Symmetric Spaces and Fixed Points of Generalized Contractions

Some fixed point results in semi-metric spaces as well as in symmetric spaces are proved. Applications of our results to probabilistic spaces are also presented

Symmetric Spaces and Fixed Points of Generalized Contractions

Some fixed point results in semi-metric spaces as well as in symmetric spaces are proved. Applications of our results to probabilistic spaces are also presented

Doubt m-Polar Fuzzy Sets Based on BCK-Algebras

Doubt m-polar subalgebras (ideals) were introduced and some properties were investigated. Also, doubt m-polar positive implicative (commutative) ideals were defined and related results were proved

Semi-metric spaces and fixed points of α - φ -contractive maps

A negative answer to an open problem is provided. Fixed point results for α -φ -contractive mappings in semi-metric spaces are proved. To show the generality of this results, examples are given. Finally, an application of this result to probabilistic spaces is derived

Recent Progress in Lipid Nanoparticles for Cancer Theranostics: Opportunity and Challenges

Cancer is one of the major leading causes of mortality in the world. The implication of nanotherapeutics in cancer has garnered splendid attention owing to their capability to efficiently address various difficulties associated with conventional drug delivery systems such as non-specific biodistribution, poor efficacy, and the possibility of occurrence of multi-drug resistance. Amongst a plethora of nanocarriers for drugs, this review emphasized lipidic nanocarrier systems for delivering anticancer therapeutics because of their biocompatibility, safety, high drug loading and capability to simultaneously carrying imaging agent and ligands as well. Furthermore, to date, the lack of interaction between diagnosis and treatment has hampered the efforts of the nanotherapeutic approach alone to deal with cancer effectively. Therefore, a novel paradigm with concomitant imaging (with contrasting agents), targeting (with biomarkers), and anticancer agent being delivered in one lipidic nanocarrier system (as cancer theranostics) seems to be very promising in overcoming various hurdles in effective cancer treatment. The major obstacles that are supposed to be addressed by employing lipidic theranostic nanomedicine include nanomedicine reach to tumor cells, drug internalization in cancer cells for therapeutic intervention, off-site drug distribution, and uptake via the host immune system. A comprehensive account of recent research updates in the field of lipidic nanocarrier loaded with therapeutic and diagnostic agents is covered in the present article. Nevertheless, there are notable hurdles in the clinical translation of the lipidic theranostic nanomedicines, which are also highlighted in the present review along with plausible countermeasures.Peer reviewedFinal Published versio

Emerging Anthelmintic Resistance in Poultry: Can ethnopharmacological approaches offer a solution?

Limited pharmacological studies have been conducted on plant species used against poultry helminths. The objective of this study was to provide a basis for plant based anthelmintics as possible alternatives against poultry anthelmintic resistance. The study justified the need for alternative anthelmintics. The study places emphasis on the increasing anthelmintic resistance, mechanism of resistance, and preparational protocols for plant anthelmintics and their associated mechanism of action. Pharmaceutical studies on plants as alternative therapies for the control of helminth parasites have not been fully explored especially in several developing countries. Plants from a broad range of species produce a wide variety of compounds that are potential anthelmintics candidates. Important phenolic acids have been found in Brassica rapa L. and Terminalia avicenniodes Guill. and Perri that affect the cell signaling pathways and gene expression. Benzo (c) phenanthridine and isoquinoline alkaloids are neurotoxic to helminths. Steroidal saponins (polyphyllin D and dioscin) interact with helminthic mitochondrial activity, alter cell membrane permeability, vacuolation and membrane damage. Benzyl isothiocyanate glucosinolates interfere with DNA replication and protein expression, while isoflavones from Acacia oxyphylla cause helminth flaccid paralysis, inhibit energy generation, and affect calcium utilization. Condensed tannins have been shown to cause the death of nematodes and paralysis leading to expulsion from the gastro-intestinal tract. Flavonoids from Chenopodium album L and Mangifera indica L act through the action of phosphodiesterase and Ca(2+)-ATPase, and flavonoids and tannins have been shown to act synergistically and are complementary to praziquantel. Artemisinins from Artemisia cina O. Berg are known to disrupt mitochondrial ATP production. Terpenoids from Cucurbita moschata L disrupt neurotransmission leading to paralysis as well as disruption of egg hatching. Yeast particle encapsulated terpenes are effective for the control of albendazole-resistant helminths

Clinical Correlation Between Back Pain and Osteoarthritis Among Adults: A Cross-Sectional Study

Objective: To investigate the clinical correlation between back pain and the role of osteoarthritis in the etiology of this pain. Methods: This research employs a cross-sectional study design to investigate the clinical correlation between back pain and osteoarthritis in adults. Cross-sectional studies provide a snapshot of data at a specific time, making them suitable for assessing the prevalence and potential associations between variables of interest. Results: The study included 1106 participants. The most frequent age among them was 40-50 years (n= 486, 43.9%), followed by 18-28 years (n= 340, 30.7%). The most frequent gender among study participants was female (n= 560, 50.6%) followed by male (n= 546, 49.4%). The most frequent marital status among study participants was married (n= 702, 63.5%), followed by single (n= 353, 31.9%). The most frequent job among study participants was a government job (n= 480, 43.4%), followed by a private sector job (n= 177, 16%). Duration of suffering from back pain among study participants with most of them being 1 to 5 years (n= 505, 45.7%), followed by nothing (n= 373, 33.7%), and the least was 23 years and above (n= 13, 1.2%). Participants were asked about evaluating the impact of back pain on life. For personal care, the most frequent was (currently, I do not feel any pain) (n= 514, 46.5%). The severity of pain, the most frequent, was (I can usually take care of myself and do my own things without adding to my pain) (n= 923, 83.5%). The lift and move things, the most frequent was (I can lift heavy objects without it adding to my pain) (n= 524, 47.4%). The walking, the most frequent was (The pain does not prevent me from walking any distance) (n= 801, 72.4%). The Sitting, the most frequent was (I can sit in any chair for as long as I want) (n= 661, 59.8%). The stand-up, most frequent was (I can stay standing as long as I want without increasing my pain) (n= 523, 47.3%). For sleep, the most frequent answer was (My sleep is never disturbed by pain) (n= 611, 55.2%). The Social-life, most frequent was (My social life is normal and does not cause me more pain) (n= 860, 77.8%). Conclusion: The results of the study showed that most of the participants were married and taught in government jobs. The majority of them do not suffer from severe back pain that affects their lives. In addition, most of the study participants had good and effective communicatio

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has provided crucial protection against SARS-CoV-2. Neutralising antibody (nAb) responses are a key correlate of protection, and therefore measuring nAb responses is essential for monitoring vaccine efficacy. Fingerstick dried blood spots (DBS) are ideal for use in large-scale sero-surveillance because they are inexpensive, offer the option of self-collection and can be transported and stored at ambient temperatures. Such advantages also make DBS appealing to use in resource-limited settings and in potential future pandemics. In this study, nAb responses in sera, venous blood and fingerstick blood stored on filter paper were measured. Samples were collected from SARS-CoV-2 acutely infected individuals, SARS-CoV-2 convalescent individuals and SARS-CoV-2 vaccinated individuals. Good agreement was observed between the nAb responses measured in eluted DBS and paired sera. Stability of nAb responses was also observed in sera stored on filter paper at room temperature for 28 days. Overall, this study provides support for the use of filter paper as a viable sample collection method to study nAb responses.</p

Study of ordered hadron chains with the ATLAS detector

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