433 research outputs found
Review on possible gravitational anomalies
This is an updated introductory review of 2 possible gravitational anomalies
that has attracted part of the Scientific community: the Allais effect that
occur during solar eclipses, and the Pioneer 10 spacecraft anomaly,
experimented also by Pioneer 11 and Ulysses spacecrafts. It seems that, to
date, no satisfactory conventional explanation exist to these phenomena, and
this suggests that possible new physics will be needed to account for them. The
main purpose of this review is to announce 3 other new measurements that will
be carried on during the 2005 solar eclipses in Panama and Colombia (Apr. 8)
and in Portugal (Oct.15).Comment: Published in 'Journal of Physics: Conferences Series of the American
Institute of Physics'. Contribution for the VI Mexican School on Gravitation
and Mathematical Physics "Approaches to Quantum Gravity" (Playa del Carmen,
Quintana Roo, Mexico, Nov. 21-27, 2004). Updates to this information will be
posted in http://www.lsc-group.phys.uwm.edu/~xavier.amador/anomalies.htm
Self-medication for migraine: a Nationwide cross-sectional study in Italy
Headache disorders are considered the second leading cause of years lived with disability worldwide, and 90% of people have a headache episode at least once a year, thus representing a relevant public health priority. As the pharmacist is often the first and only point of reference for people complaining of headache, we carried out a survey in a nationwide sample of Italian pharmacies, in order to describe the distribution of migraine or non-migraine type headaches and medicines overuse among people entering pharmacies seeking for self-medication; and to evaluate the association, in particular of migraine, with socio-demographic and clinical characteristics, and with the pathway of care followed by the patients. A 14-item questionnaire, including socio-demographic and clinical factors, was administered by trained pharmacists to subjects who entered a pharmacy requesting self-medication for a headache attack. The ID Migraine™ Screener was used to classify headache sufferers in four classes. From June 2016 to January 2017, 4424 people have been interviewed. The prevalence of definite migraines was 40%, significantly higher among women and less educated people. About half of all headache sufferers and a third of migraineurs do not consider their condition as a disease and are not cared by any doctor. Among people seeking self-medication in pharmacies for acute headache attacks, the rate of definite or probable migraine is high, and a large percentage of them is not correctly diagnosed and treated. The pharmacy can be a valuable observatory for the study of headaches, and the first important step to improve the quality of care delivered to these patients
Narrative Medicine to integrate patients’, caregivers’ and clinicians’ migraine experiences: the DRONE multicentre project
Background: Although migraine is widespread and disabling, stigmatisation and poor awareness of the condition still represent barriers to effective care; furthermore, research on migraine individual and social impact must be enhanced to unveil neglected issues, such as caregiving burden. The project investigated the migraine illness experience through Narrative Medicine (NM) to understand daily life, needs and personal resources of migraneurs, their caregivers and clinicians, and to provide insights for clinical practice. Methods: The project involved 13 Italian headache centres and targeted migraneurs, their caregivers and migraine specialists at these centres. Written narratives, composed by a sociodemographic survey and illness plot or parallel chart, were collected through the project’s webpage. Illness plots and parallel charts employed open words to encourage participants’ expression. Narratives were analysed through Nvivo software, interpretive coding and NM classifications. Results: One hundred and seven narratives were collected from patients and 26 from caregivers, as well as 45 parallel charts from clinicians. The analysis revealed migraine perception in social, domestic and work life within the care pathway evolution and a bond between chaos narratives and day loss due to migraine; furthermore, narratives suggested the extent of the caregiving burden and a risk of underestimation of migraine burden in patients’ and caregivers’ life. Conclusion: The project represents the first investigation on migraine illness experience through NM simultaneously considering migraneurs’, caregivers’ and clinicians’ perspectives. Comparing narratives and parallel charts allowed to obtain suggestions for clinical practice, while NM emerged as able to foster the pursuing of migraine knowledge and awareness
On higher derivative gravity, c-theorems and cosmology
We consider higher derivative gravity lagrangians in 3 and 4 dimensions,
which admit simple c-theorems, including upto six derivative curvature
invariants. Following a suggestion by Myers, these lagrangians are restricted
such that the fluctuations around (anti) de Sitter spaces have second order
linearized equations of motion. We study c-theorems both in the context of
AdS/CFT and cosmology. In the context of cosmology, the monotonic function is
the entropy defined on the apparent horizon through Wald's formula. Exact black
hole solutions which are asymptotically (anti) de Sitter are presented. An
interesting lower bound for entropy is found in de Sitter space. Some aspects
of cosmology in both D=3 and D=4 are discussed.Comment: 23 pages, v3: clarifications added, references adde
Joint Metabonomic and Instrumental Analysis for the Classification of Migraine Patients with 677-MTHFR Mutations
Migraine is a neurological disorder that correlates with an increased risk of cerebrovascular lesions. Genetic mutations of the MTHFR gene are correlated to migraine and to the increased risk of artery pathologies. Also, migraine patients show altered hematochemical parameters, linked to an impaired platelet aggregation mechanism. Hence, the vascular assessment of migraineurs is of primary importance
