3,086 research outputs found
New horizons for newborn brain protection: enhancing endogenous neuroprotection.
Intrapartum-related events are the third leading cause of childhood mortality worldwide and result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult typically present with neonatal encephalopathy (NE). The contribution of pure hypoxia-ischaemia (HI) to NE has been debated; over the last decade, the sensitising effect of inflammation in the aetiology of NE and neurodisability is recognised. Therapeutic hypothermia is standard care for NE in high-income countries; however, its benefit in encephalopathic babies with sepsis or in those born following chorioamnionitis is unclear. It is now recognised that the phases of brain injury extend into a tertiary phase, which lasts for weeks to years after the initial insult and opens up new possibilities for therapy.There has been a recent focus on understanding endogenous neuroprotection and how to boost it or to supplement its effectors therapeutically once damage to the brain has occurred as in NE. In this review, we focus on strategies that can augment the body's own endogenous neuroprotection. We discuss in particular remote ischaemic postconditioning whereby endogenous brain tolerance can be activated through hypoxia/reperfusion stimuli started immediately after the index hypoxic-ischaemic insult. Therapeutic hypothermia, melatonin, erythropoietin and cannabinoids are examples of ways we can supplement the endogenous response to HI to obtain its full neuroprotective potential. Achieving the correct balance of interventions at the correct time in relation to the nature and stage of injury will be a significant challenge in the next decade
Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia
Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection. Following hypoxiaâischemia we assessed whether inhaled 45â50% Argon from 2â26 h augmented hypothermia neuroprotection in a neonatal piglet model, using MRS and aEEG, which predict outcome in babies with neonatal encephalopathy, and immunohistochemistry. Following cerebral hypoxiaâischemia, 20 Newborn male Large White piglets < 40 h were randomized to: (i) Cooling (33 °C) from 2â26 h (n = 10); or (ii) Cooling and inhaled 45â50% Argon (Cooling + Argon) from 2â26 h (n = 8). Whole-brain phosphorus-31 and regional proton MRS were acquired at baseline, 24 and 48 h after hypoxiaâischemia. EEG was monitored. At 48 h after hypoxiaâischemia, cell death (TUNEL) was evaluated over 7 brain regions. There were no differences in body weight, duration of hypoxiaâischemia or insult severity; throughout the study there were no differences in heart rate, arterial blood pressure, blood biochemistry and inotrope support. Two piglets in the Cooling + Argon group were excluded. Comparing Cooling + Argon with Cooling there was preservation of whole-brain MRS ATP and PCr/Pi at 48 h after hypoxiaâischemia (p < 0.001 for both) and lower 1H MRS lactate/N acetyl aspartate in white (p = 0.03 and 0.04) but not gray matter at 24 and 48 h. EEG background recovery was faster (p < 0.01) with Cooling + Argon. An overall difference between average cell-death of Cooling versus Cooling + Argon was observed (p < 0.01); estimated cells per mm2 were 23.9 points lower (95% C.I. 7.3â40.5) for the Cooling + Argon versus Cooling. Inhaled 45â50% Argon from 2â26 h augmented hypothermic protection at 48 h after hypoxiaâischemia shown by improved brain energy metabolism on MRS, faster EEG recovery and reduced cell death on TUNEL. Argon may provide a cheap and practical therapy to augment cooling for neonatal encephalopathy
pretreatment with the monoacylglycerol lipase inhibitor urb602 protects from the long term consequences of neonatal hypoxic ischemic brain injury in rats
Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxicâischemic brain injury in rat
Z boson production in p+Pb collisions at sNNâ=5.02 TeV measured with the ATLAS detector
