Position estimation delays in signal injection-based sensorless PMSM drives

The causes of position estimation delays and their effects on the sensorless control of permanent magnet synchronous motor drives are investigated. The position of a permanent magnet synchronous machine is estimated via the injection of high frequency voltage signals. The delays under investigation are due to the digital implementation of the control algorithm and to the digital filters adopted for decoupling the inspection signals from the fundamental components of the stator current measures. If not correctly modeled and compensated, such delays can reduce the performance of the control scheme. Experimental results are provided, proving the accuracy of the modeling approach and the effectiveness of the related compensation strateg

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Direct inhibition of the pacemaker (I-f) current in rabbit sinoatrial node cells by genistein

1 Genistein is a tyrosine kinase inhibitor which interferes with the activity of several ionic channels either by altering modulatory phosphorylating processes or by direct binding. In whole-cell conditions, genistein induces a partial inhibition of the pacemaker (If) current recorded in cardiac sinoatrial and ventricular myocytes. 2 We investigated the mechanism of action of genistein (50 mM) on the If current in whole-cell, cellattached, and inside-out configurations, and the measured fractional inhibitions were similar: 26.6, 27.2, and 33.6%, respectively. 3 When ATP was removed from the whole-cell pipette solution no differences were revealed in the effect of the drug when compared to metabolically active cells. Genistein fully maintained its blocking ability even when herbimycin, a tyrosine kinase inhibitor, was added to the whole-cell ATP-free pipette solution. 4 Genistein-induced block was independent of the gating state of the channel and did not display voltage or current dependence; this independence distinguishes genistein from all other f-channel blockers. 5 When inside-out experiments were performed to test for a direct interaction with the channel, genistein, superfused on the intracellular side of the membrane, decreased the maximal If conductance, and slightly shifted the current\u2013activation curve to the left. Furthermore, the effect of genistein was independent of cAMP modulation. 6 We conclude that, in addition to its tyrosine kinase-inhibitory properties, genistein also blocks If by directly interacting with the channel, and thus cannot be considered a valuable pharmacological tool to investigate phosphorylation-dependent modulatory pathways of the If current and of cardiac rhythm

Data from docking simulations to develop an efficient strategy able to evaluate the interactions between RAGE and MDA-induced albumin adducts

This data article contains the results of docking simulations performed in order to develop a suitable in silico strategy able to assess the stability of the putative complexes between RAGE and MDA induced adducts on human albumin as experimentally determined doi: 10.1016/j.redox.2016.12.017, (Degani et al., 2017) [1]. The docking simulations involved different approaches to give a simplified yet realistic representation of the protein adducts and their environment. With increasing complexity, simulations involved the corresponding albumin tripeptides and pentapeptides with the modified residue in the central position as well as pseudo-structures which were generated by collecting the albumin residues around the adducted residue within a sphere of 7.5 \uc5 and 5 \uc5 radius. The reliability of the tested approaches was assessed by monitoring the score differences between adducted and unmodified residues. The obtained results revealed the greater predictive power of the spherical pseudo-structures compared to the simple tri- or pentapeptidic sequences thus suggesting that RAGE recognition involves residues which are spatially close to the modified residue even though not necessarily adjacent in the primary sequence

Odd and Even Lidstone-type polynomial sequences. Part 1: basic topics

Abstract Two new general classes of polynomial sequences called respectively odd and even Lidstone-type polynomials are considered. These classes include classic Lidstone polynomials of first and second kind. Some characterizations of the two classes are given, including matrix form, conjugate sequences, generating function, recurrence relations, and determinant forms. Some examples are presented and some applications are sketched