Prevalence of Anxiety and Depression Among Respiratory Therapy Professionals in The Western Region of Saudi Arabia

Background: Anxiety and depression are prevalent concerns among psychologists, psychiatric professionals, and behavioral scientists across the world. Anxiety is defined as worry-filled thoughts and a pervasive sense of impending doom. It is a broad concern about what will or might occur in the future. Depression is a debilitating disorder, leading to higher death rates and a significant decline in the quality of life. It is characterized by persistent feelings of sadness, emptiness, and lack of happiness. Therefore, anxiety and depression could have a detrimental effect on the well-being and productivity of respiratory therapists. Purpose: The purpose of this study is to investigate the prevalence and severity of anxiety and depression among respiratory therapists employed by public and private hospitals in the western region of Saudi Arabia. Methods: A cross-sectional study was conducted between September 5 and October 7, 2023. The Hospital Anxiety and Depression Scale (HADS) was distributed electronically to respiratory therapists\u27 email addresses through direct collaboration with RT department heads. Data were collected from RT professionals in both public and private hospitals by using a non-probability convenience sampling technique. The data analysis and statistical description provided by the participants were displayed as means, standard deviations, frequencies, and percentages. A one-way ANOVA test was used to determine the significant differences in HADS scores among categorical groups. Results: A total of 307 responses were received from RTs working in the western region of Saudi Arabia. The majority of them were from public hospitals (74.3%) and (25.7%) from private hospitals. The study findings showed that the prevalence of anxiety and depression among RT professionals in the western of SA were found to be 38.8% and 37.5%, respectively. In addition, HADS scores were significantly higher among RT professionals who were female, current smokers, divorced, or widowed. However, HADS showed that anxiety was significantly higher among RT professionals with clinical experience between 1-4 years as well. Conclusion: Anxiety and depression were common psychological disorders among respiratory therapists in the western region of Saudi Arabia. Higher odds of anxiety and depression were significantly found among females, staff with clinical experience between 1 and 4 years, smokers, and divorced/widowed staff. Further studies are required to investigate the prevalence of depression and anxiety among RTs in all regions of Saudi Arabia

0E2FA: Zero Effort Two-Factor Authentication

Smart devices (mobile devices, laptops, tablets, etc.) can receive signals from different radio frequency devices that are within range. As these devices move between networks (e.g., Wi-Fi hotspots, cellphone towers, etc.), they receive broadcast messages from access points, some of which can be used to collect useful information. This information can be utilized in a variety of ways, such as to establish a connection, to share information, to locate devices, and to identify users, which is central to this dissertation. The principal benefit of a broadcast message is that smart devices can read and process the embedded information without first being connected to the corresponding network. Moreover, broadcast messages can be received only within the range of the wireless access point that sends the broadcast, thus inherently limiting access to only those devices in close physical proximity, which may facilitate many applications that are dependent on proximity. In our research, we utilize data contained in these broadcast messages to implement a two-factor authentication (2FA) system that, unlike existing methods, does not require any extra effort on the part of the users of the system. By determining if two devices are in the same physical location and sufficiently close to each other, we can ensure that they belong to the same user. This system depends on something that a user knows, something that a user owns, and—a significant contribution of this work—something that is in the user’s environment

Secure Mobile Payment Architecture Enabling Multi-factor Authentication

The rise of smartphones has led to a significant increase in the usage of mobile payments. Mobile payments allow individuals to access financial resources and make transactions through their mobile devices while on the go. However, the current mobile payment systems were designed to align with traditional payment structures, which limits the full potential of smartphones, including their security features. This has become a major concern in the rapidly growing mobile payment market. To address these security concerns,in this paper we propose new mobile payment architecture. This architecture leverages the advanced capabilities of modern smartphones to verify various aspects of a payment, such as funds, biometrics, location, and others. The proposed system aims to guarantee the legitimacy of transactions and protect against identity theft by verifying multiple elements of a payment. The security of mobile payment systems is crucial, given the rapid growth of the market. Evaluating mobile payment systems based on their authentication, encryption, and fraud detection capabilities is of utmost importance. The proposed architecture provides a secure mobile payment solution that enhances the overall payment experience by taking advantage of the advanced capabilities of modern smartphones. This will not only improve the security of mobile payments but also offer a more user-friendly payment experience for consumers

