909 research outputs found
Programmable biomaterials for dynamic and responsive drug delivery
Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the recent advances being made in regards to programming biomaterials for improved drug delivery, with a focus on cancer and infection. We begin by explaining several of the underlying concepts that are being used to design this new wave of drug delivery vehicles, followed by examining recent materials systems that are able to coordinate the temporal delivery of multiple therapeutics, dynamically respond to changing tissue environments, and reprogram their bioactivity over time
Guidelines for health administrators and other health professionals in working with people with disabilities
Includes bibliographical references.The focus of this manual is to provide guidelines for health administrators and other health professionals in working with patients and other possible hospital employees with disabilities. This includes an overview of the American Disabilities Act of 1990, dealing with health professionals and hospital employees. This manual provides a detailed outline of the ADA and how to incorporate the act with how hospitals are operated. This component is virtually nonexistent in most hospitals. The manual provides some suggestions on how to deal with people with various cognitive, health disabilities, such as visual, hearing, behavioral, motor, and other various disabilities that affect people. This guide lines manual also gives another perspective on working employees with disabilities and what to expect from them in spite of their disabilities.B.S.Ed. (Bachelor of Science in Education
A comparison of system (O\u3csub\u3e2\u3c/sub\u3e and CO\u3csub\u3e2\u3c/sub\u3e) and C-14 measurements of metabolism in estuarine mesocosms
Metabolism in estuarine mesocosms was measured by total system oxygen and carbon dioxide and by C-14 bottle incubations to determine the effects of nutrient enrichment (6 levels) over a 9 mo period. These data provided an unprecedented opportunity for calculating metabolic ratios (photosynthetic quotient [P.Q.] and respiratory quotient [R.Q.]) based on the 3 measures of metabolism and determining the impact of other system processes. System metabolism ratios based on daily data varied from 0 to 5.0. System metabolism ratios of P.Q. and R Q. based on integrated data were highly correlated (r = 0.95 to 0.96) and similar to traditional ratios obtained in phytoplankton studies. A system photosynthetic quotient of 1.2 and a system respiratory quotient of 1.1 were calculated from the integrated data. These ratios were only slightly affected by carbon dioxide diffusion and 3 benthic processes: denitrification, sulfur metabolism and calcium carbonate dissolution. There was no trend for system metabolism ratios up the nutrient gradient. The C-14 estimations of productivity appeared nitrogen limited in the lower nutrient treatments and provided lower estimates than the 2 system measures of production
Peculiarities in produced particles emission in 208Pb + Ag(Br) interactions at 158 A GeV/c
The angular structures of particles produced in 208Pb induced collisions with
Ag(Br) nuclei in an emulsion detector at 158 A GeV/c have been investigated.
Nonstatistical ring-like substructures in azimuthal plane of the collision have
been found and their parameters have been determined. The indication on the
formation of the ring-like substructures from two symmetrical emission cones -
one in the forward and other in the backward direction in the center-of mass
system have been obtained. The ring-like substructures parameters have been
determined. The experimental results are in an agreement with I.M. Dremin idea,
that mechanism of the ring-like substructures formation in nuclear collisions
is similar to that of Cherenkov electromagnetic radiation.Comment: 10 pages, 7 figures, Report at the HADRON STRUCTURE'04 Conference,
Smolenice, Slovakia, 30.8.-3.9.200
Unraveling the Pharmacokinetic Interaction of Ticagrelor and MEDI2452 (Ticagrelor Antidote) by Mathematical Modeling
The investigational ticagrelor-neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis nontrivial and mathematical modeling becomes essential to unravel the complex behavior of this system. We propose a mechanistic PK model, including a special observation model for post-sampling equilibration, which is validated and refined using mouse in vivo data from four studies of combined ticagrelor-MEDI2452 treatment. Model predictions of free ticagrelor and TAM plasma concentrations are subsequently used to drive a pharmacodynamic (PD) model that successfully describes platelet aggregation data. Furthermore, the model indicates that MEDI2452-bound ticagrelor is primarily eliminated together with MEDI2452 in the kidneys, and not recycled to the plasma, thereby providing a possible scenario for the extrapolation to humans. We anticipate the modeling work to improve PK and PD understanding, experimental design, and translational confidence
Strangeness Enhancement Scenarios: Fireball or Independent Strings?
Due to the long-standing discrepancy between NA35 and NA36 data on
production, two drastically different scenarios of strangeness enhancement are
still possible. Independent string models, such as the dual parton model, lead
to results close to the NA36 data. On the contrary, the NA35 results can only
be described by introducing full final state rescattering of the produced
particles. The corresponding predictions for central - collisions at
CERN energies differ by a factor 3 to 4. Preliminary data on the net proton
(-) rapidity distribution in - collisions favor the
independent string scenario.Comment: 12 pages, Plain Tex, no figure
Simulation of Light Antinucleus-Nucleus Interactions
Creations of light anti-nuclei (anti-deuterium, anti-tritium, anti-He3 and
anti-He4) are observed by collaborations at the LHC and RHIC accelerators. Some
cosmic ray experiments are aimed to find the anti-nuclei in cosmic rays. To
support the experimental studies of the anti-nuclei a Monte Carlo simulation of
anti-nuclei interactions with matter is implemented in the Geant4 toolkit. The
implementation combines practically all known theoretical approaches to the
problem of antinucleon-nucleon interactions.Comment: 8 pages, 5 figure
Parton cascade description of relativistic heavy-ion collisions at CERN SPS energies ?
We examine Pb+Pb collisions at CERN SPS energy 158 A GeV, by employing the
earlier developed and recently refined parton-cascade/cluster-hadronization
model and its Monte Carlo implementation. This space-time model involves the
dynamical interplay of perturbative QCD parton production and evolution, with
non-perturbative parton-cluster formation and hadron production through cluster
decays. Using computer simulations, we are able to follow the entwined
time-evolution of parton and hadron degrees of freedom in both position and
momentum space, from the instant of nuclear overlap to the final yield of
particles. We present and discuss results for the multiplicity distributions,
which agree well with the measured data from the CERN SPS, including those for
K mesons. The transverse momentum distributions of the produced hadrons are
also found to be in good agreement with the preliminary data measured by the
NA49 and the WA98 collaboration for the collision of lead nuclei at the CERN
SPS. The analysis of the time evolution of transverse energy deposited in the
collision zone and the energy density suggests an existence of partonic matter
for a time of more than 5 fm.Comment: 16 pages including 7 postscript figure
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