Determinant and Weyl anomaly of Dirac operator: a holographic derivation
We present a holographic formula relating functional determinants: the
fermion determinant in the one-loop effective action of bulk spinors in an
asymptotically locally AdS background, and the determinant of the two-point
function of the dual operator at the conformal boundary. The formula originates
from AdS/CFT heuristics that map a quantum contribution in the bulk partition
function to a subleading large-N contribution in the boundary partition
function. We use this holographic picture to address questions in spectral
theory and conformal geometry. As an instance, we compute the type-A Weyl
anomaly and the determinant of the iterated Dirac operator on round spheres,
express the latter in terms of Barnes' multiple gamma function and gain insight
into a conjecture by B\"ar and Schopka.Comment: 11 pages; new comments and references added, typos correcte
The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice
The inflammatory cytokine TNF-alpha is a central mediator in many immune-mediated diseases, such as Crohn's disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor in these TNF-dependent diseases. We exposed TNF Delta ARE mice; in which a systemic TNF-alpha overexpression leads to the development of inflammation; to 2 or 4 weeks of air or CS. We investigated the effect of deregulated TNF expression on CS-induced pulmonary inflammation and the effect of CS exposure on the initiation and progression of gut and joint inflammation. Upon 2 weeks of CS exposure, inflammation in lungs of TNF Delta ARE mice was significantly aggravated. However, upon 4 weeks of CS-exposure, this aggravation was no longer observed. TNF Delta ARE mice have no increases in CD4+ and CD8+ T cells and a diminished neutrophil response in the lungs after 4 weeks of CS exposure. In the gut and joints of TNF Delta ARE mice, 2 or 4 weeks of CS exposure did not modulate the development of inflammation. In conclusion, CS exposure does not modulate gut and joint inflammation in TNF Delta ARE mice. The lung responses towards CS in TNF Delta ARE mice however depend on the duration of CS exposure
Entanglement Entropy from a Holographic Viewpoint
The entanglement entropy has been historically studied by many authors in
order to obtain quantum mechanical interpretations of the gravitational
entropy. The discovery of AdS/CFT correspondence leads to the idea of
holographic entanglement entropy, which is a clear solution to this important
problem in gravity. In this article, we would like to give a quick survey of
recent progresses on the holographic entanglement entropy. We focus on its
gravitational aspects, so that it is comprehensible to those who are familiar
with general relativity and basics of quantum field theory.Comment: Latex, 30 pages, invited review for Classical and Quantum Gravity,
minor correction
Thermal quenches in N=2* plasmas
We exploit gauge/gravity duality to study `thermal quenches' in a plasma of
the strongly coupled N=2* gauge theory. Specifically, we consider the response
of an initial thermal equilibrium state of the theory under variations of the
bosonic or fermionic mass, to leading order in m/T<<1. When the masses are made
to vary in time, novel new counterterms must be introduced to renormalize the
boundary theory. We consider transitions the conformal super-Yang-Mills theory
to the mass deformed gauge theory and also the reverse transitions. By
construction, these transitions are controlled by a characteristic time scale
\calt and we show how the response of the system depends on the ratio of this
time scale to the thermal time scale 1/T. The response shows interesting
scaling behaviour both in the limit of fast quenches with T\calt<<1 and slow
quenches with T\calt>>1. In the limit that T\calt\to\infty, we observe the
expected adiabatic response. For fast quenches, the relaxation to the final
equilibrium is controlled by the lowest quasinormal mode of the bulk scalar
dual to the quenched operator. For slow quenches, the system relaxes with a
(nearly) adiabatic response that is governed entirely by the late time profile
of the mass. We describe new renormalization scheme ambiguities in defining
gauge invariant observables for the theory with time dependant couplings.Comment: 78 pages, 17 figure
Holographic c-theorems in arbitrary dimensions
We re-examine holographic versions of the c-theorem and entanglement entropy
in the context of higher curvature gravity and the AdS/CFT correspondence. We
select the gravity theories by tuning the gravitational couplings to eliminate
non-unitary operators in the boundary theory and demonstrate that all of these
theories obey a holographic c-theorem. In cases where the dual CFT is
even-dimensional, we show that the quantity that flows is the central charge
associated with the A-type trace anomaly. Here, unlike in conventional
holographic constructions with Einstein gravity, we are able to distinguish
this quantity from other central charges or the leading coefficient in the
entropy density of a thermal bath. In general, we are also able to identify
this quantity with the coefficient of a universal contribution to the
entanglement entropy in a particular construction. Our results suggest that
these coefficients appearing in entanglement entropy play the role of central
charges in odd-dimensional CFT's. We conjecture a new c-theorem on the space of
odd-dimensional field theories, which extends Cardy's proposal for even
dimensions. Beyond holography, we were able to show that for any
even-dimensional CFT, the universal coefficient appearing the entanglement
entropy which we calculate is precisely the A-type central charge.Comment: 62 pages, 4 figures, few typo's correcte
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