Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin

Audigier, Y.; Bai, Y.; Barak, L.S.; Caron, M.G.; Chaves-Almagro, C.; Huang, X.-P.; Kang, H.J.; Knibiehler, B.; Le Gonidec, S.; Masri, B.; Prats, H.; Roth, B.L.; Smith, A.; Valet, P.; Wanecq, E.

Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin

Authors: Y. Audigier
Y. Bai
L.S. Barak
M.G. Caron
C. Chaves-Almagro
X.-P. Huang
H.J. Kang
B. Knibiehler
S. Le Gonidec
B. Masri
H. Prats
B.L. Roth
A. Smith
P. Valet
E. Wanecq
Publication date: 1 January 2017
Publisher: FASEB
Doi

Abstract

In the accompanying Comment, Suzuki et al. confirmed our previous findings that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) does not functionally inhibit the NMDAR at concentrations relevant to its antidepressant actions recently reported in mice (that is, approximately 10 μM)

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