The ATLAS Collaboration has measured the inclusive production of Z bosons via their decays into electron and muon pairs in p+Pb collisions at â sNN = 5.02 TeV at the Large Hadron Collider. The measurements are made using data corresponding to integrated luminosities of 29.4 nbâ1 and 28.1 nbâ1 for Z â ee and Z â ””, respectively. The results from the two channels are consistent and combined to obtain a cross section times the Z â `` branching ratio, integrated over the rapidity region |y â Z | < 3.5, of 139.8 ± 4.8 (stat.) ± 6.2 (syst.) ± 3.8 (lumi.) nb. Differential cross sections are presented as functions of the Z boson rapidity and transverse momentum, and compared with models based on parton distributions both with and without nuclear corrections. The centrality dependence of Z boson production in p+Pb collisions is measured and analyzed within the framework of a standard Glauber model and the modelâs extension for fluctuations of the underlying nucleon-nucleon scattering cross sectionFil: Aad, G.. Aix-Marseille UniversitĂ©; FranciaFil: Abbott, B.. Oklahoma State University; Estados UnidosFil: Abdallah, J.. Academia Sinica; ChinaFil: Abdinov, O.. Azerbaijan Academy of Sciences; AzerbaiyĂĄnFil: Aben, R.. University of Amsterdam; PaĂses BajosFil: Alconada Verzini, MarĂa Josefina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Alonso, Francisco. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Arduh, Francisco Anuar. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Dova, Maria Teresa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Wahlberg, Hernan Pablo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Otero y Garzon, Gustavo Javier. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de FĂsica de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de FĂsica de Buenos Aires; ArgentinaFil: Piegaia, Ricardo Nestor. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de FĂsica de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de FĂsica de Buenos Aires; ArgentinaFil: Reisin, Hernan Diego. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de FĂsica de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de FĂsica de Buenos Aires; ArgentinaFil: Sacerdoti, Sabrina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Ciudad Universitaria. Instituto de FĂsica de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de FĂsica de Buenos Aires; ArgentinaFil: Zieminska, D.. Indiana University; Estados UnidosFil: Zimine, N. I.. Joint Institute for Nuclear Research ; RusiaFil: Zimmermann, C.. UniversitĂ€t Mainz; AlemaniaFil: Zimmermann, S.. Albert-Ludwigs-UniversitĂ€t; AlemaniaFil: Zinonos, Z.. Georg-August-UniversitĂ€t; AlemaniaFil: Zinser, M.. UniversitĂ€t Mainz; AlemaniaFil: Ziolkowski, M.. UniversitĂ€t Siegen ; AlemaniaFil: ĆœivkoviÄ, L.. University of Belgrade; SerbiaFil: Zobernig, G.. University of Wisconsin; Estados UnidosFil: Zoccoli, A.. UniversitĂ di Bologna; ItaliaFil: Nedden, M. zur. Humboldt University; AlemaniaFil: Zurzolo, G.. UniversitĂ di Napoli; ItaliaFil: Zwalinski, L.. Cern - European Organization For Nuclear Research; SuizaFil: The ATLAS Collaboration. No especifica
Triggers for displaced decays of long-lived neutral particles in the ATLAS detector
A set of three dedicated triggers designed to detect long-lived neutral particles decaying throughout the ATLAS detector to a pair of hadronic jets is described. The efficiencies of the triggers for selecting displaced decays as a function of the decay position are presented for simulated events. The effect of pile-up interactions on the trigger efficiencies and the dependence of the trigger rate on instantaneous luminosity during the 2012 data-taking period at the LHC are discussedFil: Aad, G.. Albert Ludwigs UniversitĂ€t; AlemaniaFil: Abajyan, T.. Universitaet Bonn; AlemaniaFil: Abbott, B.. University of Oklahoma; Estados UnidosFil: Abdallah, J.. Universitat AutĂČnoma de Barcelona; EspañaFil: Abdel Khalek, S.. Universite Paris Sud; FranciaFil: Alconada Verzini, MarĂa Josefina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Alonso, Francisco. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Anduaga, Xabier Sebastian. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Dova, Maria Teresa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: GonzĂĄlez Silva, MarĂa Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FĂsica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Monticelli, Fernando Gabriel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Otero y Garzon, Gustavo Javier. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FĂsica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Piegaia, Ricardo Nestor. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FĂsica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Romeo, Gaston Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de FĂsica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Tripiana, Martin Fernando. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; ArgentinaFil: Zhuang, X.. Ludwig Maximilians Universitat; AlemaniaFil: Zhuravlov, V.. Max-Planck Institut fĂŒr Physik; AlemaniaFil: Zieminska, D.. Indiana University; Estados UnidosFil: Zimin, N. I.. Joint Institute for Nuclear Research; RusiaFil: Zimmermann, R.. Universitaet Bonn; AlemaniaFil: Zimmermann, S.. Universitaet Bonn; AlemaniaFil: Zimmermann, S.. Albert Ludwigs UniversitĂ€t; AlemaniaFil: Ziolkowski, M.. UniversitĂ€t Siegen; AlemaniaFil: Zitoun, R.. UniversitĂ© de Savoie; FranciaFil: ĆœivkoviÄ, L.. Columbia University; Estados UnidosFil: Zmouchko, V. V.. State Research Center Institute for High Energy Physics; RusiaFil: Zobernig, G.. University of Wisconsin; Estados UnidosFil: Zoccoli, A.. UniversitĂ di Bologna; ItaliaFil: zur Nedden, M.. Humboldt University; AlemaniaFil: Zutshi, V.. Northern Illinois University; Estados Unido
