Kinematics of the opening of northern sector, Neuquén Basin

La cuenca Neuquina es una cuenca extensional de tras-arco productora de hidrocarburos, formada en el borde occidental del Gondwana y abierta al océano Pacífico a lo largo de su margen occidental. Su período extensional triásico tardío a jurásico temprano se caracteriza por la formación de una serie de depocentros aislados. Los depocentros más septentrionales son losde Yeguas Muertas - Nieves Negras, Atuel, Valenciana, Malargüe, Palauco y Cara Cura - Reyes. En este trabajo presentamos modelos de arquitectura de dichos depocentros obtenidos a partir de la integración de estudios geológicos previos con estudios estructurales y estratigráficos nuevos. El depocentro Atuel está caracterizado por dos hemigrábenes de rumbo nornoeste con distribución bimodal de fallas nor-noroeste y oeste-noroeste. Los estudios cinemáticos de fallas menores indican una dirección de extensión máxima nor-noreste a noreste, sugiriendo que el depocentro corresponde a un rift oblicuo. Los depocentros Malargüe y Cara Cura - Reyes presentan conjuntos heterogéneos de datos cinemáticos de fallas con un patrón bimodal en los ejes extensionales desarrollado durante un simple período de deformación extensional. En el trabajo evaluamos las posibles causas para esta heterogeneidad, tales como reactivación de anisotropías, deformación triaxial, múltiples eventos de deformación y perturbación local del campo de esfuerzos próximo a fallas mayores, y concluimos que estos depocentros fueron generados bajo un régimen de deformación triaxial. El análisis de movimiento de fallas nos permitió derivar información cinemática para cada depocentro, y a partir de ella inferimos interpretaciones dinámicas para la apertura de la cuenca. Nuestromodelo sugiere la existencia de una combinación de dos eventos tectónicos superpuestos: una dirección de extensión principal nor-noroeste producto de la fragmentación del supercontinente de Pangea, y otra dirección de extensión secundaria oeste-noroeste a oeste-este relacionada con la interacción de las placas Pacífica y Sudamericana.The Neuquén Basin is an oil-bearing back-arc extensional basin, formed in the western edge of the Gondwana continent and open to the Pacific at its western margin. Its extensional period, from Late Triassic to Early Jurassic, is characterized by the development of several isolated depocenters. The northernmost depocenters correspond to Yeguas Muertas - Nieves Negras, Atuel, Valenciana, Malargüe, Palauco and Cara Cura - Reyes. By integrating previous geological studies with new structural and stratigraphic studies we present models for the architecture of each depocenter. The extensional structure of the Atuel depocenter is characterized by two NNW-trending halfgrabens with bimodal distribution of normal faults inside -NNW and WNW. Kinematic studies of small-scale extensional faults show a NNE to NE maximum stretching direction (?1), suggesting that the Atuel depocenter acted as an oblique rift. The Malargüe and Cara Cura - Reyes depocenters present kinematically heterogeneous sets of fault-slip data with bimodal pattern of extension axes developed during a single period of extensional deformation. We evaluated possible causes for this heterogeneity, such as anisotropy reactivation, triaxial deformation, multiple deformation events, and local perturbation of stress field close to major faults, and concluded that these depocenters were opened under a triaxial strain field. Fault-slip data analyses allow us to derive kinematic information for each depocenter, and this is used to achieve dynamic interpretations for the opening of the basin. Our model suggests a combination of two tectonic events, regional NNE extension during the fragmentation of the Pangea supercontinent and NW to W-E extension related to the Pacific and South America plate interaction.Fil: Giambiagi, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla; ArgentinaFil: Tunik, Maisa Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación en Paleobiología y Geología; Argentina. Universidad Nacional del Comahue; ArgentinaFil: Barredo, Silva. Universidad de Buenos Aires; ArgentinaFil: Bechis, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla; ArgentinaFil: Ghiglione, Matias. Universidad de Buenos Aires; ArgentinaFil: Alvarez, Pamela. Enap-Sipetrol; ChileFil: Drosina, Marina. YPF - Tecnología; Argentin

Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations. Large scale structure is however from where drastic improvements should originate. In this paper, we explain the theoretical motivations for pursuing such measurements and the challenges that lie ahead. In particular, we discuss and identify theoretical targets regarding the measurement of primordial non-Gaussianity. We argue that when quantified in terms of the local (equilateral) template amplitude $f_{\rm NL}^{\rm loc}$ ($f_{\rm NL}^{\rm eq}$), natural target levels of sensitivity are $\Delta f_{\rm NL}^{\rm loc, eq.} \simeq 1$. We highlight that such levels are within reach of future surveys by measuring 2-, 3- and 4-point statistics of the galaxy spatial distribution. This paper summarizes a workshop held at CITA (University of Toronto) on October 23-24, 2014.Comment: 27 pages + reference

Mapping Cosmic Dawn and Reionization: Challenges and Synergies

Cosmic dawn and the Epoch of Reionization (EoR) are among the least explored observational eras in cosmology: a time at which the first galaxies and supermassive black holes formed and reionized the cold, neutral Universe of the post-recombination era. With current instruments, only a handful of the brightest galaxies and quasars from that time are detectable as individual objects, due to their extreme distances. Fortunately, a multitude of multi-wavelength intensity mapping measurements, ranging from the redshifted 21 cm background in the radio to the unresolved X-ray background, contain a plethora of synergistic information about this elusive era. The coming decade will likely see direct detections of inhomogenous reionization with CMB and 21 cm observations, and a slew of other probes covering overlapping areas and complementary physical processes will provide crucial additional information and cross-validation. To maximize scientific discovery and return on investment, coordinated survey planning and joint data analysis should be a high priority, closely coupled to computational models and theoretical predictions.Comment: 5 pages, 1 figure, submitted to the Astro2020 Decadal Survey Science White Paper cal

Cosmology with the Highly Redshifted 21cm Line

In addition to being a probe of Cosmic Dawn and Epoch of Reionization astrophysics, the 21cm line at $z>6$ is also a powerful way to constrain cosmology. Its power derives from several unique capabilities. First, the 21cm line is sensitive to energy injections into the intergalactic medium at high redshifts. It also increases the number of measurable modes compared to existing cosmological probes by orders of magnitude. Many of these modes are on smaller scales than are accessible via the CMB, and moreover have the advantage of being firmly in the linear regime (making them easy to model theoretically). Finally, the 21cm line provides access to redshifts prior to the formation of luminous objects. Together, these features of 21cm cosmology at $z>6$ provide multiple pathways toward precise cosmological constraints. These include the "marginalizing out" of astrophysical effects, the utilization of redshift space distortions, the breaking of CMB degeneracies, the identification of signatures of relative velocities between baryons and dark matter, and the discovery of unexpected signs of physics beyond the $\Lambda$CDM paradigm at high redshifts.Comment: Science white paper submitted to Decadal 2020 surve

Tumor associated fibroblast: impact on osteosarcoma primary and metastatic tumoral microenvironment and treatment response

Tumor associated fibroblast (TAF) have been implicated in almost every aspect of tumoral biology. Of relevance TAF could be modulating response to treatment and overall microenvironment development. Given that Osteosarcoma (OS) have the same 5-year survival rate for metastatic and treatment resistant patients since 1970 ́s, we dediced to investigate the role of TAF in OS primary and metastatic niches. Aim: Evaluate TAF and human OS cell lines interaction in primary and pulmonary metastatic environments. To analyze if metastatic OS cell line has a higher inducing power than non-metastatic OS cell line analyzing the expression of different ABC transporters im-plicated in chemoresistance and the ability to exclude doxorubicin and rhodamine. Methods: The expression of ABC transporters was analyzed by RT-qPCR on conditioned fibroblast. Rhodamine 123 exclution assay was used to determine the activity of P-glycoprotein (P-gp) mediated transport and doxorubicin (DOX) exclution was performed to analysis the overall ABC-related chemoresistant capacity. To evaluate the interaction of fibroblast with metastatic (LM7) and non-metastatic (SAOS2) OS human cells hetero – spheroid formation assays were performed. Results: LM7 conditioned medium (CM) induced an overall upregulation of ABC transporters in comparison with SAOS2 CM. Conditioned fibroblast with LM7 CM showed lower levels of intracellular DOX and Rhodomine in comparison with SAOS2 CM fibroblast. Mixed spheroid compose of fibroblast ans OS cell lines display a lower area and more compact than single type aggregates. OS has not changed the 5-year rate survival for metastatic patients since the 70’, so the need to understand aspects of OS metastatic biology and chemoresistance could be helpful to develop new treat-ments to this group. Knowing aspects of the associated stroma and in particular TAF, could allow the development of new therapeutic possibilities targeting the tumoral associated stroma.Fil: Valenzuela Alvarez, Matias Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Rizzo, Matias Eduardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Auzmendi, Jeronimo. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Lazarowski, Alberto. Universidad de Buenos Aires; ArgentinaFil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaLXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica: LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de NanomedicinasArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología Experimenta

