Sigma Model Corrections to the Confining Background

Sigma model ($\alpha^{\prime}$) corrections to the confining string background are obtained. The main result is that the Poincar\'e invariant ansatz is maintained. Physical conditions for the dissapearance of the naked singularity are discussed.Comment: LaTeX,12 page

Nonlinear signaling on biological networks: the role of stochasticity and spectral clustering

Signal transduction within biological cells is governed by networks of interacting proteins. Communication between these proteins is mediated by signaling molecules which bind to receptors and induce stochastic transitions between different conformational states. Signaling is typically a cooperative process which requires the occurrence of multiple binding events so that reaction rates have a nonlinear dependence on the amount of signaling molecule. It is this nonlinearity that endows biological signaling networks with robust switch-like properties which are critical to their biological function. In this study, we investigate how the properties of these signaling systems depend on the network architecture. Our main result is that these nonlinear networks exhibit bistability where the network activity can switch between states that correspond to a low and high activity level. We show that this bistable regime emerges at a critical coupling strength that is determined by the spectral structure of the network. In particular, the set of nodes that correspond to large components of the leading eigenvector of the adjacency matrix determines the onset of bistability. Above this transition, the eigenvectors of the adjacency matrix determine a hierarchy of clusters, defined by its spectral properties, which are activated sequentially with increasing network activity. We argue further that the onset of bistability occurs either continuously or discontinuously depending upon whether the leading eigenvector is localized or delocalized. Finally, we show that at low network coupling stochastic transitions to the active branch are also driven by the set of nodes that contribute more strongly to the leading eigenvector.Comment: 30 pages, 12 figure

Noise rectification in quasigeostrophic forced turbulence

We study the appearance of large scale mean motion sustained by stochastic forcing on a rotating fluid (in the quasigeostrophic approximation) flowing over topography. As in other noise rectification phenomena, the effect requires nonlinearity and absence of detailed balance to occur. By application of an analytical coarse graining procedure we identify the physical mechanism producing such effect: It is a forcing coming from the small scales that manifests in a change in the effective viscosity operator and in the effective noise statistical properties.Comment: 4 pages revtex, including 5 figures. Related material at http://www.imedea.uib.es/Nonlinear and http://www.imedea.uib.es/Oceanography Figure 4 replaced by a slightly better on

Whose land of the free? Latina transgender immigrants in the United States

Transgender women from Latin America are driven to migrate to the United States in pursuit of a place where they can escape violence and discrimination. However, their experience in the United States continues to be one of oppression. Transgender Latina immigrants in the United States are the target of systematic oppression and interpersonal violence that affect their overall health and well-being. These experiences have led many transgender Latina immigrants to assume leadership roles and to organise social movements in demand for their human rights and dignity in the United States. Recommendations are provided for community leaders, policymakers, and academics