Notes from the Sporades, Astypalaea, Telos, Nisyros, Leros"

Preface: Dawkins R.M, Wace Alan J.B.Appendix.Dedication:Illustration: (Maps ,Views ,photographs)Pagination: 151-174Edition:1stText Genre:ProseIllustration: (χάρτες ,τοπία ,φωτογραφίες

Greek Lands and Letters.

Preface: Allinson F.G., AnneAppendix.Introduction.Dedication:Content description: IndexIllustration: (Maps ,antiquities ,varia ,)Pagination: PP17+472P+2PPVolumes: 1Text Genre:ProseIllustration: (χάρτες ,αρχαιότητες ,άλλα θέματα ,

Characterisation of soft X-ray damage in charge coupled devices

There is considerable interest in the effects of radiation damage on solid-state imagers. The characterisation of trapping centres in charge coupled device (CCD) imagers, using Deep Level Transient Spectroscopy (DLTS), is presented. The effects of UV illumination and elevated temperature annealing in a hydrogen-rich environment are also discussed

Characterisation of soft X-ray damage in charge coupled devices

There is considerable interest in the effects of radiation damage on solid-state imagers. The characterisation of trapping centres in charge coupled device (CCD) imagers, using Deep Level Transient Spectroscopy (DLTS), is presented. The effects of UV illumination and elevated temperature annealing in a hydrogen-rich environment are also discussed.</p

A comparison between monophasic and biphasic defibrillation for the cardioversion of persistent atrial fibrillation in patients with and without heart failure

Aims: Atrial fibrillation (AF) and heart failure commonly coexist. Restoring sinus rhythm using external direct current cardioversion (DCCV) may improve left ventricular function, exercise capacity and quality of life (QoL). However, DCCV may be less successful at restoring sinus rhythm in patients with heart failure. We aimed to determine whether biphasic DCCV was superior to monophasic DCCV for the restoration of sinus rhythm in patients with heart failure. Methods: 592 consecutive cardioversion procedures were performed on 503 patients for persistent AF, 261 (44%) procedures using monophasic defibrillation and 331 (56%) using biphasic. Patients with symptomatic heart failure were identified for further analysis. Results: 173 cardioversions were performed on 149 patients with heart failure. The overall success rate of cardioversion in this group was 82.7% (83.3% and 82.2% for monophasic and biphasic respectively). There was no difference in the success rate of cardioversion for those with heart failure compared to those without heart failure (p = 0.141). Furthermore, there was no substantial difference in success rates according to defibrillation type (83.3% v. 84.2% for monophasic and 82.2% v. 88.5% for biphasic, p = 0.502 and 0.085 respectively). Conclusion: External defibrillation is similarly effective at restoring SR in patients with and without HF and both mono- and biphasic shocks have a high rate of success. However, significantly less energy (maximal and cumulative) is required to restore SR using biphasic defibrillation

[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

The extent of surgical resection is significantly correlated with outcome in glioma; however, current intraoperative navigational tools are useful only in a subset of patients. We show here that a new optical intraoperative technique, Cerenkov luminescence imaging (CLI) following intravenous injection of O‑(2-[18F]fluoroethyl)-L-tyrosine (FET), can be used to accurately delineate glioma margins, performing better than the current standard of fluorescence imaging with 5-aminolevulinic acid (5-ALA). Methods: Rats implanted orthotopically with U87, F98 and C6 glioblastoma cells were injected with FET and 5-aminolevulinic acid (5-ALA). Positive and negative tumor regions on histopathology were compared with CL and fluorescence images. The capability of FET CLI and 5-ALA fluorescence imaging to detect tumor was assessed using receptor operator characteristic curves and optimal thresholds (CLIOptROC and 5-ALAOptROC) separating tumor from healthy brain tissue were determined. These thresholds were used to guide prospective tumor resections, where the presence of tumor cells in the resected material and in the remaining brain were assessed by Ki-67 staining. Results: FET CLI signal was correlated with signal in preoperative PET images (y = 1.06x - 0.01; p 92% and specificity >91%, and resulted in a more complete tumor resection. Conclusion: FET CLI can be used to accurately delineate glioblastoma tumor margins, performing better than the current standard of fluorescence imaging following 5-ALA administration, and is therefore a promising technique for clinical translation.Cancer Research U