Precedents of Archaeology of the Architecture in art historiography : Francisco M.ª Tubino’s studies in the Alcázar of Seville (1885)

Con este artículo pretendemos contribuir a la conciliación entre los estudios de Historia del Arte y de Arqueología de la Arquitectura, disciplinas que frecuentemente se han visto enfrentadas debido, fundamentalmente, a desavenencias entre sus métodos de trabajo. Para ello, presentamos y estudiamos un caso concreto, el de los estudios arqueológicos y artísticos llevados a cabo por Francisco M.ª Tubino en el Alcázar de Sevilla durante 1885. Estos trabajos fueron los primeros en realizarse en el conjunto monumental con un método de investigación analítico y sistemático, constituyendo un punto de inflexión en la historiografía artístico-arqueológica del siglo XIX. Consideramos que son fiel reflejo de una época en la cual los perfiles de historiador del arte y de arqueólogo no estaban tan definidos como en la actualidad, y que bien pueden ilustrarnos acerca de las ventajas que trae consigo la vinculación y coordinación entre los métodos arqueológicos y los histórico-artísticos.With this paper we try to intend to contribute to the reconciliation with the studies about Art History and Archaeology of Architecture, often confronted because methodological differences. Therefore, we present the archaeologic and artistic studies undertaken by Francisco M.ª Tubino in 1885 in the Alcázar of Seville. This work was the first been made supported by a methodological practice in this monumental site, and it marks a turning point about artistic and archaeologic historiography. Tubino’s work is a reflection of a time when there wasn’t any difference between the art historian and the archaeologist and it may illustrate about teamwork between archaeologic and historical artistic methodology

Author Correction: Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Four patients with a history of acute exacerbations of COPD: implementing the CHEST/Canadian Thoracic Society guidelines for preventing exacerbations

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Pasionaria murciana : la cuaresma y la semana santa en Murcia : costumbres, romancero, procesiones, esculturas y escultores, cantos populares, folk-lore

Contiene : Addenda et corrigenda, año 1898 (p. 251-282

Evolution of crystalline orientations in the production of ferritic stainless steel

Ferritic stainless steel EN 1.4016 is used in a wide range of applications, the most common ones related to sheet forming. Several problems in the post-processing of these steels relates to their texture and anisotropy. Therefore, it is necessary to know the mechanisms of texture formation in the subsequent stages of metal manufacturing processes. EBSD has been demonstrated as a successful characterisation technique for this purpose. It is known that during re-crystallisation of Fe-Cr steels, deviations from the desired.-fibre texture promote a decrease of deep drawability. Additionally, a-fibre damages formability. Subsequent cold rolling and annealing can enhance the deep drawing properties of the steel sheet. In this research, a standard sample and a modified one with optimised settings as regard to chemical composition and manufacturing process, to improve the formability properties, are characterised. To analyse the preferred orientation and the type of main fibre present in the material, ODF and Aztec Reclassify Phase, to calculate the content of martensite, were used

Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites.

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to mosquitoes. Here, we summarize evidence for naturally acquired anti-gametocyte immunity and the current state of transmission blocking vaccines (TBV). Although gametocytes are intra-erythrocytic when present in infected humans, developing Plasmodium falciparum gametocytes may express proteins on the surface of red blood cells that elicit immune responses in naturally exposed individuals. This immune response may reduce the burden of circulating gametocytes. For both P. falciparum and Plasmodium vivax, there is a solid evidence that antibodies against antigens present on the gametocyte surface, when co-ingested with gametocytes, can influence transmission to mosquitoes. Transmission reducing immunity, reducing the burden of infection in mosquitoes, is a well-acknowledged but poorly quantified phenomenon that forms the basis for the development of TBV. Transmission enhancing immunity, increasing the likelihood or intensity of transmission to mosquitoes, is more speculative in nature but is convincingly demonstrated for P. vivax. With the increased interest in malaria elimination, TBV and monoclonal antibodies have moved to the center stage of malaria vaccine development. Methodologies to prioritize and evaluate products are urgently needed

Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin

In the accompanying Comment, Suzuki et al. confirmed our previous findings that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) does not functionally inhibit the NMDAR at concentrations relevant to its antidepressant actions recently reported in mice (that is, approximately 10 μM)

A Preliminary Analysis of the Immunoglobulin Genes in the African Elephant (Loxodonta africana)

The genomic organization of the IgH (Immunoglobulin heavy chain), Igκ (Immunoglobulin kappa chain), and Igλ (Immunoglobulin lambda chain) loci in the African elephant (Loxodonta africana) was annotated using available genome data. The elephant IgH locus on scaffold 57 spans over 2,974 kb, and consists of at least 112 VH gene segments, 87 DH gene segments (the largest number in mammals examined so far), six JH gene segments, a single μ, a δ remnant, and eight γ genes (α and ε genes are missing, most likely due to sequence gaps). The Igκ locus, found on three scaffolds (202, 50 and 86), contains a total of 153 Vκ gene segments, three Jκ segments, and a single Cκ gene. Two different transcriptional orientations were determined for these Vκ gene segments. In contrast, the Igλ locus on scaffold 68 includes 15 Vλ gene segments, all with the same transcriptional polarity as the downstream Jλ-Cλ cluster. These data suggest that the elephant immunoglobulin gene repertoire is highly diverse and complex. Our results provide insights into the immunoglobulin genes in a placental mammal that is evolutionarily distant from humans, mice, and domestic animals