Integridad ecológica de la cuenca del río Ramuschaca, distrito de Zurite, Anta, Cusco

Universidad Nacional Agraria La Molina. Escuela de Posgrado. Maestría en Gestión Integral de Cuencas HidrográficasEl presente trabajo de investigación se realizó en la cuenca del río Ramuschaca, ubicada en el distrito de Zurite, provincia de Anta, región Cusco el 2019; con el objetivo de evaluar de la integridad ecológica ribereña de la cuenca del río Ramuschaca, frente a actividades antrópicas que se realizan en el cauce del río. Se establecieron nueve puntos de evaluación, tres para cada zona de la cuenca (alta, media y baja); la metodología utilizada para determinar la integridad ecológica fue el análisis de componentes principales; para la calidad ecológica se utilizó el método ECOSTRIAND, que combina los valores del Índice Biótico Andino (ABI) utilizando las propuestas de Encalada et al. (2011) y Acosta et al. (2009) para la identificación de macroinvertebrados como indicadores de calidad y el Índice de Calidad de Vegetación de Ribera Andino (QBR-And) mediante parámetros de estructura, calidad y atributos de ribera; adicionalmente, se evaluó el Índice de Hábitat Fluvial (IHF) a través de parámetros de frecuencia, sustrato, velocidad, sombra, heterogeneidad y cobertura del cauce fluvial; y, la determinación de la calidad de agua (ICA), se estableció mediante parámetros fisicoquímicos y microbiológicos. Como resultados, se determinó la integridad ecológica de la cuenca del río Ramuschaca como “Buena”. La calidad ecológica, se estableció como “Buena”, en la cuenca alta (puntos 1, 2 y 3) y cuenca media (punto 4); “Regular”, en la cuenca media (punto 5); “Mala”, en la cuenca media (punto 6), cuenca baja (puntos 7 y 8); y “Pésima”, en la cuenca baja (punto 9). Para la evaluación del Índice de Hábitat Fluvial (IHF), se estableció un nivel de calidad “Muy buena”, en la cuenca alta (puntos 1, 2 y 3); “Buena”, en la cuenca media (puntos 4, 5 y 6) y cuenca media (punto 7); y, “No llega a buena”, para la cuenca baja (puntos 8 y 9). Con referencia a la calidad de agua, mediante parámetros fisicoquímicos y microbiológicos (ICA) se obtuvo calidad “Excelente”, para la cuenca alta (puntos 1, 2 y 3) y cuenca media (punto 4); calidad “Buena”, para la cuenca media (punto 5); “Regular”, para la cuenca media (punto 6); “Excelente”, para la cuenca baja (punto 7); y “Regular”, para la cuenca baja (puntos 8 y 9).The present research work was conducted in the Ramuschaca river basin, located in the district of Zurite, province of Anta, Cusco region in 2019; with the objective of evaluating the ecological integrity of the Ramuschaca river basin, against anthropogenic activities that are carried out in the riverbed. Nine evaluation points were established, three for each zone of the basin (high, medium and low); the methodology used to determine the ecological integrity was the principal component analysis; for the ecological quality, the ECOSTRIAND method was used, which combines the values of the Andean Biotic Index (ABI) using the proposals of Encalada et al. (2011) and Acosta et al. (2009) for the identification of macroinvertebrates as quality indicators and the Andean Riparian Vegetation Quality Index (QBR-And) through parameters of structure, quality and riparian attributes; additionally, the Fluvial Habitat Index (IHF) was evaluated through parameters of frequency, substrate, velocity, shade, heterogeneity and coverage of the river channel; and, the determination of water quality (ICA), was established through physicochemical and microbiological parameters. As a result, the ecological integrity of the Ramuschaca river basin was determined as "Good". The ecological quality was established as "Good" in the upper basin (points 1, 2 and 3) and middle basin (point 4); "Fair" in the middle basin (point 5); "Bad" in the middle basin (point 6), lower basin (points 7 and 8); and "Poor" in the lower basin (point 9). For the evaluation of the Fluvial Habitat Index (IHF), a quality level of "Very good" was established in the upper basin (points 1, 2 and 3); "Good" in the middle basin (points 4, 5 and 6) and middle basin (point 7); and "Not good" in the lower basin (points 8 and 9). With reference to water quality, by means of physicochemical and microbiological parameters (ICA), "Excellent" quality was obtained for the upper basin (points 1, 2 and 3) and middle basin (point 4); "Good" quality for the middle basin (point 5); "Fair" for the middle basin (point 6); "Excellent" for the lower basin (point 7); and "Fair" for the lower basin (points 8 and 9)

