Oscillating Superfluidity of Bosons in Optical Lattices

We follow up on a recent suggestion by C. Orzel et. al., Science, 291, 2386 (2001), whereby bosons in an optical lattice would be subjected to a sudden parameter change from the Mott to the superfluid phase. We analyze the Bose Hubbard model with a modified coherent states path integral which can escribe - both - phases. The saddle point theory yields collective oscillations of the uniform superfluid order parameter. These would be seen in time resolved interference patterns made by the released gas. We calculate the collective oscillation's damping rate by phason pair emission. In two dimensions the overdamped region largely overlaps with the quantum critical region. Measurements of critical dynamics on the Mott side are proposed.Comment: 4 pages 1 eps figures; Final version as appears in PRL. Added discussion on spontaneous generation of vortice

Establishing trends in ATSIC regional council populations using census data: A cautionary note

Section 94(1) of the Aboriginal and Torres Strait Islander Act 1989 requires regional councils to 'formulate and revise from time to time a regional plan for improving the economic, social and cultural status of Aboriginal and Torres Strait Islander residents of the region'. Guidelines for the preparation of such regional plans require that councils compile a data base on the demographic composition of their council area and to consider how various social indicators may differ in the future, say in the next five years. While not explicitly stated, the guidelines thus require that some form of demographic trend analysis be undertaken for council areas so that meaningful projections of the population to be serviced may be calculated. This paper seeks to point out that limitations in official census data for Aborigines and Torres Strait Islanders draw into question the validity of trend analysis based on time series data for regional council areas. Accordingly, the meaningful application of projection techniques to estimate future population profiles using existing census data is severely restricted. Among the difficulties encountered in reconstructing council area populations are, census boundary changes over time, changes in enumeration techniques and coverage, the problems posed by self-identification and associated population growth, and, in some cases, the difficulty of matching ATSIC regional council boundaries with census geography. Following discussion of these problems, detailed figures showing changes in the size of the Aboriginal and Islander populations and labour force in each council area are presented using 1976 as the base year. As expected, geographic patterns of population and labour force change are difficult to discern and exact reasons for comparative growth or decline are impossible to determine. The paper concludes that reverse projections for regional council areas using 1991 Census data would provide a more reliable basis for establishing demographic trends. Although not entirely adequate, these reconstructions for ATSIC regional councils are the only estimates of these populations that have been undertaken to date

Employment implications of the growth of the Indigenous Australian working-age population to 2001

This paper has been specifically prepared as a submission to the review of the Aboriginal Employment Development Policy (AEDP) which is to be completed early in 1994. A critical innovative feature of the Commonwealth Government's AEDP, launched in 1986-87, is its overarching goal of attaining statistical employment equality between Indigenous and non-Indigenous Australians by the year 2000. This paper examines the nature of labour force planning and goal setting in the AEDP Statement. It then re-examines a critique of the statistical targets made by demographers Tesfaghiorghis and Gray in 1991. Using recently published 1991 Census data, the paper explores intercensal changes in the size and labour force status of the Indigenous population. The paper's main aim is to present new projections of the Indigenous population of working age to the year 2001 and to re-assess the employment creation goals that will need to be set if statistical equality is to be achieved. It is estimated that the Indigenous population of working age will exceed 200,000 by the year 2001 and that to achieve statistical equality between 6,400 and 7,400 new jobs per annum will need to be created. Both figures represent over 10 per cent of the 1991 base employment of Indigenous Australians and represent impossible targets. The paper highlights a number of statistical, methodological and conceptual issues. In particular, it emphasises that insufficient statistical data are available to make accurate projections and that a more sophisticated analytical framework is required. At the macro level, it will be essential to match the supply of Indigenous labour, in all its diversity, with regional demand. Given significant underestimation in initial AEDP goal-setting, the paper concludes that the aim of statistical equality may be both inappropriate and destined to fail and that a notion of equity that recognises diversity of both circumstances and aspirations is needed

