Meat Juice serology underestimates prevalence of Salmonella in pig herds

Salmonella serology is used for classifying pig herds in risk categories in several national quality programs. Meat juice is used as test matrix in most of these programs. Two studies were done to compare the salmonella ELISA test results from meat juice with blood serum as a reference. Pig blood and meat samples for these studies were collected in one slaughterhouse. ELISA tests were done with a commonly applied commercial test. In the first study paired blood serum and meat juice samples from 182 pigs were collected and tested in two different laboratories. In the second study meat and blood samples were collected from 470 herds, over 20.000 samples for each matrix

Dose-response relationship of fibrous dusts in intraperitoneal studies.

The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses

Pion photoproduction on the nucleon in the quark model

We present a detailed quark-model study of pion photoproduction within the effective Lagrangian approach. Cross sections and single-polarization observables are investigated for the four charge channels, $\gamma p\to \pi^+ n$, $\gamma n\to \pi^- p$, $\gamma p\to \pi^0 p$, and $\gamma n\to \pi^0 n$. Leaving the $\pi N\Delta$ coupling strength to be a free parameter, we obtain a reasonably consistent description of these four channels from threshold to the first resonance region. Within this effective Lagrangian approach, strongly constrainted by the quark model, we consider the issue of double-counting which may occur if additional {\it t}-channel contributions are included.Comment: Revtex, 35 pages, 16 eps figures; version to appear on PR

Photon Structure and Quantum Fluctuation

Photon structure derives from quantum fluctuation in quantum field theory to fermion and anti-fermion, and has been an experimentally established feature of electrodynamics since the discovery of the positron. In hadronic physics, the observation of factorisable photon structure is similarly a fundamental test of the quantum field theory Quantum Chromodynamics (QCD). An overview of measurements of hadronic photon structure in e+e- and ep interactions is presented, and comparison made with theoretical expectation, drawing on the essential features of photon fluctuation into quark and anti-quark in QCD.Comment: 29 pages, 15 figures, to appear in Philosophical Transactions of the Royal Society of London (Series A: Mathematical, Physical and Engineering Sciences

Effects of Surface Coatings on the Joint Formation During Magnetic Pulse Welding in Tube-to-Cylinder Configuration

Magnetic Pulse Welding (MPW) is a joining technique favorable for the generation of strong atomic bonded areas between different metals, e.g. aluminum and steel. Brittle intermetallic phases can be avoided due to the high-speed collision and the absence of external heat. The demand for the use of this technique in industries like automotive and plant engineering rises. However, workpieces used in these fields are often coated, e.g. in order to improve the corrosion resistance. Since the weld quality depends on the material’s behavior at the collision zone, surface layers in that region have to be taken into account as well. This work investigates the influences of different coating types. Aluminum to steel welding is used as an example system. On the inner steel part (C45) coatings like zinc, nickel and chrome are applied, while the aluminum flyer tubes (EN AW-6060) are anodized, chromated and passivated. Welding tests are performed using two different welding systems with varying discharging frequencies and four geometrical part setups. For all combinations, the flyer velocity during the process is measured by Photon Doppler Velocimetry (PDV). By using the uncoated material combination as a reference, the removal of surface layers due to jetting is analyzed. Finally, the weld quality is characterized in peel tests, shear-push tests and by the help of metallographic analysis. It is found that certain coatings improve the joint formation, while others are obstructive for the performance of MPW. Some coatings have no influence on the joining process at all

Experiences with a risk based meat inspection standard in pigs

The European Union legislation provides several possibilities to modernize meat inspection. Improvement of food safety by active contribution of food business operators in the supply chain being responsible for food safety is envisaged in these new standards

Influence of Axial Workpiece Positioning during Magnetic Pulse Welding of Aluminum-Steel Joints

Magnetic Pulse Welding (MPW) offers a method to economically join similar and dissimilar metals without the need for external physical or chemical binders, while avoiding the adverse heating effects seen in many welding techniques. MPW allows for the fabrication of joints via the harnessing of Lorentz forces, which result from discharging a current pulse through a coil. In the process an outer piece (flyer) is accelerated onto an inner piece (parent), and welding is achieved using propagating impact fronts. There are several geometrical factors to be considered including the flyer-coil distance, the parentflyer distance, as well as the axial relationship between flyer and coil (working length). Various shapes of the front are possible and each configuration has its own advantages and drawbacks. The goal of this work is to show not only how the aforementioned parameters are related, but also ways to optimize front propagations, which are vital to the welding result. This is done primarily by determining the influence of the working length of tubular MPW specimens. It is shown that for steel-aluminum joints in the given arrangements, three different front regimes exist, which are related to geometrical factors. These results are especially useful to avoid seemingly favorable but nevertheless suboptimal conditions for flyer movement that would reduce weld quality and energy efficiency of the process

An SU(3) model for octet baryon and meson fragmentation

The production of the octet of baryons and mesons in e^+ e^- collisions is analysed, based on considerations of SU(3) symmetry and a simple model for SU(3) symmetry breaking in fragmentation functions. All fragmentation functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member of the baryon octet (and similarly for fragmentation into members of the meson octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x, Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3) breaking parameter, \lambda, the model is successful in describing hadroproduction data at the Z pole. The fragmentation functions are then evolved using leading order evolution equations and good fits to currently available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file

Targeting tachykinin receptors in neuroblastoma

Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%. Adding targeted drugs to first-line therapy regimens is a promising approach to improve survival in these patients. TACR1 activation by substance P has been reported to be mitogenic in cancer cell lines. Tachykinin receptor (TACR1) antagonists are approved for clinical use as an antiemetic remedy since 2003. Tachykinin receptor inhibition has recently been shown to effectively reduce growth of several tumor types. Here, we report that neuroblastoma cell lines express TACR1, and that targeting TACR1 activity significantly reduced cell viability and induced apoptosis in neuroblastoma cell lines. Gene expression profiling revealed that TACR1 inhibition repressed E2F2 and induced TP53 signaling. Treating mice harboring established neuroblastoma xenograft tumors with Aprepitant also significantly reduced tumor burden. Thus, we provide evidence that the targeted inhibition of tachykinin receptor signaling shows therapeutic efficacy in preclinical models for high-risk neuroblastoma

Leading particle effect, inelasticity and the connection between average multiplicities in {\bf e+e−e^+e^-} and {\bf pppp} processes

The Regge-Mueller formalism is used to describe the inclusive spectrum of the proton in $p p$ collisions. From such a description the energy dependences of both average inelasticity and leading proton multiplicity are calculated. These quantities are then used to establish the connection between the average charged particle multiplicities measured in {\bf $e^+e^-$} and {\bf $pp/{\bar p}p$} processes. The description obtained for the leading proton cross section implies that Feynman scaling is strongly violated only at the extreme values of $x_F$, that is at the central region ($x_F \approx 0$) and at the diffraction region ($x_F \approx 1$), while it is approximately observed in the intermediate region of the spectrum.Comment: 20 pages, 10 figures, to be published in Physical Review