Noncontact temperature pattern measuring device

Laser pyrometer techniques are utilized to accurately image a true temperature distribution on a given target without touching the target and without knowing the localized emissivity of the target. The pyrometer utilizes a very high definition laser beam and photodetector, both having a very narrow focus. The pyrometer is mounted in a mechanism designed to permit the pyrometer to be aimed and focused at precise localized points on the target surface. The pyrometer is swept over the surface area to be imaged, temperature measurements being taken at each point of focus

The Ursinus Weekly, April 24, 1939

Experienced cast to present Far off hills on May 12-13 • Women elect Taylor, Reifsnyder and Roberts; Snyder new Y president • List of characters for \u27Tulip town\u27 announced • Advisory committee to hold vocational clinics • Funk, Barnes new presidents of campus forensic societies • Student chemists will meet on campus this Saturday • May hop will feature music of Clyde Walton and his orchestra • Love-in-a-mist completes junior week-end • Schumann concert in costume will be given Wednesday night • One hundred sixty couples dance to music by Bartha • Changes in foreign policies to be discussed by IRC • Ursinus students appointed by Cape Cod music institute • Jayvee baseballers tie Hill, lose to Perkiomen Prep • Day study again wins interdorm basketball • Bear trackmen finish second in triangular meet with Gettysburg, Drexel; Eshbach stars • Baseballers thump Dickinson Devils, 9-0https://digitalcommons.ursinus.edu/weekly/1868/thumbnail.jp

SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.

SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain interactions and has lost its canonical function to bind to methylated lysines. The structure provides new insights into the missense mutations that target this module in cancer. This study also reveals two adjacent, highly-conserved pockets in a cleft between the domains that form a potential binding site, which can be targeted with small molecules, offering a new strategy to target SWI/SNF complexes

SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.

SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain interactions and has lost its canonical function to bind to methylated lysines. The structure provides new insights into the missense mutations that target this module in cancer. This study also reveals two adjacent, highly-conserved pockets in a cleft between the domains that form a potential binding site, which can be targeted with small molecules, offering a new strategy to target SWI/SNF complexes

Casimir Invariants for Systems Undergoing Collective Motion

Dicke states are states of a collection of particles which have been under active investigation for several reasons. One reason is that the decay rates of these states can be quite different from a set of independently evolving particles. Another reason is that a particular class of these states are decoherence-free or noiseless with respect to a set of errors. These noiseless states, or more generally subsystems, can avoid certain types of errors in quantum information processing devices. Here we provide a method for calculating invariants of systems of particles undergoing collective motions. These invariants can be used to determine a complete set of commuting observables for a class of Dicke states as well as identify possible logical operations for decoherence-free/noiseless subsystems. Our method is quite general and provides results for cases where the constituent particles have more than two internal states.Comment: 5 page

Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic obstructive pulmonary disease in a practice setting

Umair Gauhar, Mark Dransfield, J Allen D CooperPulmonary Section, Birmingham Veterans Affairs Medical Center and Division of Allergy, Pulmonary and Critical Medicine University of Alabama at Birmingham, AL, USAObjective: To determine the effect of changing anticholinergic therapy in patients with COPD from ipratropium to tiotropium on pulmonary function.Methods: We examined records of patients prescribed high-dose ipratropium, who were subsequently converted to tiotropium. Spirometric values were obtained within 2 days of the change in medication and after 56 to 224 days of the switch to tiotropium.Results: 15 subjects were documented to have filled a prescription for ipratropium-containing medications the month prior to the change. Medication compliance over the 6 months prior to the switch in these patients was 72% ± 31% (mean ± SD) for ipratropium compared to 87% ± 14% for tiotropium over the 6-month period after the switch (P = 0.1). FEV1 improved from 1.12 ± 0.39 L at baseline to 1.37 ± 0.49 L after the change to tiotropium (P = 0.01). FVC also improved from 2.45 ± 0.73 L at baseline to 2.72 ± 0.69 L after the change (P = 0.04). Maximal voluntary ventilation was also increased from 39.67 ± 10.7 L/min to 45.13 ± 15.8 L/min (P = 0.045).Conclusions: We conclude that replacing high-dose ipratropium with tiotropium therapy significantly improves pulmonary function in a clinical setting.Keywords: ipratropium, tiotropium, COPD, pulmonary function, exacerbation rat

