The implications of nursing degree education for future workforce planning in Saudi Arabia : a case study

Health system reconfiguration in Saudi Arabia as a response to changing demographics and related health needs is an important and timely driver for the development of nurse education, specifically, the introduction of degree education as a basic requirement for nursing practice. The Saudi government is trying to meet international standards by implementing a change to nurse education by making it an all degree profession. However, as a result, there are many challenges that still need addressing. Utilising a qualitative case study approach, documentary analysis was undertaken and semi-structured interviews were conducted with twenty-five key stakeholders in order to critically assess the actual implications of a nursing degree as the baseline criteria for and to enter nursing practice. The formal and informal documentary analysis indicated that there was a clear lack of involvement from nurses in the consultation process prior to implementing the degree education policy. However, the interviews conducted with nursing staff (at a macro, meso and micro level) indicated general agreement that a Bachelor degree in nursing would further support the knowledge and communication requirements for improving the quality of nursing practice. Factors affecting degree attainment included a personal commitment/passion for self-improvement, private versus government institutions, the quality of programmes of education and financial issues. Data indicated the increased knowledge base gained through degree education, supported a growth in confidence, decreased absenteeism, enhanced nursing skills and responsibilities, and gave opportunity for advancement. More importantly, such benefits increased the quality of nursing practice and patient safety outcomes. Recommendations based on the findings of this study, highlight the importance of a process of consultation between governmental bodies and relevant nursing staff, who are affected by future policy changes. The need for a national curriculum, and a differentiation of nursing job descriptions, based on the education level attained, together with improved clinical supervision for nurses in practice

Strategies for Whole-exome Sequencing Analysis in A Case Series Study of Familial Male Infertility

Background: Infertility is one of the common health issues around the world. The prevalence of male factor infertility among infertile couples is approximately 30%- 35%, of which genetic factors account for 15%. The family-based whole-exome sequencing (WES) approach can accurately detect novel variants. However, selecting an appropriate sample for data generation using WES has proven to be challenging in familial male infertility studies. The aim of this study was to identify types of pathogenic male infertility in cases of familial asthenozoospermia. Case: Two families with multiple cases were recruited for the purpose of WES. The study population included two affected cases in pedigree I and three affected cases in pedigree II. Two different variant callers (SAMtools and GATK) with a single-sample calling strategy (SSCS) and a multiple-sample calling strategy (MSCS), were applied to identify variant sites. Conclusion: In this study, we represented the results for variant prioritization of WES data without sequencing fertile siblings in the same pedigree by applying two different pipelines (homozygosity and linkage-based strategy). Using the aforementioned strategies, we prioritized annotated variants and generated a logical shortlist of private variants for each pedigree. Key words: Male infertility, Whole-exome sequencing, GATK, SAMtools

Another look at the 2009 seismic activity, Harrat Lunayyir, Saudi Arabia

This study aims to recognize the influence of source- and path-effects on seismic spectra using the waveform data from the 2009 seismic activity, Harrat Lunayyir (HL), eastern flank of the Red Sea coastline, Saudi Arabia. This seismic activity is considered as a series of continuously evolving events reaching at some stage the maximum on 19 May 2009, with the largest shock of Mw 5.4, and then decayed. A total number of 218 events of magnitudes ML ≥ 2.0 were analyzed, which include the largest shock, 101 and 116 seismic events representing the seismic events within the early and decay stages, respectively. The data analysis using Frequency-time analysis revealed diversity patterns of frequency contents along the recorded seismic stations. Moreover, the modified WADATI diagram showed VP/VS variations of 1.7 ± 0.003 and 1.72 ± 0.002 before and after the occurrence of the largest-sized event among the HL seismic activity, respectively. Using the grid-search method to recover the space parameters representing the average source spectrum of each earthquake over the recorded seismic stations, estimates of source sizes and stress drops imply variations in self-similarity scaling relationship among the HL seismic activity. According to the results obtained from the current analyses, we propose a scenario began with an emplacement of seismic activity due to the local stress accumulation imports from an upward dike injection that is blocked by cooled and hardened magmatic materials in the upper crust from the earlier intrusions. The stress accumulation continued and was then released, at some stage, by the event having the maximum magnitude followed by seismic activities released due to stress relaxations

Impact of resilience and environmental stress on burnout of students in public and private dental schools in Western Saudi Arabia.

Dental students' burnout has been repeatedly reported in the literature; however, there is little information about the contributing factors in different contexts and settings. This study aimed to investigate the correlation between burnout among undergraduate dental students and sociodemographic (specifically gender), psychological (resilience), and structural factors (dental environment stress). An online cross-sectional survey questionnaire was distributed among a convenience sample of 500 undergraduate Saudi dental students. The survey included questions about sociodemographic factors (gender, level of education, academic achievement, type of school [public or private], and living arrangements). The study also included items that allowed assessment of students' burnout using the Maslach Burnout Inventory (MBI) and assessment of student environmental stress and resilience using the Dental Environment Stress Scale (DESS) and the Brief Resilience Scale (BRS). Descriptive statistics, univariate, and linear regression analyses were performed. The response rate was 67% (male = 119, female = 216). Univariable analysis showed that gender, level of education, and DESS and BRS scores correlated significantly (P <.05) with MBI scores. Adjusted multiple linear regression lends further support to that the MBI scores negatively correlated with the BRS score but positively correlated with the DESS score (β = -0.29, P <.001; β = 0.44, P <.001, respectively). Within the limitations of this study, the findings demonstrated that increases in resilience correlated significantly with decreases in burnout and increases in environmental stress correlated significantly with increases in burnout among dental students. However, gender had no influence on burnout

