Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence

Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the needs of the patients. In particular, geriatric and paediatric populations as well as dermatological patients have special needs/preferences that should be considered when designing drug products. Patient Centric Drug Product Pharmaceutical Design (PCDPD) offers the opportunity to meet the needs and preferences of patients. Packaging, orodispersible formulations, fixed dose combinations products, multiparticulate formulations, topical formulations and 3D printing are of particular relevance in a PCDPD process. These will be addressed in this review as well as their impact on medication adherence

Estudos sobre a nutrição mineral do arroz: XV. absorção radicular e foliar do radiofosforo pelas variedades IAC-47 e IAC-435

Foram estudados os efeitos do tempo e da concentração iônica externa na absorção do radiofósforo por raízes destacadas e por plantas inteiras de arroz das variedades IAC-47 (sequeiro) e IAC-435 (irrigado). No intervalo de 30 a 180 min. houve linearidade na absorção. O valor de km para as duas variedades foi o mesmo sendo, porém, menor quando se empregaram raízes destacadas. Não se encontrou diferença significativa na absorção foliar do fosfato monoamônico ou diamônico em ausência ou em presença de uréia.Root uptake either by excised roots or by intact young plants (3-4 week old) showed linearity in the period from 30 to 180 minutes of contact with the solution. Km values were the same for both varieties being, however, slightly lower in the case of excised roots. Foliar uptake was affect neither by source (monoammonium against diammonium phosphate) nor by the presence of urea in the same solution

Signatures of Right-Handed Majorana neutrinos and gauge bosons in eγe \gamma Collisions

The process $e^- \gamma \to e^+ W_R^- W_R^-$ is studied in the framework of the Left-Right symmetric model. It is shown that this reaction and $e^- \gamma \to l^+ W_R^- W_R^-$ for the arbitrary final lepton are likely to be discovered for CLIC collider option. For relatively light doubly charged Higgs boson its mass does not have much influence on the discovery potential, while for heavier values the probability of the reaction increases.Comment: 18 pages, 7 figures, LaTe