Thrombosis in vasculitis: from pathogenesis to treatment

In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet’s syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet’syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet’s syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients

Two-way fluid-structure coupling in vibration and damping analysis of an oscillating hydrofoil

Fluid-structure interaction (FSI) and unavoidable vibrations are important characteristics in the operation of hydropower structures and must be taken into account in the analysis and design of such equipment. Hydrodynamic damping influences the amplitude of vibrations and is directly related to fatigue problems in hydraulic machines which are of great importance. The aim of this study is to investigate the coupled effects of flowing fluid on a simplified hydrofoil by using three-dimensional two-way fluid-structure interaction modeling, in order to determine its importance in predicting vibration amplitudes and damping. The effect of considering different flow velocities is also investigated in the present study. The results of this research are compared with those obtained from experiments done by ANDRITZ [1]. The influences of mesh size and time step are also studied. Our results indicate that considering FSI in predicting the frequencies of the fluctuating fluid forces in practical problems might be ignored if the main concern of the analysis is to check the possibility of resonance. However, FSI must be included in the modeling when we aim to predict the influence of the fluid on the damping behavior in the hydrofoil vibration.</jats:p

Value of magnetic resonance imaging for evaluating muscle inflammation: insights from a new mouse model of myositis

International audienc

Une solution nouvelle pour l’évaluation des myosites : la mesure de l’activité physique quotidienne par accéléromètrie

International audienc

La dermatomyosite associée à l’anticorps anti-MDA5 est une maladie saisonnière : un argument pour un facteur déclenchant viral

International audienc

Une nouvelle classification des myopathies inflammatoires idiopathiques basée sur des manifestations cliniques et les anticorps spécifiques des myosites

International audienc