Rupture characteristics of a small-sized earthquake (M W 4.2), onshore the south Red Sea, Saudi Arabia

The present study is based on the use of Empirical Green's Function (EGF) deconvolution technique to retrieve the slip distribution of the 2014 M w 4.2 Jizan earthquake, Saudi Arabia. Two datasets of complex Source Time Functions (STFs) were retrieved using two appropriate EGF events. We inverted the STF datasets to recover the slip distribution over both nodal planes, using the Bayesian modeling followed by a linear least-squares method. The inversion was performed assuming both planes as the fault plane and examined the goodness of fit for each nodal plane. Based on a series of finite-source inversions using different rupture velocities, we resolved the rupture velocity at 2.7–2.8 km/s and the fault plane of NNW trending; paralleling the Red Sea rift. Using the estimated rupture velocities and the preferred fault plane, we imaged quite similar slip models, exhibiting two slip patches located to the updip and downdip directions from the hypocentre. The spatiotemporal slip distributions revealed a complex rupture history of such small-sized earthquake is likely to that reported for large-sized earthquakes. A seismic moment of 2.8–3.2E+15 NM and a corresponding moment magnitude of 4.2-4-3 are inferred. The stress drops obtained from the slip distribution models were 2.2–2.5 MPa; indicating a typical value that characterized the plate-boundary earthquakes

Reframing Perceptions in Restorative Dentistry:Evidence-Based Dentistry and Clinical Decision-Making

OBJECTIVES: The worldwide interest of both dentists and patients in esthetic dentistry has affected decision-making in dental practice. The aim of this study was to investigate contemporary dental practice in restorative dentistry and the relationship between evidence-based dentistry in caries research and decision-making in clinical practice in restorative dentistry. METHODS: The study was conducted through a structured questionnaire distributed randomly at the Jordanian Dental Association registered dentists in Jordan. The questionnaire aimed to clarify the degree of knowledge and practice of evidence-based dentistry in caries research the dentists hold regarding clinical decision-making in restorative dentistry. RESULTS: The majority of the surveyed dentists (77%) treat teeth with irreversible pulpitis with root canal treatment rather than vital pulp therapy. 13.8% routinely insert a post and 23% routinely crown the tooth after root canal treatment regardless of the remaining tooth structure. Badly damaged teeth are treated with full crowns in 72% of the cases. Regarding Hollywood smile or smile makeover, the majority of dentists choose conservative approaches, and implants were the first choice to replace missing teeth for 93.8% of the surveyed dentists. CONCLUSION: A higher degree of implementation of evidence-based dentistry in clinical decision-making was found in Prosthetic Dentistry than in Endodontics. Yet, the gap between evidence-based data and clinical practice needs bridging. More emphasis on communicating these data to educators to integrate them into the dental curriculum is a must

Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas

Dedifferentiated endometrial carcinoma is an aggressive type of endometrial cancer that contains a mix of low-grade endometrioid and undifferentiated carcinoma components. We performed targeted sequencing of eight dedifferentiated carcinomas and identified somatic frameshift/nonsense mutations in SMARCA4, a core ATPase of the switch/sucrose non-fermenting (SWI/SNF) complex, in the undifferentiated components of four tumors. Immunohistochemical analysis confirmed the loss of SMARCA4 in the undifferentiated component of these four SMARCA4-mutated cases, whereas the corresponding low-grade endometrioid component showed retained SMARCA4 expression. An expanded survey of other members of the SWI/SNF complex showed SMARCB1 loss in the undifferentiated component of two SMARCA4-intact tumors, and all SMARCA4- or SMARCB1-deficient tumors showed concomitant loss of expression of SMARCA2. We subsequently examined the expression of SMARCA2, SMARCA4, and SMARCB1 in an additional set of 22 centrally reviewed dedifferentiated carcinomas and 31 grade 3 endometrioid carcinomas. Combining the results from the index and the expansion set, 15 of 30 (50%) of the dedifferentiated carcinomas examined showed either concurrent SMARCA4 and SMARCA2 loss (37%) or concurrent SMARCB1 and SMARCA2 loss (13%) in the undifferentiated component. The loss of SMARCA4 or SMARCB1 was mutually exclusive. All 31 grade 3 endometrioid carcinomas showed intact expression of these core SWI/SNF proteins. The majority (73%) of the SMARCA4/SMARCA2-deficient and half of SMARCB1/SMARCA2-deficient undifferentiated component developed in a mismatch repair-deficient molecular context. The observed spatial association between SWI/SNF protein loss and histologic dedifferentiation suggests that inactivation of these core SWI/SNF proteins may contribute to the development of dedifferentiated endometrial carcinoma