Frustrated H-Induced Instability of Mo(110)

Using helium atom scattering Hulpke and L"udecke recently observed a giant phonon anomaly for the hydrogen covered W(110) and Mo(110) surfaces. An explanation which is able to account for this and other experiments is still lacking. Below we present density-functional theory calculations of the atomic and electronic structure of the clean and hydrogen-covered Mo(110) surfaces. For the full adsorbate monolayer the calculations provide evidence for a strong Fermi surface nesting instability. This explains the observed anomalies and resolves the apparent inconsistencies of different experiments.Comment: 4 pages, 2 figures, submitted to PR

Ferromagnetism in a hard-core boson model

The problem of ferromagnetism -- associated with a ground state with maximal total spin -- is discussed in the framework of a hard-core model, which forbids the occupancy at each site with more than one particle. It is shown that the emergence of ferromagnetism on finite square lattices crucially depends on the statistics of the particles. Fermions (electrons) lead to the well-known instabilities for finite hole densities, whereas for bosons (with spin) ferromagnetism appears to be stable for all hole densities.Comment: 8 pages, 7 figures, RevTex

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells

<p>Abstract</p> <p>Background</p> <p>A critical therapeutic challenge in epithelial ovarian carcinoma is the development of chemoresistance among tumor cells following exposure to first line chemotherapeutics. The molecular and genetic changes that drive the development of chemoresistance are unknown, and this lack of mechanistic insight is a major obstacle in preventing and predicting the occurrence of refractory disease. We have recently shown that Regulators of G-protein Signaling (RGS) proteins negatively regulate signaling by lysophosphatidic acid (LPA), a growth factor elevated in malignant ascites fluid that triggers oncogenic growth and survival signaling in ovarian cancer cells. The goal of this study was to determine the role of RGS protein expression in ovarian cancer chemoresistance.</p> <p>Results</p> <p>In this study, we find that RGS2, RGS5, RGS10 and RGS17 transcripts are expressed at significantly lower levels in cells resistant to chemotherapy compared with parental, chemo-sensitive cells in gene expression datasets of multiple models of chemoresistance. Further, exposure of SKOV-3 cells to cytotoxic chemotherapy causes acute, persistent downregulation of RGS10 and RGS17 transcript expression. Direct inhibition of RGS10 or RGS17 expression using siRNA knock-down significantly reduces chemotherapy-induced cell toxicity. The effects of cisplatin, vincristine, and docetaxel are inhibited following RGS10 and RGS17 knock-down in cell viability assays and phosphatidyl serine externalization assays in SKOV-3 cells and MDR-HeyA8 cells. We further show that AKT activation is higher following RGS10 knock-down and RGS 10 and RGS17 overexpression blocked LPA mediated activation of AKT, suggesting that RGS proteins may blunt AKT survival pathways.</p> <p>Conclusions</p> <p>Taken together, our data suggest that chemotherapy exposure triggers loss of RGS10 and RGS17 expression in ovarian cancer cells, and that loss of expression contributes to the development of chemoresistance, possibly through amplification of endogenous AKT signals. Our results establish RGS10 and RGS17 as novel regulators of cell survival and chemoresistance in ovarian cancer cells and suggest that their reduced expression may be diagnostic of chemoresistance.</p