Comprehensive Survey: Biometric User Authentication Application, Evaluation, and Discussion

This paper conducts an extensive review of biometric user authentication literature, addressing three primary research questions: (1) commonly used biometric traits and their suitability for specific applications, (2) performance factors such as security, convenience, and robustness, and potential countermeasures against cyberattacks, and (3) factors affecting biometric system accuracy and po-tential improvements. Our analysis delves into physiological and behavioral traits, exploring their pros and cons. We discuss factors influencing biometric system effectiveness and highlight areas for enhancement. Our study differs from previous surveys by extensively examining biometric traits, exploring various application domains, and analyzing measures to mitigate cyberattacks. This paper aims to inform researchers and practitioners about the biometric authentication landscape and guide future advancements

Securing the Invisible Thread: A Comprehensive Analysis of BLE Tracker Security in Apple AirTags and Samsung SmartTags

This study presents an in-depth analysis of the security landscape in Bluetooth Low Energy (BLE) tracking systems, with a particular emphasis on Apple AirTags and Samsung SmartTags, including their cryptographic frameworks. Our investigation traverses a wide spectrum of attack vectors such as physical tampering, firmware exploitation, signal spoofing, eavesdropping, jamming, app security flaws, Bluetooth security weaknesses, location spoofing, threats to owner devices, and cloud-related vulnerabilities. Moreover, we delve into the security implications of the cryptographic methods utilized in these systems. Our findings reveal that while BLE trackers like AirTags and SmartTags offer substantial utility, they also pose significant security risks. Notably, Apple's approach, which prioritizes user privacy by removing intermediaries, inadvertently leads to device authentication challenges, evidenced by successful AirTag spoofing instances. Conversely, Samsung SmartTags, designed to thwart beacon spoofing, raise critical concerns about cloud security and user privacy. Our analysis also highlights the constraints faced by these devices due to their design focus on battery life conservation, particularly the absence of secure boot processes, which leaves them susceptible to OS modification and a range of potential attacks. The paper concludes with insights into the anticipated evolution of these tracking systems. We predict that future enhancements will likely focus on bolstering security features, especially as these devices become increasingly integrated into the broader IoT ecosystem and face evolving privacy regulations. This shift is imperative to address the intricate balance between functionality and security in next-generation BLE tracking systems

Alpha-amylase and alpha-glucosidase enzyme inhibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia

Nuxia oppositifolia is traditionally used in diabetes treatment in many Arabian countries; however, scientific evidence is lacking. Hence, the present study explored the antidiabetic and antioxidant activities of the plant extracts and their purified compounds. The methanolic crude extract of N. oppositifolia was partitioned using a two-solvent system. The n-hexane fraction was purified by silica gel column chromatography to yield several compounds including katononic acid and 3-oxolupenal. Antidiabetic activities were assessed by α-amylase and α-glucosidase enzyme inhibition. Antioxidant capacities were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) scavenging assays. Further, the interaction between enzymes (α-amylase and α-glucosidase) and ligands (3-oxolupenal and katononic acid) was followed by fluorescence quenching and molecular docking studies. 3-oxolupenal and katononic acid showed IC50 values of 46.2 µg/mL (101.6 µM) and 52.4 µg/mL (119.3 µM), respectively against the amylase inhibition. 3-oxolupenal (62.3 µg/mL or 141.9 µM) exhibited more potent inhibition against α-glucosidases compared to katononic acid (88.6 µg/mL or 194.8 µM). In terms of antioxidant activity, the relatively polar crude extract and n-butanol fraction showed the greatest DPPH and ABTS scavenging activity. However, the antioxidant activities of the purified compounds were in the low to moderate range. Molecular docking studies confirmed that 3-oxolupenal and katononic acid interacted strongly with the active site residues of both α-amylase and α-glucosidase. Fluorescence quenching results also suggest that 3-oxolupenal and katononic acid have a good affinity towards both α-amylase and α-glucosidase enzymes. This study provides preliminary data for the plant’s use in the treatment of type 2 diabetes mellitus

