Safety of localizing epilepsy monitoring intracranial electroencephalograph electrodes using MRI: radiofrequency-induced heating

Purpose: To investigate heating during postimplantation localization of intracranial electroencephalograph (EEG) electrodes by MRI. Materials and Methods: A phantom patient with a realistic arrangement of electrodes was used to simulate tissue heating during MRI. Measurements were performed using 1.5 Tesla (T) and 3T MRI scanners, using head- and body-transmit RF-coils. Two electrode-lead configurations were assessed: a standard condition with external electrode-leads physically separated and a fault condition with all lead terminations electrically shorted. Results: Using a head-transmit-receive coil and a 2.4 W/kg head-average specific absorption rate (SAR) sequence, at 1.5T the maximum temperature change remained within safe limits (<1°C). Under standard conditions, we observed greater heating (2.0°C) at 3T on one system and similar heating (<1°C) on a second, compared with the 1.5T system. In all cases these temperature maxima occurred at the grid electrode. In the fault condition, larger temperature increases were observed at both field strengths, particularly for the depth electrodes. Conversely, with a body-transmit coil at 3T significant heating (+6.4°C) was observed (same sequence, 1.2/0.5 W/kg head/body-average) at the grid electrode under standard conditions, substantially exceeding safe limits. These temperature increases neglect perfusion, a major source of heat dissipation in vivo. Conclusion: MRI for intracranial electrode localization can be performed safely at both 1.5T and 3T provided a head-transmit coil is used, electrode leads are separated, and scanner-reported SARs are limited as determined in advance for specific scanner models, RF coils and implant arrangements. Neglecting these restrictions may result in tissue injury

Feasibility of simultaneous intracranial EEG-fMRI in humans: a safety study

In epilepsy patients who have electrodes implanted in their brains as part of their pre-surgical assessment, simultaneous intracranial EEG and fMRI (icEEG-fMRI) may provide important localising information and improve understanding of the underlying neuropathology. However, patient safety during icEEG-fMRI has not been addressed. Here the potential health hazards associated with icEEG-fMRI were evaluated theoretically and the main risks identified as: mechanical forces on electrodes from transient magnetic effects, tissue heating due to interaction with the pulsed RF fields and tissue stimulation due to interactions with the switched magnetic gradient fields. These potential hazards were examined experimentally in vitro on a Siemens 3 T Trio, 1.5 T Avanto and a GE 3 T Signa Excite scanner using a Brain Products MR compatible EEG system. No electrode flexion was observed. Temperature measurements demonstrated that heating well above guideline limits can occur. However heating could be kept within safe limits (< 1.0 °C) by using a head transmit RF coil, ensuring EEG cable placement to exit the RF coil along its central z-axis, using specific EEG cable lengths and limiting MRI sequence specific absorption rates (SARs). We found that the risk of tissue damage due to RF-induced heating is low provided implant and scanner specific SAR limits are observed with a safety margin used to account for uncertainties (e.g. in scanner-reported SAR). The observed scanner gradient switching induced current (0.08 mA) and charge density (0.2 μC/cm2) were well within safety limits (0.5 mA and 30 μC/cm2, respectively). Site-specific testing and a conservative approach to safety are required to avoid the risk of adverse events

Functional MRI with active, fully implanted, deep brain stimulation systems: Safety and experimental confounds

We investigated safety issues and potential experimental confounds when performing functional magnetic resonance imaging (fMRI) investigations in human subjects with fully implanted, active, deep brain stimulation (DBS) systems. Measurements of temperature and induced voltage were performed in an in vitro arrangement simulating bilateral DBS during magnetic resonance imaging (MRI) using head transmit coils in both 1.5 and 3.0 T MRI systems. For MRI sequences typical of an fMRI study with coil-averaged specific absorption rates (SARs) less than 0.4 W/kg, no MRI-induced temperature change greater than the measurement sensitivity (0.1 °C) was detected at 1.5 T, and at 3 T temperature elevations were less than 0.5 °C, i.e. within safe limits. For the purposes of demonstration, MRI pulse sequences with SARs of 1.45 W/kg and 2.34 W/kg (at 1.5 T and 3 T, respectively) were prescribed and elicited temperature increases (> 1 °C) greater than those considered safe for human subjects. Temperature increases were independent of the presence or absence of active stimulator pulsing. At both field strengths during echo planar MRI, the perturbations of DBS equipment performance were sufficiently slight, and temperature increases sufficiently low to suggest that thermal or electromagnetically mediated experimental confounds to fMRI with DBS are unlikely. We conclude that fMRI studies performed in subjects with subcutaneously implanted DBS units can be both safe and free from DBS-specific experimental confounds. Furthermore, fMRI in subjects with fully implanted rather than externalised DBS stimulator units may offer a significant safety advantage. Further studies are required to determine the safety of MRI with DBS for other MRI systems, transmit coil configurations and DBS arrangements

Animal Agriculture in South Carolina

Livestock Production/Industries,

Animal Agriculture in South Carolina: A Fact Book

Livestock Production/Industries,

Thermal partition function of photons and gravitons in a Rindler wedge

The thermal partition function of photons in any covariant gauge and gravitons in the harmonic gauge, propagating in a Rindler wedge, are computed using a local $\zeta$-function regularization approach. The correct Planckian leading order temperature dependence $T^4$ is obtained in both cases. For the photons, the existence of a surface term giving a negative contribution to the entropy is confirmed, as earlier obtained by Kabat, but this term is shown to be gauge dependent in the four-dimensional case and, therefore is discarded. It is argued that similar terms could appear dealing with any integer spin $s\geq 1$ in the massless case and in more general manifolds. Our conjecture is checked in the case of a graviton in the harmonic gauge, where different surface terms also appear, and physically consistent results arise dropping these terms. The results are discussed in relation to the quantum corrections to the black hole entropy.Comment: 29 pages, RevTeX, no figures. Minor errors corrected and a few comments changed since first submission. To be published on Phys.Rev.

Constraining the dark energy with galaxy clusters X-ray data

The equation of state characterizing the dark energy component is constrained by combining Chandra observations of the X-ray luminosity of galaxy clusters with independent measurements of the baryonic matter density and the latest measurements of the Hubble parameter as given by the HST key project. By assuming a spatially flat scenario driven by a "quintessence" component with an equation of state $p_x = \omega \rho_x$ we place the following limits on the cosmological parameters $\omega$ and $\Omega_{\rm{m}}$: (i) $-1 \leq \omega \leq -0.55$ and $\Omega_{\rm m} = 0.32^{+0.027}_{-0.014}$ (1$\sigma$) if the equation of state of the dark energy is restricted to the interval $-1 \leq \omega < 0$ (\emph{usual} quintessence) and (ii) $\omega = -1.29^{+0.686}_{-0.792}$ and $\Omega_{\rm{m}} = 0.31^{+0.037}_{-0.034}$ ($1\sigma$) if $\omega$ violates the null energy condition and assume values $< -1$ (\emph{extended} quintessence or ``phantom'' energy). These results are in good agreement with independent studies based on supernovae observations, large-scale structure and the anisotropies of the cosmic background radiation.Comment: 6 pages, 4 figures, LaTe

Cosmic acceleration from second order gauge gravity

We construct a phenomenological theory of gravitation based on a second order gauge formulation for the Lorentz group. The model presents a long-range modification for the gravitational field leading to a cosmological model provided with an accelerated expansion at recent times. We estimate the model parameters using observational data and verify that our estimative for the age of the Universe is of the same magnitude than the one predicted by the standard model. The transition from the decelerated expansion regime to the accelerated one occurs recently (at $\sim9.3\;Gyr$).Comment: RevTex4 15 pages, 1 figure. Accepted for publication in Astrophysics & Space Scienc

Non-Fermi liquid behavior and scaling of low frequency suppression in optical conductivity spectra of CaRuO3_3

Optical conductivity spectra $\sigma_1(\omega)$ of paramagnetic CaRuO$_3$ are investigated at various temperatures. At T=10 K, it shows a non-Fermi liquid behavior of $\sigma_1(\omega)\sim 1/{\omega}^{\frac 12}$, similar to the case of a ferromagnet SrRuO$_3$. As the temperature ($T$) is increased, on the other hand, $\sigma_1(\omega)$ in the low frequency region is progressively suppressed, deviating from the 1/{\omega}^{\frac 12%}-dependence. Interestingly, the suppression of $\sigma_1(\omega)$ is found to scale with $\omega /T$ at all temperatures. The origin of the $$ scaling behavior coupled with the non-Fermi liquid behavior is discussed.Comment: 4 pages, 3 figure

Can we save large carnivores without losing large carnivore science?

Large carnivores are depicted to shape entire ecosystems through top-down processes. Studies describing these processes are often used to support interventionist wildlife management practices, including carnivore reintroduction or lethal control programs. Unfortunately, there is an increasing tendency to ignore, disregard or devalue fundamental principles of the scientific method when communicating the reliability of current evidence for the ecological roles that large carnivores may play, eroding public confidence in large carnivore science and scientists. Here, we discuss six interrelated issues that currently undermine the reliability of the available literature on the ecological roles of large carnivores: (1) the overall paucity of available data, (2) reliability of carnivore population sampling techniques, (3) general disregard for alternative hypotheses to top-down forcing, (4) lack of applied science studies, (5) frequent use of logical fallacies, and (6) generalisation of results from relatively pristine systems to those substantially altered by humans. We first describe how widespread these issues are, and given this, show, for example, that evidence for the roles of wolves (Canis lupus) and dingoes (Canis lupus dingo) in initiating trophic cascades is not as strong as is often claimed. Managers and policy makers should exercise caution when relying on this literature to inform wildlife management decisions. We emphasise the value of manipulative experiments, and discuss the role of scientific knowledge in the decision-making process. We hope that the issues we raise here prompt deeper consideration of actual evidence, leading towards an improvement in both the rigour and communication of large carnivore science