A Data-Driven Approach to Lean and Digital Process Re-Modeling for Sustainable Textile Production: A Case Study

This study presents a data-driven framework that integrates lean management and digital business process modelling to enhance sustainability in textile manufacturing. Conducted in a company producing industrial safety textiles from Peru, this research applies lean tools within a digital BPM structure supported by real-time data tracking. The integrated approach led to increased production efficiency (from 79% to 86%), reduced setup times, and improved operational agility. The digital infrastructure empowered operators and supported informed decision-making. This work contributes to Industrial Engineering, Business Administration, and MIS by offering a holistic model that bridges lean principles with Industry 4.0 technologies. The findings, though context-specific, provide actionable insights for manufacturers aiming for smart and sustainable operations. Future research should validate the proposed framework across diverse industrial contexts and assess its longitudinal impact on lean performance outcomes

Dynamic vaccination in partially overlapped multiplex network

In this work we propose and investigate a strategy of vaccination which we call "dynamic vaccination." In our model, susceptible people become aware that one or more of their contacts are infected and thereby get vaccinated with probability ω, before having physical contact with any infected patient. Then the nonvaccinated individuals will be infected with probability β. We apply the strategy to the susceptible-infected-recovered epidemic model in a multiplex network composed by two networks, where a fraction q of the nodes acts in both networks. We map this model of dynamic vaccination into bond percolation model and use the generating functions framework to predict theoretically the behavior of the relevant magnitudes of the system at the steady state. We find a perfect agreement between the solutions of the theoretical equations and the results of stochastic simulations. In addition, we find an interesting phase diagram in the plane β-ω, which is composed of an epidemic and a nonepidemic phase, separated by a critical threshold line βc, which depends on q. As q decreases, βc increases, i.e., as the overlap decreases, the system is more disconnected, and therefore more virulent diseases are needed to spread epidemics. Surprisingly, we find that, for all values of q, a region in the diagram where the vaccination is so efficient that, regardless of the virulence of the disease, it never becomes an epidemic. We compare our strategy with random immunization and find that, using the same amount of vaccines for both scenarios, we obtain that the spread of disease is much lower in the case of dynamic vaccination when compared to random immunization. Furthermore, we also compare our strategy with targeted immunization and we find that, depending on ω, dynamic vaccination will perform significantly better and in some cases will stop the disease before it becomes an epidemic.Fil: Alvarez Zuzek, Lucila Gisele. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Grupo de Investigación del Departamento de Química de la Unmdp | Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata. Grupo de Investigación del Departamento de Química de la Unmdp; ArgentinaFil: Di Muro, Matias Alberto. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Grupo de Investigación del Departamento de Química de la Unmdp | Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata. Grupo de Investigación del Departamento de Química de la Unmdp; ArgentinaFil: Havlin, S.. Bar-ilan University; IsraelFil: Braunstein, Lidia Adriana. Boston University; Estados Unido