Solutions of the dispersion equation in the region of overlapping of zero-sound and particle-hole modes

In this paper the solutions of the zero-sound dispersion equation in the random phase approximation (RPA) are considered. The calculation of the damped zero-sound modes \omega_s(k) (complex frequency of excitation) in the nuclear matter is presented. The method is based on the analytical structure of the polarization operators \Pi(\omega,k). The solutions of two dispersion equations with \Pi(\omega,k) and with Re(\Pi(\omega,k)) are compared. It is shown that in the first case we obtain one-valued smooth solutions without "thumb-like" forms. Considering the giant resonances in the nuclei as zero-sound excitations we compare the experimental energy and escape width of the giant dipole resonance (GDR) in the nucleus A with \omega_s(k) taken at a definite wave vector k=k_A.Comment: 14 pages, 5 figures; revised versio

Kinks in the Hartree approximation

The topological defects of the lambda phi^4 theory, kink and antikink, are studied in the Hartree approximation. This allows us to discuss quantum effects on the defects in both stationary and dynamical systems. The kink mass is calculated for a number of parameters, and compared to classical, one loop and Monte Carlo results known from the literature. We discuss the thermalization of the system after a kink antikink collision. A classical result, the existence of a critical speed, is rederived and shown for the first time in the quantum theory. We also use kink antikink collisions as a very simple toy model for heavy ion collisions and discuss the differences and similarities, for example in the pressure. Finally, using the Hartree Ensemble Approximation allows us to study kink antikink nucleation starting from a thermal (Bose Einstein) distribution. In general our results indicate that on a qualitative level there are few differences with the classical results, but on a quantitative level there are some import ones.Comment: 20 pages REVTeX 4, 17 Figures. Uses amsmath.sty and subfigure.sty. Final version, fixed typo in published versio

Meson Screening Mass in a Strongly Coupled Pion Superfluid

We calculate the meson screening mass in a pion superfluid in the framework of Nambu--Jona-Lasinio model. The minimum of the attractive quark potential is always located at the phase boundary of pion superfluid. Different from the temperature and baryon density effect, the potential at finite isospin density can not be efficiently suppressed and the matter is always in a strongly coupled phase due to the Goldstone mode in the pion superfluid.Comment: 8 pages, 7 figures(Accepted by European Physical Journal C

Efficacy and safety of the combination of reduced duration prophylaxis followed by immuno-guided prophylaxis to prevent cytomegalovirus disease in lung transplant recipients (CYTOCOR STUDY) : An open-label, randomised, non-inferiority clinical trial

Introduction Prolonged use of antivirals to prevent the development of cytomegalovirus (CMV) disease in lung transplant patients has been shown to have significant side effects, for which alternatives are being sought to reduce their use. The monitoring of cell immunity against CMV could be an alternative as it has shown to be useful in identifying transplant patients at low risk of infection, who could benefit from shorter prophylaxis. The aim of the CYTOCOR study is to demonstrate that the combination of a reduced prophylaxis strategy with subsequent CMV-specific immunological monitoring would allow CMV infection to be controlled in lung transplant patients as effectively as the usual strategy (prophylaxis followed by pre-emptive therapy), while reducing the side effects of antivirals due to the shorter duration of prophylaxis. Methods and analysis Phase III randomised, open, multicentre, parallel, non-inferiority clinical trial to study the efficacy and safety of the combination of a prophylaxis strategy up to month +3 post-transplant followed by immuno-guided prophylaxis using the QuantiFERON-CMV technique up to month +12 post-transplant to prevent CMV disease in CMV-seropositive lung transplant recipients. This strategy will be compared with a combination of a usual prophylaxis strategy up to month +6 post-transplant followed by pre-emptive therapy up to month +12. To study the incidence of CMV disease, patients will be followed up to 18 months post-transplantation. A total of 150 patients are expected to be recruited for the study. Ethics and public dissemination The clinical trial has been approved by the Research Ethics Committees and authorised by the Spanish Agency of Medicines and Medical Devices (AEMPS). If the hypothesis of this clinical trial is verified, the dissemination of the results could change clinical practice by increasing knowledge about the safety and efficacy of discontinuing valganciclovir prophylaxis in lung transplant recipients. Trial registration number NCT03699254

One loop renormalization of the four-dimensional theory for quantum dilaton gravity.

We study the one loop renormalization in the most general metric-dilaton theory with the second derivative terms only. The general theory can be divided into two classes, models of one are equivalent to conformally coupled with gravity scalar field and also to general relativity with cosmological term. The models of second class have one extra degree of freedom which corresponds to dilaton. We calculate the one loop divergences for the models of second class and find that the arbitrary functions of dilaton in the starting action can be fine-tuned in such a manner that all the higher derivative counterterms disappear on shell. The only structures in both classical action and counterterms, which survive on shell, are the potential (cosmological) ones. They can be removed by renormalization of the dilaton field which acquire the nontrivial anomalous dimension, that leads to the effective running of the cosmological constant. For some of the renormalizable solutions of the theory the observable low energy value of the cosmological constant is small as compared with the Newtonian constant. We also discuss another application of our result.Comment: 21 pages, latex, no figures

Ab Initio Calculation of the Lattice Distortions induced by Substitutional Ag- and Cu- Impurities in Alkali Halide Crystals

An ab initio study of the doping of alkali halide crystals (AX: A = Li, Na, K, Rb; X = F, Cl, Br, I) by ns2 anions (Ag- and Cu-) is presented. Large active clusters with 179 ions embedded in the surrounding crystalline lattice are considered in order to describe properly the lattice relaxation induced by the introduction of substitutional impurities. In all the cases considered, the lattice distortions imply the concerted movement of several shells of neighbors. The shell displacements are smaller for the smaller anion Cu-, as expected. The study of the family of rock-salt alkali halides (excepting CsF) allows us to extract trends that might be useful at a predictive level in the study of other impurity systems. Those trends are presented and discussed in terms of simple geometric arguments.Comment: LaTeX file. 8 pages, 3 EPS pictures. New version contains calculations of the energy of formation of the defects with model clusters of different size

The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus

Introduction: Challenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target. Background: Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERβ shows promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knockout mice indicate beneficial actions of selective agonists of ERβ receptor and underscore its therapeutic potential. Conclusion: Studies are needed to further elucidate the exact mechanism underlying the role of ERβ activation as a therapeutic approach in the management of type 2 diabetes