of 132 women with MS were collected by the physician in charge of the case. All data were entered into a specific file for qualitative and quantitative statistical analysis. Results: From the total group of patients, 89 pregnancies occurred without any exposure to MS drugs, while 61 pregnancies occurred with at least eight weeks of exposure to MS immunomodulatory drugs. The rate of obstetric and neonatal complications was similar in both groups, except for the newborn weight and height which was smaller for mothers receiving medications. Mothers' post-delivery relapse rate and EDSS scores in the follow-up period were significantly higher in the absence of treatment. Conclusion: It is possible that, with further such supportive data, international guidelines on MS treatment in young women who intend to get pregnant may need to be revised. " 2012 Elsevier B.V.",,,,,,"10.1016/j.clineuro.2012.04.024",,,"http://hdl.handle.net/20.500.12104/45105","http://www.scopus.com/inward/record.url?eid=2-s2.0-84872295057&partnerID=40&md5=c20df0b7feedea45f4a1222a90afb6b2",,,,,,"2",,"Clinical Neurology and Neurosurgery",,"15

Month Of Birth Does Not Seem To Interfere With The Development Of Multiple Sclerosis Later In Life In Brazilian Patients

[No abstract available]3917071Givon, U., Zeilig, G., Dolev, M., Achiron, A., The month of birth and the incidence of multiple sclerosis in the Israeli population (2012) Neuroepidemiology, 38, pp. 64-68Templer, D.I., Trent, N.H., Spencer, D.A., Trent, A., Corgiat, M.D., Mortensen, P.B., Gordon, M., Season of birth in multiple sclerosis (1992) Acta Neurol Scand, 85, pp. 107-109Wiberg, M., Templer, D.I., Season of birth in multiple sclerosis in Sweden: Replication of Denmark findings (1994) J Orthomol Med, 9, pp. 71-74Bharanidharan, P., Monthly distribution of multiple sclerosis patients' births (1997) International Journal of Biometeorology, 40 (2), pp. 117-118Willer, C.J., Dyment, D.A., Sadovnick, A.D., Rothwell, P.M., Murray, C.J., Ebers, G.C., Timing of birth and risk of multiple sclerosis (2005) BMJ, 330, p. 120Staples, J., Ponsonby, A.L., Lim, L., Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: Longitudinal analysis (2010) BMJ, 340, pp. c1640Salzer, J., Svenningsson, A., Sundström, P., Season of birth and multiple sclerosis in Sweden (2010) Acta Neurol Scand, 122, pp. 70-73Bayes, H.K., Weir, C.J., O'Leary, C., Timing of birth and risk of multiple sclerosis in the Scottish population (2010) Eur Neur, 63, pp. 36-40Saastamoinen, K.P., Auvinen, M.K., Tienari, P.J., Month of birth is associated with multiple sclerosis but not with HLA-DR15 in Finland (2012) Mult Scler, 18, pp. 563-568Sadovnick, A.D., Yee, I.M.L., Season of birth in multiple sclerosis (1994) Acta Neurologica Scandinavica, 89 (3), pp. 190-19