Penerapan Metode Pembelajaran Pesawat Masalah untuk Meningkatkan Aktivitas dan Hasil Belajar Peserta Didik pada Pokok Bahasan Kelarutan dan Hasil Kali Kelarutan di Kelas XI Mia 2 SMA Islam As-shofa Pekanbaru

This is a classroom action research. This research is an attempt to improve student learning activities in chemistry on class XI MIA 2 SMA Islam As-Shofa Pekanbaru by using learning method plane problem. Student learning activity which is repaired the activity of making questions, working on plane problem, group discussion, submit answers or opinions, and enthusiastic about the game of plane problem. This research consisted of two cycles. Each cycle consisted of two meetings that went through four stages of implementation: planning, action, observation, and reflection. The collecting data used observation and test. The analysis data was describ with descriptively by using percentage technique. Based on the results obtained, it can be concluded the using of learning method plane problem can improve the activity and student learning outcomes. It can be seen by the improvement of student\u27s learning activity from 62,41% at the first cycle to 76,38% at the second cycle, and learning completeness from 68,96% at the first cycle to 82,75% at the second cycle

AN ANALYSIS OF FEATURES AND FUNCTIONS IN WOMEN’S SPEECH IN THE TALKSHOW UNITED STATES OF WOMEN SUMMIT

AbstractThis study aims at denoting the features of female speech and its functions that Michelle Obama applied in the Talk Show United States of Women Summit. In addition, the purpose of this study is to also denote the features of male speech, so as to see which feature is the most dominant in use. The study results in the finding of 18 data of women's utterances. There are 7 types of speech features consisting of 2 data adjectives, 1 datum of tag question, 2 data of raising intonations on declaratives, 1 datum of avoidance of strong swear words, 6 data of emphatic stress, 2 data of lexical hedges and 3 data of intensifiers. The female speech features in the analysis serve as hedges device and booster device. The present writer also sees that Michelle uses two types of male speech features in 4 data, they are 3 pieces of minimal responses and 1 command and directive. Therefore, it can be said that the use of female speech features in this research are more dominant than male's.Keywords: men’s speech features, women’s speech features, functions of women’s speech features

CD4 and CD8 counts of Bacillus Calmette Guerin (BCG) vaccinated neonates in parts of Edo and Delta States, Nigeria

This study examines the cellular immune factors responsible for combating infections by assessing CD4 and CD8 counts of neonates (pre and post BCG vaccination). A total of 373 blood samples were collected from neonates that visited the immunization clinics at Irrua Specialist Teaching Hospital (ISTH), Irrua and Federal Medical Centre (FMC), Asaba, Nigeria. CD4 and CD8 easy count kit (Partec, Germany) was used for the determination of CD4 and CD8  count respectively, while the samples were analysed using SL-blue Cyflow. At ISTH Irrua, 191 samples were analyzed (130:60; pre and post vaccination), while at Asaba, 182 samples were analysed (120:62; pre and post vaccination). The results showed that CD4 count was significantly higher for Pre vaccination than Post vaccination at both locations. At FMC Asaba, the CD4 count for females was significantly higher than in males (pre-BCG vaccination), while CD4 count was not significantly affected by gender at Irrua, ISTH. CD8 increases in both locations but was not significantly affected by gender. The findings of this study therefore suggests that there is a cell mediated immune response to BCG vaccine by both the male and female neonates and this is associated with a decrease in CD4 count (post vaccination).Keywords: Edo, Delta, Male, Female, Neonates, BCG, CD4, CD

Examining the immunoepigenetic-gut microbiome axis in the context of self-esteem among Native Hawaiians and other Pacific Islanders

Introduction: Native Hawaiian and other Pacific Islander (NHPI) populations experience higher rates of immunometabolic diseases compared to other racial-ethnic groups in Hawaii. As annual NHPI mortality rates for suicide and type 2 diabetes mellitus (T2DM) exceed those of the state as a whole, understanding the social and biological mechanisms underlying these disparities are urgently needed to enable preventive strategies.Methods: A community-based approach was used to investigate the immunoepigenetic-gut microbiome axis in an NHPI-enriched cohort of Oahu residents (N = 68). Self-esteem (SE) data was collected using a modified Rosenberg self-esteem (SE) assessment as a proxy measure for mental wellbeing in consideration for cultural competency. T2DM status was evaluated using point-of-care A1c (%) tests. Stool samples were collected for 16s-based metagenomic sequencing analyses. Plasma from blood samples were isolated by density-gradient centrifugation. Peripheral blood mononuclear cells (PBMCs) were collected from the same samples and enriched for monocytes using negative selection techniques. Flow-cytometry was used for immunoprofiling assays. Monocyte DNA was extracted for Illumina EPIC array-based methylation analysis.Results: Compared to individuals with normal SE (NSE), those with low SE (LSE) exhibited significantly higher plasma concentrations (pg/ml) of proinflammatory cytokines IL-8 (p = 0.051) and TNF-α (p = 0.011). Metagenomic analysis revealed that the relative abundance (%) of specific gut bacteria significantly differed between SE groups - some of which directly correlated with SE scores. Gene ontology analysis revealed that 104 significantly differentially methylated loci (DML) between SE groups were preferentially located at genes involved in immunometabolic processes. Horvath clock analyses indicated epigenetic age (Epi-Age) deceleration in individuals with LSE and acceleration in individuals with NSE (p = 0.042), yet was not reproduced by other clocks.Discussion: These data reveal novel differences in the immunoepigenetic-gut microbiome axis with respect to SE, warranting further investigation into its relationship to brain activity and mental health in NHPI. Unexpected results from Epi-Age analyses warrant further investigation into the relationship between biological age and disparate health outcomes among the NHPI population. The modifiable component of epigenetic processes and the gut microbiome makes this axis an attractive target for potential therapeutics, biomarker discovery, and novel prevention strategies

Using E-Module in Guidance Lessons to Enhance Multicultural Self-Efficacy of Islamic and Public High School Students

The implication of multiculturally Islamic and public high schools for guidance and counseling was how to help students enhance multicultural self-efficacy using self-learning electronic based-materials. The current study examined the effect of using an e-module of guidance lessons on students' multicultural self-efficacy. It constituted 10th graders of an Islamic High School (IHS) and a Public High School (PHS) as its samples. A Multicultural Self-Efficacy Scale (MSES) was employed to measure students' multicultural self-efficacy before and after completing the self-instruction of the guidance lesson comprising five units of an e-module. The study analyzed the data sets employing a paired sample t-test, independent t-tests, and N-gain techniques to test the hypotheses. The results revealed the significant effect of using the e-module on the multicultural self-efficacy of Islamic and public high school students, no significant differences between the multicultural self-efficacy of IHS and PBS students, and the value of using the e-module was at a moderate level for both groups. In conclusion, using the e-module could provide a functional account of guidance lessons to increase multicultural self-efficacy among students of IHS and PHS