Determination of sulfamethoxazole in pharmaceutical formulations by flow injection system/HPLC with potentiometric detection using polypyrrole electrode

In this work, it was used a polypyrrole (PPy) electrode as a potentiometric electrochemical detector in a flow injection system in order to determine sulfamethoxazole in pharmaceutical formulations. The PPy electrode was prepared by cyclic voltammetry in acetonitrile solution. A linear relationship was observed over the concentration range of 2.5 × 10-5-1.25 × 10-3 mol L-1 with a correlation coefficient of 0.9977 and limit of detection (LOD) of 1.03 × 10-6 mol L-1 (S/N = 3). The recoveries in tablet and syrup formulations were found as 97.4 and 90.8% with the relative standard deviations of 0.62 and 1.04%, respectively, which closely agree with those measured by high performance liquid chromatography (HPLC) with UV detector. Therefore, it was concluded that the PPy electrode can be used as an alternative novel potentiometric detector material for determination of sulfamethoxazole in pharmaceuticals with the advantages of easy preparation and regeneration capability of the electrode surface

Morphometric analysis of duodenum in human fetus

WOS: 000388614501358

Medullary nephrocalcinosis in Schimke immuno-osseous dysplasia

PubMedID: 25868949Schimke immuno-osseous dysplasia (SIOD) is a rare hereditary disease characterized by skeletal dysplasia, immune deficiency and progressive renal disease. Kidney involvement mainly determines the prognosis. The most common renal pathology is focal segmental glomerulosclerosis (FSGS). Medullary nephrocalcinosis refers to the diffuse deposition of calcium salts in renal medulla and has not previously been identified in SIOD. Here we report the first case of a pediatric patient having typical features of SIOD with medullary nephrocalcinosis. © 2015 Japan Pediatric Society

Prevalence of cytogenetic abnormalities in chronic lymphocytic leukemia in the southern part of Turkey

PubMedID: 29798961BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia among adults in Western populations. CLL has a wide range of clinical presentations and varied outcomes. For CLL, cytogenetic assessment is essential for estimating prognoses and determining the treatment of choice. The fluorescence in situ hybridization (FISH) technique is widely used for genetic assessment due to its high sensitivity. AIM: This study aimed to evaluate the frequencies of deletions of 13q14.3, 17p13.1, 11q22.3, and 13q34 and of trisomy 12 and to observe their effects on survival in 226 Turkish CLL patients using FISH analysis. RESULT AND CONCLUSION: The frequencies of abnormalities were 65.4% for del 13q14.3, 39.8% for del 17p13.1, 19% for del 11q22.3 (del ATM), and 15.9% for trisomy 12. No patients had a 13q34.3 aberration. Our results are partially consistent with literature findings. However, certain conflicts with prior results were observed, particularly with respect to the high prevalence of 17p13.1 deletions and the enhanced survival of patients with such deletions. These inconsistencies may represent population-based differences in the genetic epidemiology of CLL. © 2018 Indian Journal of Cancer | Pulished by Wolters Kluwer-Medknow

New insights on low vitamin D plasma concentration as a potential cardiovascular risk factor

The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases