The potential impacts of digital transformation on organizations

Digital Transformation is the new trend in all industries. Although, the term’s usage in the industries is still vague and ambiguous, many organizations have claimed that they have begun their digital transformation journey or have a plan to do so. For those reasons there is an urgent necessity to understand what digital transformation is? and how to evaluate its impact on an organization. Thus, this paper seeks to investigate the potential impact of digital transformation on organizations. This study utilized a qualitative research method of investigation, semi-structured interviews with different participants from different organizations were performed. Two major areas were identified to be the most susceptible organizations’ functional areas that impacted by the transformation, and they synthesized into a cohesive model. The model includes Organization Business Processes Optimization, Organizational Information Technology which led to organization innovation. The model can help organizations to identify and consider the impact digital transformation

Intraventricular Hemorrhage in Preterm Infants, Review Article

Intraventricular hemorrhage (IVH) or germinal matrix (GM) in other words, is a condition that can occur in premature births and can lead to long-term medical and developmental effects. While GM/IVH can happen in full-term infants, the hemorrhage in this group of infants is different from periventricular hemorrhage (PVH)/IVH in premature infants. Family members and caregivers of preterm infants and those at risk of preterm birth are confronted with two significant uncertainties concerning these newborns: Is the survival of this child likely? Will the child experience long-term sequelae, particularly developmental sequelae, if they survive? The significance of these questions lies in their potential to impact future medical decisions, including the level of intensity in the care provided. Infants born prematurely can suffer from various acquired lesions in the central nervous system (CNS), leading to long-term disability. These lesions include GM/IVH, periventricular white matter injury, hemorrhage, and diffuse injury to the developing brain. GM/IVH continues to be a major contributor to both illness and death in premature newborns.  GM/IVH is primarily diagnosed by brain imaging techniques, typically cranial ultrasonography, as depicted below. Screening and serial examinations are essential for diagnosing GM/IVH, as it can occur without any noticeable clinical indications

The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

BACKGROUND: The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-based recommendations for the management of COVID-19 in the intensive care unit (ICU). METHODS: The SCCS COVID-19 panel included 51 experts with expertise in critical care, respirology, infectious disease, epidemiology, emergency medicine, clinical pharmacy, nursing, respiratory therapy, methodology, and health policy. All members completed an electronic conflict of interest disclosure form. The panel addressed 9 questions that are related to the therapy of COVID-19 in the ICU. We identified relevant systematic reviews and clinical trials, then used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach as well as the evidence-to-decision framework (EtD) to assess the quality of evidence and generate recommendations. RESULTS: The SCCS COVID-19 panel issued 12 recommendations on pharmacotherapeutic interventions (immunomodulators, antiviral agents, and anticoagulants) for severe and critical COVID-19, of which 3 were strong recommendations and 9 were weak recommendations. CONCLUSION: The SCCS COVID-19 panel used the GRADE approach to formulate recommendations on therapy for COVID-19 in the ICU. The EtD framework allows adaptation of these recommendations in different contexts. The SCCS guideline committee will update recommendations as new evidence becomes available

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Managing digital transformation in a global environment: The role of national culture

In today's fast-changing business environment, digital transformation has become an essential strategic imperative for companies seeking to maintain a competitive edge. However, research on the effect of national culture on digital transformation is lacking. This study seeks to address this gap by investigating the effect of national culture on digital transformation, with a focus on the mediating role of digital competencies and information system management practices, as well as the moderating effect of leadership. 250 managers and employees with digital transformation experience across various industries in Saudi Arabia were surveyed. Structural equation modeling (SEM) was employed to analyze and test the research hypotheses. The findings demonstrate that national culture significantly affects digital transformation, with digital competencies and information system management practices acting as mediators. Furthermore, the study discovered that leadership plays a moderating role in the relationship between national culture and digital transformation. The positive impact of national culture on digital transformation is amplified when there is a transformational leadership style in place. These insights hold significant implications for organizations embarking on digital transformation initiatives, emphasizing the importance of fostering a culture encourages digital innovation and risk-taking, investing in digital capabilities and effective information system management, and nurturing transformational leadership to drive successful digital transformation efforts

Green Innovation and Its Effects on Innovation Climate and Environmental Sustainability: The Moderating Influence of Green Abilities and Strategies

This research aims to explore the relationship among environmental sustainability, work environment, green innovation, and industrial companies’ innovation climate. The purpose of this exploration was to find out the explanation of how these variables influence each other and how they play a role in organizations sustainability. The study collected data from 253 employees in the Kingdom of Saudi Arabia’s oil and gas, minerals, and mining sectors. It employed the Warps analysis method to assess the relationships between green innovation, innovation climate, and environmental sustainability. By applying well-established theoretical frameworks, including the Innovation Diffusion Theory and Environmental Sustainability Theory, the research aims to provide a comprehensive understanding of the dynamics at play. The findings affirm the significant and positive relationships between green innovation and both environmental sustainability and the innovation climate within industrial firms. Moreover, the study highlights the mediating role of the innovation climate, which serves as a bridge connecting green innovation with environmental sustainability outcomes. Additionally, green motivational strategies and green abilities were identified as moderators that enhance the effectiveness of green innovation practices. This research carries practical and theoretical implications. It provides valuable insights for industrial firms seeking to integrate sustainability practices into their operations, enhance their innovation climate, and optimize their green innovation initiatives. The findings bridge the gap between theory and practice, guiding managerial decision-making and facilitating the implementation of sustainable practices. Moreover, the study enriches the theoretical foundations of sustainability and innovation by applying established theories to the industrial context, contributing to a more holistic understanding of these critical concepts in the modern business landscape