Biomarkers of cardiovascular risk across phenotypes of osteoarthritis

Abstract: Background: The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to compare the levels of arterial CVD risk markers between OA phenotypes and controls. Method: The “Musculoskeletal pain in Ullensaker” Study (MUST) invited residents of Ullensaker municipality with self-reported OA to a medical examination. OA was defined according to the American College of Rheumatology (ACR) criteria and phenotyped based on joint distribution. Joints of the hands, hips and knees were examined by ultrasonography and conventional radiography, and scored for osteosteophytes. Hands were also scored for inflammation by grey scale (GS) synovitis and power Doppler (PD) signal. Control populations were a cohort of inhabitants of Oslo (OCP), and for external validation, a UK community-based register (UKPC). Pulse pressure augmentation index (AIx) and pulse wave velocity (PWV) were measured using the Sphygmocor apparatus (Atcor®). Ankel-brachial index (ABI) was estimated in a subset of patients. In separate adjusted regression models we explored the associations between ultrasonography and radiograph joint scores and AIx, PWV and ABI. CVD risk markers were also compared between phenotypes of OA and controls in adjusted analyses. Results: Three hundred and sixty six persons with OA were included (mean age (range); 63.0 (42.0–75.0)), (females (%); 264 (72)). Of these, 155 (42.3%) had isolated hand OA, 111 (30.3%) had isolated lower limb OA and 100 (27.3%) had generalized OA. 108 persons were included in the OCP and 963 persons in the UKPC; (mean age (range); OCP: 57.2 (40.4–70.4), UKPC: 63.9 (40.0–75.0), females (%); OCP: 47 (43.5), UKPC: 543 (56.4%). Hand osteophytes were associated with AIx while GS and PD scores were not related to CVD risk markers. All OA phenotypes had higher levels of AIx compared to OCP in adjusted analyses. External validation against UKPC confirmed these findings. Conclusions: Hand osteophytes might be related to higher risk of CVD. People with OA had higher augmented central pressure compared to controls. Words 330

SO(4) Theory of Competition between Triplet Superconductivity and Antiferromagnetism in Bechgaard Salts

Motivated by recent experiments with Bechgaard salts, we investigate the competition between antiferromagnetism and triplet superconductivity in quasi one-dimensional electron systems. We unify the two orders in an SO(4) symmetric framework, and demonstrate the existence of such symmetry in one-dimensional Luttinger liquids. SO(4) symmetry, which strongly constrains the phase diagram, can explain coexistence regions between antiferromagnetic, superconducting, and normal phases, as observed in (TMTSF)$_2$PF$_6$. We predict a sharp neutron scattering resonance in superconducting samples.Comment: 5 pages, 3 figures; Added discussion of applicability of SO(4) symmetry for strongly anisotropic Fermi liquids; Added reference

Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials

Background: Physiotherapy has long been a routine component of patient rehabilitation following hip joint replacement. The purpose of this systematic review was to evaluate the effectiveness of physiotherapy exercise after discharge from hospital on function, walking, range of motion, quality of life and muscle strength, for osteoarthritic patients following elective primary total hip arthroplasty. Methods: Design: Systematic review, using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions and the Quorom Statement. Database searches: AMED, CINAHL, EMBASE, KingsFund, MEDLINE, Cochrane library (Cochrane reviews, Cochrane Central Register of Controlled Trials, DARE), PEDro, The Department of Health National Research Register. Handsearches: Physiotherapy, Physical Therapy, Journal of Bone and Joint Surgery (Britain) Conference Proceedings. No language restrictions were applied. Selection: Trials comparing physiotherapy exercise versus usual/standard care, or comparing two types of relevant exercise physiotherapy, following discharge from hospital after elective primary total hip replacement for osteoarthritis were reviewed. Outcomes: Functional activities of daily living, walking, quality of life, muscle strength and range of hip joint motion. Trial quality was extensively evaluated. Narrative synthesis plus meta-analytic summaries were performed to summarise the data. Results: 8 trials were identified. Trial quality was mixed. Generally poor trial quality, quantity and diversity prevented explanatory meta-analyses. The results were synthesised and meta-analytic summaries were used where possible to provide a formal summary of results. Results indicate that physiotherapy exercise after discharge following total hip replacement has the potential to benefit patients. Conclusion: Insufficient evidence exists to establish the effectiveness of physiotherapy exercise following primary hip replacement for osteoarthritis. Further well designed trials are required to determine the value of post discharge exercise following this increasingly common surgical procedure