Measurement of the parity-violating asymmetry parameter αb and the helicity amplitudes for the decay Î0bâJ/Ï+Î0 with the ATLAS detector
A measurement of the parity-violating decay asymmetry parameter, αb, and the helicity amplitudes for the decay Îb0âJ/Ï(ÎŒ+ÎŒ-)Î0(pÏ-) is reported. The analysis is based on 1400 Îb0 and ÎÂŻb0 baryons selected in 4.6ââfb-1 of proton-proton collision data with a center-of-mass energy of 7 TeV recorded by the ATLAS experiment at the LHC. By combining the Îb0 and ÎÂŻb0 samples under the assumption of CP conservation, the value of αb is measured to be 0.30±0.16(stat)±0.06(syst). This measurement provides a test of theoretical models based on perturbative QCD or heavy-quark effective theory.Fil: F. Monticelli.Fil: Atlas Collaboration
Measurement of the production of a W boson in association with a charm quark in pp collisions at sqrt(s)=7 TeV with the ATLAS detector
The production of a W boson in association with a single charm quark is studied using 4.6 fb^-1 of pp collision data at sqrt(s)=7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96 +0.26 -0.30 at Q^2=1.9 GeV^2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio sigma(W^+ + bar{c})/sigma(W^- + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s-bar{s} quark asymmetry.Fil: ATLAS Collaboration, G. AAd, F. Monticelli, et al. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto de FĂsica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de FĂsica La Plata; Argentina. Cern - European Organization For Nuclear Research; Suiz
Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. Our aim was to assess whether RIPostC is protective following cerebral hypoxia-ischemia in a piglet model of neonatal encephalopathy (NE) using magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry. After hypoxia-ischemia (HI), 16 Large White female newborn piglets were randomized to: (i) no intervention (nâ=â8); (ii) RIPostC - with four, 10-min cycles of bilateral lower limb ischemia/reperfusion immediately after HI (nâ=â8). RIPostC reduced the hypoxic-ischemic-induced increase in white matter proton MRS lactate/N acetyl aspartate (pâ=â0.005) and increased whole brain phosphorus-31 MRS ATP (pâ=â0.039) over the 48âh after HI. Cell death was reduced with RIPostC in the periventricular white matter (pâ=â0.03), internal capsule (pâ=â0.002) and corpus callosum (pâ=â0.021); there was reduced microglial activation in corpus callosum (pâ=â0.001) and more surviving oligodendrocytes in corpus callosum (pâ=â0.029) and periventricular white matter (pâ=â0.001). Changes in gene expression were detected in the white matter at 48âh, including KATP channel and endothelin A receptor. Immediate RIPostC is a potentially safe and promising brain protective therapy for babies with NE with protection in white but not grey matter
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Z boson production in Pb+Pb collisions at âSnn = 5.02 TeV measured by the ATLAS experiment
The production yield of Z bosons is measured in the electron and muon decay channels in Pb+Pb collisions at âS = 5.02 TeV with the ATLAS detector. Data from the 2015 LHC run corresponding to an integrated luminosity of 0.49 nb are used for the analysis. The Z boson yield, normalised by the total number of minimum-bias events and the mean nuclear thickness function, is measured as a function of dilepton rapidity and event centrality. The measurements in Pb+Pb collisions are compared with similar measurements made in proton-proton collisions at the same centre-of-mass energy. The nuclear modification factor is found to be consistent with unity for all centrality intervals. The results are compared with theoretical predictions obtained at next-to-leading order using nucleon and nuclear parton distribution functions. The normalised Z boson yields in Pb+Pb collisions lie 1-3Ï above the predictions. The nuclear modification factor measured as a function of rapidity agrees with unity and is consistent with a next-to-leading-order QCD calculation including the isospin effect. nn -
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