The Rapidly Changing Patterns in Bacterial Co-Infections Reveal Peaks in Limited Gram Negatives during COVID-19 and Their Sharp Drop Post-Vaccination, Implying Potential Evolution of Co-Protection during Vaccine–Virus–Bacterial Interplay

SARS-CoV-2 has caused the most devastating pandemic of all time in recent human history. However, there is a serious paucity of high-quality data on aggravating factors and mechanisms of co-infection. This study aimed to identify the trending patterns of bacterial co-infections and types and associated outcomes in three phases of the pandemic. Using quality hospital data, we have investigated the SARS-CoV-2 fatality rates, profiles, and types of bacterial co-infections before, during, and after COVID-19 vaccination. Out of 389 isolates used in different aspects, 298 were examined before and during the pandemic (n = 149 before, n = 149 during). In this group, death rates were 32% during compared to only 7.4% before the pandemic with significant association (p-value = 0.000000075). However, the death rate was 34% in co-infected (n = 170) compared to non-co-infected patients (n = 128), indicating a highly significant value (p-value = 0.00000000000088). However, analysis of patients without other serious respiratory problems (n = 28) indicated that among the remaining 270 patients, death occurred in 30% of co-infected patients (n = 150) and only 0.8% of non-co-infected (n = 120) with a high significant p-value = 0.00000000076. The trending patterns of co-infections before, during, and after vaccination showed a significant decline in Staphylococcus aureus with concomitant peaks in Gram negatives n = 149 before/n = 149 during, including Klebsiella pneumonian = 11/49 before/during, E. coli n = 10/24, A. baumannii n = 8/25, Ps. aeruginosa n = 5/16, and S. aureus 13/1. Nevertheless, in the post-vaccination phase (n = 91), gender-specific co-infections were examined for potential differences in susceptibility. Methicillin-resistant S. aureus dominated both genders followed by E. coli in males and females, with the latter gender showing higher rates of isolations in both species. Klebsiella pneumoniae declined to third place in male patients. The drastic decline in K. pneumoniae and Gram negatives post-vaccination strongly implied a potential co-protection in vaccines. Future analysis would gain more insights into molecular mimicry

Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF-α Signaling Pathways

Aim: A monoterpene and bioactive component of the plant Rhodiola rosea (R. rosea), rosiridin has beneficial effects on the human central nervous system and enhances brain function. The goal of this scientific study was to determine if rosiridin might shield rats from neurocognitive problems induced by scopolamine. Methods: To track the potential toxicities in rats, the acute toxicity in rats was clarified. Rosiridin at a dose of 10 mg/kg was tested in rats for 14 days. At the conclusion of the investigation, behavioral parameters that were used to identify the rats’ cognitive and motor abilities were evaluated. Several biochemical parameters were estimated using the prepared homogenate, including acetylcholine esterase (AChE), choline acetyltransferase (ChAT), radical scavengers produced by the body (Catalase-CAT, superoxide dismutase-SOD, and reduced glutathione-GSH), indicators of oxidative and nitrative burnout, pro-inflammatory (Interleukins- IL-1β, IL-6, interferon gamma IFN-ꝩ, and tumor necrosis factor-TNF-α), and cell apoptosis caspases 3 and 9. Results and Conclusion: A significant behavioral parameter restoration was seen in the rosiridin-treated group, including reduction in latency time during acquisition and retention trial in the Morris water maze test, and percentage of spontaneous alterations in the y-maze test, when compared to the disease control group that received scopolamine; rosiridin also altered the oxidative stress and neuroinflammatory markers, as well as restoring Ach and ChAT activities and normalizing GSH, SOD, MDA, TNF-α, nitrate, IL-1β, IL-6, IFN-ꝩ, caspases 3 and 9 levels. The results imply that rosiridin limits the effect of scopolamine on rat cognitive function

Investigating the Role of Temperature in Laser Assisted Chemical Bath Deposition for ZnO Growth for Photodetector Application

ZnO microrods (ZnO-MRs) have unique properties that make them highly attractive for applications such as optoelectronics, electronics, and sensors. This work demonstrates the successful synthesis of high-quality ZnO-MRs using a laser-assisted chemical bath deposition method. The optimal growth temperature for high-quality ZnO-MRs was found to be 61.10 °C, considerably lower than that required for conventional chemical methods. Various characterization techniques, including X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy Dispersive X-ray (EDX), and UV-Vis spectrometry, confirmed the structural and optical properties of the synthesized ZnO-MRs. The UV detection potentialities of the fabricated ZnO-MRs were investigated. All samples exhibited good UV detection capabilities with the sample grown at 61.10 °C showing the best performance with fast response and recovery times of 1.260 s and 1.398 s, respectively. These findings hold immense potential for developing more efficient methods for synthesizing ZnO-MRs for use in various applications