Exit plane H2O concentration measurements correlated with OH PLIF near-injector mixing measurements for scramjet flows

Mixing and combusting high enthalpy flows, similar to those encountered in scramjet engines, were investigated using a shock tunnel to produce the flow in conjunction with non-intrusive optical diagnostics which monitored the performance of two injector configurations. The shock tunnel is configured to produce Mach 3 flow and stagnation enthalpies corresponding to flight equivalent Mach numbers between 7 and 11. A pulsed hydrogen injection capability and interchangeable injector blocks provide a means of examining high speed, high enthalpy reacting flows. Planar laser induced fluorescence (PLIF) of OH molecules in the near injector region produced images which show the combusting and mixing zones for the reacting flow. Line-of-sight exit plane measurement of water concentration and temperature were used to provide a unique method of monitoring exit plane products. These results demonstrated that a velocity matched axial injection system produced a fuel jet that lifted off the floor of the duct. Mixing was observed to increase for this system as a velocity mismatch was introduced. Comparison of exit plane water concentrations for a wall jet injection system and a velocity matched injection system indicated similar mixing performance but an accurate pressure measurement is necessary to further validate the result. In addition, exit plane measurements indicated an approximate steady-state condition was achieved during the 1 to 2 ms test times

A high-resolution structure of the EF-hand domain of human polycystin-2.

Autosomal dominant polycystic kidney disease (ADPKD) affects over 1:1000 of the worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 encodes a 968-amino acid membrane spanning protein, Polycystin-2 (PC-2), which is a member of the TRP ion channel family. The C-terminal cytoplasmic tail contains an EF-hand motif followed by a short coiled-coil domain. We have determined the structure of the EF-hand region of PC-2 using NMR spectroscopy. The use of different boundaries, compared with those used in previous studies, have enabled us to determine a high resolution structure and show that the EF hand motif forms a standard calcium-binding pocket. The affinity of this pocket for calcium has been measured and mutants that both decrease and increase its affinity for the metal ion have been created

Increasing On-Task Behavior Using Teacher Attention Delivered on a Fixed-Time Schedule

The effectiveness of fixed-time delivery of attention to increase the on-task behavior of 2 students in general education was examined. The teacher in this study provided attention to students on a 5-min fixed-time schedule and responded to students in her typical manner between cued intervals. An ABAB withdrawal design was used to test the effects of the intervention. The results of this study indicate that a fixed-time schedule of attention was effective in increasing students’ on-task behavior and decreasing their off-task behavior. Implications of the study for research and practice are discussed

Large Angular Scale CMB Anisotropy Induced by Cosmic Strings

We simulate the anisotropy in the cosmic microwave background (CMB) induced by cosmic strings. By numerically evolving a network of cosmic strings we generate full-sky CMB temperature anisotropy maps. Based on $192$ maps, we compute the anisotropy power spectrum for multipole moments $\ell \le 20$. By comparing with the observed temperature anisotropy, we set the normalization for the cosmic string mass-per-unit-length $\mu$, obtaining $G\mu/c^2=1.05 {}^{+0.35}_{-0.20} \times10^{-6}$, which is consistent with all other observational constraints on cosmic strings. We demonstrate that the anisotropy pattern is consistent with a Gaussian random field on large angular scales.Comment: 4 pages, RevTeX, two postscript files, also available at http://www.damtp.cam.ac.uk/user/defects/ to appear in Physical Review Letters, 23 September 199