Acute Appendicitis among Saudi and Non-Saudi Patients: A Cross-Sectional Based Study

Objective: We conduct this study to discuss the differences between Saudi and non- Saudi patients with acute appendicitis.Background: Acute appendicitis is one of emergency surgeries in developing and developed countries. Its symptoms are vomiting, lower abdominal pain and decreased appetite. Appendicitis needs urgent surgical prouder to avoid its perforation and associated complications which may lead to death. Method: We conduct cross-sectional based study in one of khamis Mushayt, Saudi Araba. 136 patients diagnosed with acute appendicitis were included and their medical records were reviewed after getting their informed consent.Results: We included 136 patients, 90 were non-Saudi and 46 were Saudi. There were no statistically differences in their diagnosis but the distribution of the diagnosis was different.Conclusion: Acute appendicitis was more prevalent among non-Saudi patients, the diagnosis between both was with no significant differences. Keywords: acute appendicitis, Saudi, non-Saudi, diagnosis, cross-sectional, Saudi Arabia and khamis Mushayt

Attenuation of methylglyoxal-induced glycation and cellular dysfunction in wound healing by Centella cordifolia

Current pre-clinical evidences of Centella focus on its pharmacological effects on normal wound healing but there are limited studies on the bioactivity of Centella in cellular dysfunction associated with diabetic wounds. Hence we planned to examine the potential of Centella cordifolia in inhibiting methylglyoxal (MGO)-induced extracellular matrix (ECM) glycation and promoting the related cellular functions. A Cell-ECM adhesion assay examined the ECM glycation induced by MGO. Different cell types that contribute to the healing process (fibroblasts, keratinocytes and endothelial cells) were evaluated for their ability to adhere to the glycated ECM. Methanolic extract of Centella species was prepared and partitioned to yield different solvent fractions which were further analysed by high performance liquid chromatography equipped with photodiode array detector (HPLC-PDA) method. Based on the antioxidant [2,2-diphenyl-1-picrylhydrazyl (DPPH) assay] screening, anti-glycation activity and total phenolic content (TPC) of the different Centella species and fractions, the ethyl acetate fraction of C. cordifolia was selected for further investigating its ability to inhibit MGO-induced ECM glycation and promote cellular distribution and adhesion. Out of the three Centella species (C. asiatica, C. cordifolia and C. erecta), the methanolic extract of C. cordifolia showed maximum inhibition of Advanced glycation end products (AGE) fluorescence (20.20 ± 4.69 %, 25.00 ± 3.58 % and 16.18 ± 1.40 %, respectively). Its ethyl acetate fraction was enriched with phenolic compounds (3.91 ± 0.12 mg CAE/μg fraction) and showed strong antioxidant (59.95 ± 7.18 μM TE/μg fraction) and antiglycation activities. Improvement of cells spreading and adhesion of endothelial cells, fibroblasts and keratinocytes was observed for ethyl acetate treated MGO-glycated extracellular matrix. Significant reduction in attachment capacity of EA.hy926 cells seeded on MGO-glycated fibronectin (41.2%) and attachment reduction of NIH3t3 and HaCaT cells seeded on MGO-glycated collagen (33.7% and 24.1%, respectively) were observed. Our findings demonstrate that ethyl acetate fraction of C. cordifolia was effective in attenuating MGO-induced glycation and cellular dysfunction in the in-vitro wound healing models suggesting that C. cordifolia could be a potential candidate for diabetic wound healing. It could be subjected for further isolation of new phytoconstituents having potential diabetic wound healing properties

A Phytochemical Analysis, Microbial Evaluation and Molecular Interaction of Major Compounds of Centaurea bruguieriana Using HPLC-Spectrophotometric Analysis and Molecular Docking

Centaurea is one of the most important genera within the family Asteraceae. An investigation of the phytochemical composition of Centaurea bruguieriana using Gas-Chromatography coupled to Mass spectrometry (GC-MS) was performed. Antimicrobial activity was evaluated using the minimum inhibitory concentration method (MIC) and validated by molecular docking for the major compounds of the most active fraction (1,10-di-epi-cubenol and methyl 8-oxooctanoate) of C. bruguieriana against three bacterial receptors (TyrRS, DNA gyrase, and dihydrofolate reductase (DHFR)). Evaluation of antioxidant activity was conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. High-performance liquid chromatography (HPLC) was used to identify and quantify the contents of major compounds from ethyl acetate fraction (luteolin 7-O-glucoside, chlorogenic acid, kaempferol and isorhamnetin). The antimicrobial activity test showed that the chloroform fraction was more active against all microbial strains. The results of the molecular docking of two major compounds from chloroform fraction showed that good affinities were made between 1,10-di-epi-cubenol and the three selected receptors (TyrRs: −6.0 Kcal/mol against −8.2 Kcal/mol obtained with clorobiocin (standard); DNA gyrase: −6.6 Kcal/mol against −9.1 Kcal/mole obtained with clorobiocin; DHFR: −7.4 Kcal/mol against −6.3 Kcal/mol obtained with SCHEMBL2181345 Standard). Antioxidant evaluation showed that the ethyl acetate fraction was the most active fraction in DPPH (IC50 49.4 µg/mL) and ABTS (IC50 52.8 µg/mL) models. HPLC results showed the contents of luteolin 7-O-glucoside (7.4 µg/mg), and chlorogenic acid (3.2 µg/mg). Our study demonstrated that C. bruguierana is a promising source of bioactive compounds

A Phytochemical Analysis, Microbial Evaluation and Molecular Interaction of Major Compounds of Centaurea bruguieriana Using HPLC-Spectrophotometric Analysis and Molecular Docking

Centaurea is one of the most important genera within the family Asteraceae. An investigation of the phytochemical composition of Centaurea bruguieriana using Gas-Chromatography coupled to Mass spectrometry (GC-MS) was performed. Antimicrobial activity was evaluated using the minimum inhibitory concentration method (MIC) and validated by molecular docking for the major compounds of the most active fraction (1,10-di-epi-cubenol and methyl 8-oxooctanoate) of C. bruguieriana against three bacterial receptors (TyrRS, DNA gyrase, and dihydrofolate reductase (DHFR)). Evaluation of antioxidant activity was conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. High-performance liquid chromatography (HPLC) was used to identify and quantify the contents of major compounds from ethyl acetate fraction (luteolin 7-O-glucoside, chlorogenic acid, kaempferol and isorhamnetin). The antimicrobial activity test showed that the chloroform fraction was more active against all microbial strains. The results of the molecular docking of two major compounds from chloroform fraction showed that good affinities were made between 1,10-di-epi-cubenol and the three selected receptors (TyrRs: −6.0 Kcal/mol against −8.2 Kcal/mol obtained with clorobiocin (standard); DNA gyrase: −6.6 Kcal/mol against −9.1 Kcal/mole obtained with clorobiocin; DHFR: −7.4 Kcal/mol against −6.3 Kcal/mol obtained with SCHEMBL2181345 Standard). Antioxidant evaluation showed that the ethyl acetate fraction was the most active fraction in DPPH (IC50 49.4 µg/mL) and ABTS (IC50 52.8 µg/mL) models. HPLC results showed the contents of luteolin 7-O-glucoside (7.4 µg/mg), and chlorogenic acid (3.2 µg/mg). Our study demonstrated that C. bruguierana is a promising source of bioactive compounds