Comparative geometrical study of fault-propagation folds associated with lateral tips of thrusts

This work examines the geometry of two examples of fault-propagation folds related to the lateral termination of thrusts. In spite of their differences in age (Variscan and Alpine) and composition of the involved rocks (metamorphic or sedimentary), the geometry of the resulting folds is quite similar, indicating that are universal the mechanisms responsible for these structure

Geotechnical characteristics of the soils of Huelva town: index properties and consolidation test

This paper shows the preliminary results of a laboratory geotechnical test for the identification and determination of consolidation properties of the soils of Huelva. The fine-grained soils (Arcillas de Gibraleón, Arenas de Huelva and Arenas de Bonares units) have a high consistency. These are over-consolidated soils which have few compressibilities. The Arcillas de Gibraleón Unit presents expansive clay mineral

Upper Triassic extensional tectonics at the eastern end of the Algarve basin (Ayamonte, Spain), and the reactivation of faults during the Pliocene-Quaternary

La cartografía geológica realizada en una zona próxima a Ayamonte (Huelva) ha permitido analizar los rasgos geológicos más significativos de un alto estructural en el extremo oriental de la cuenca del Algarve. Se describe el registro estratigráfico de una transgresión durante el Triásico Superior, asociada a un evento extensional de tipo “rifting” relacionado con el inicio de la apertura del océano Atlántico. También se muestra el estilo geométrico de los sistemas de fallas normales simultáneos con la actividad ígnea del Triásico y las deformaciones posteriores. La reactivación de zonas de falla durante el Plioceno-Cuaternario y la exhumación de la paleocobertera mesozoica es planteada en relación con la tectónica reciente ligada a la evolución de la cuenca del GuadalquivirThe geological cartography carried out in an area near Ayamonte (Huelva) allows us to analyze the most significant geological features of a structural high in the eastern end of the Algarve basin. The stratigraphic record of a transgression during the Upper Triassic, associated with a “rifting” event linked to the beginning of the opening of the Atlantic Ocean, is described. The geometric style of the systems of normal faults simultaneous with the igneous activity of the Triassic and the posterior deformations is also shown. The reactivation of the fault zones during the Pliocene-Quaternary and the exhumation of the Mesozoic paleo-cover is proposed in relation to the recent tectonics, linked to the evolution of the Guadalquivir basi

Seismotectonics related to the Azores – Gibraltar Fracture Zone: Analysis of the February 12th 2007 earthquake, SW Gorringe Bank

This work deals with the analysis of the seismicity and tectonic evolution of the eastern end of the Azores – Gibraltar Fracture Zone. The location of the main seismogenetic areas in this region is related to the complex geometry of the boundary between the Iberian and African lithospheric plates. To the west of the San Vicente Cape the seismicity can be related to a local compression at the Gorringe Bank. A detailed seismotectonic analysis allows the geological interpretation of the position of the hypocenter for the 12th February 2007 earthquake. It had Mw 6.0 and was placed on a fault having a NNE-SSW strike and a high dip to NW. The fault shows an oblique displacement (sinistral) and locates in the margin of the Horseshoe abyssal basin. Displacement along this fault is here tentatively related to complex deformation in the outer swell of an incipient downgoing plate. This can be the first indication of the beginning of subduction of the northern part of the African plate under the continental margin of Iberia. On the other hand, an analysis of the location of earthquakes having Mw >6.0 generated to the SW of the San Vicente Cape and the estimated isoseismal map has been made. It can be noted the importance of the uppermost crustal materials on the seismic intensity measurement. Sea waves resulting from these earthquakes and measured in the littoral of the Huelva province have an average velocity of propagation of approximately 600 km/

The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)

Introduction:Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018.Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0.Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016.Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms

Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial

Background: Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment. Methods: This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal. Results: Enrolment began in 2016, and the study is expected to end in 2020. Conclusions: This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission. Clinical trial reference number: EudraCT 2015-001410-1

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality