CLINICAL EVALUATION OF VOICE IN CHILDREN WITH DYSPHONIA

Objective: make a comparative analysis of the voice of the index (VHI) and endoscopic studies in the pathology of the voice of children.Material and Methods: The study involved 87 children, from 6 months to 14 years. The clinical study included fibrorinolaryngoscopy with video fixation (C-MAC, K. Storz, Ø-2,7 mm) and a survey of parents (or guardians) of children at the Uzbek version of the voice handicap index (pVHI), with sub- sections (functional - F, the physical - P and emotional - E).Results: endoscopic diagnosed laryngitis 20,6% (n = 18), functional 16,1% (n = 14) and mutational 9,2% (n = 8), dysphonia, benign larynx (respiratory papillamatosis) - 18.4 % (n = 16), the vocal cords paresis - 5.7% (n = 5), the vocal folds nodules 26.4% (n = 23), throat structure anomalies (acquired) 3,4% (n = 3). The survey revealed pVHI average points total pVHI and its sub-group of patients were as follows: F - 13,94, P - 15.48, E - 12.15 and T - 41.58, which is significantly higher than the group of healthy children and children with functional disorders of voice.Conclusions: Fibrolaryngoscopy with the smallest diameter of the lumen of the laryngoscope with video fixation allowed to quickly ascertain the diagnosis of organic disease of the larynx in children. In addition, the survey pVHI allowed to differentiate the severity of the vocal apparatus, to conduct timely special endoscopic diagnosis of vocal cord diseases.Objective: make a comparative analysis of the voice of the index (VHI) and endoscopic studies in the pathology of the voice of children.Material and Methods: The study involved 87 children, from 6 months to 14 years. The clinical study included fibrorinolaryngoscopy with video fixation (C-MAC, K. Storz, Ø-2,7 mm) and a survey of parents (or guardians) of children at the Uzbek version of the voice handicap index (pVHI), with sub- sections (functional - F, the physical - P and emotional - E).Results: endoscopic diagnosed laryngitis 20,6% (n = 18), functional 16,1% (n = 14) and mutational 9,2% (n = 8), dysphonia, benign larynx (respiratory papillamatosis) - 18.4 % (n = 16), the vocal cords paresis - 5.7% (n = 5), the vocal folds nodules 26.4% (n = 23), throat structure anomalies (acquired) 3,4% (n = 3). The survey revealed pVHI average points total pVHI and its sub-group of patients were as follows: F - 13,94, P - 15.48, E - 12.15 and T - 41.58, which is significantly higher than the group of healthy children and children with functional disorders of voice.Conclusions: Fibrolaryngoscopy with the smallest diameter of the lumen of the laryngoscope with video fixation allowed to quickly ascertain the diagnosis of organic disease of the larynx in children. In addition, the survey pVHI allowed to differentiate the severity of the vocal apparatus, to conduct timely special endoscopic diagnosis of vocal cord diseases

Efficiency of modern correction methods of ovarian hyperandrogenism in puberty

Aim. To evaluate the effectiveness of correction of the ovarian hyperandrogenism (OHA) in girls in puberty. Methods. 38 girls with OHA syndrome were examined. The average age of the girls was 14.39 ± 0.27 years. Ferriman-Gallwey hirsutism score was 19.7 ± 0.47, the hormonal score 18.14 ± 2.43, the indifferent score 2.34 ± 0.13. The comparison group included 20 girls matched by age (14.74 ± 0.15 years) with physiological course of puberty. The study included the evaluation of hirsutism severity by Ferriman-Gallway score, determination of the hormones of hypothalamus-pituitary-adrenal-ovarian system in early follicular phase on day 5-7 of menstrual cycle. Results. The causes of OHA syndrome in the pubertal period were found to be polycystic ovary syndrome in 68.42 % and tumor-like formations (follicular cysts) in 31.58 % of girls. Compared to healthy girls, the girls with OHA syndrome had statistically significantly higher values of luteinizing hormone (LH) - 9.19 ± 0.96 mME/ml, LH/FSH ratio - 1.8 ± 0.15, total testosteron (Ttotal) - 1.3 ± 0.11 ng/ml, estrone (E1) - 109.5 ± 4.88 ng/ml, androstenedione (An) - 4.01 ± 0.12 ng/ml as well as low values of estradiol (E2) - 49.1 ± 2.6 pg/ml and sex hormone-binding globulin (SHBG) - 45.7 ± 2.14 nmol/l. The study demonstrated that correction of ovarian hyperandrogenism, promotes an increase in the level of E2, SHBG and decrease of the level of LH, LH/FSH ratio, Ttotal, An. Conclusion. Complex pathogenetic therapy of OHA syndrome in girls in puberty leads to significant improvement of hormonal status in this group of patients

INVESTIGATION OF MECHANICAL PROPERTIES AND CORROSION RESISTANCE OF TUBING WITH FERRITO-PERLITE STRUCTURE

Проведены исследования механических свойств и стойкости к углекислотной коррозии образцов насосно-компрессорных труб из стали 35ХГФ с феррито-перлитной структурой. Определены границы применения стали с феррито-перлитной структурой в зависимости от агрессивности среды.The carried out researches of mechanical properties and resistance to carbon dioxide corrosion of samples of tubing from steel with ferrite-pearlitic mine. The boundaries of the use of steel with a ferrite-pearlite operation are determined depending on the aggressiveness of the medium

Empirical evaluation of state support measures for the agricultural industry in modern practice

The article presents the results of the study of the effectiveness of the state program “Development of Agriculture” in the Kaliningrad region; econometric analysis of the dependence of the results of the economic activity of agricultural enterprises on the amount of state subsidy is proposed as a research method; on the basis of the econometric models the regression-correlation analysis of the effectiveness of financial resources distribution on the main directions of the state agricultural program is conducted

Immediate and late follow-up results of auto- and alloplastic operations in inguinal hernias

Objective. To conduct a scientific investigation for comparative investigation of results of auto- and allohernioplastic operations. Materials and methods. The investigation was based on analysis of postoperative results in 400 patients, ageing 16 - 85 yrs old, to whom in Scientific Surgical Centre named after Acad. M. A. Topchibashev and the City of Shirvan Central Hospital in 2009-2019 yrs period surgical treatment for inguinal hernia was conducted. Depending on the procedure of hernioplasty applied, the patients were divided into two Groups. In a control one (n=200) the operations were performed, using open autohernioplasty only. In the main Group (n=200) open procedure and laparoscopic allohernioplasty, using different synthetic nets, were applied. Results. Comparative analysis of intraoperative, postoperative immediate and late follow-up results in the patients after auto- and allohernioplasty was done. In accordance to criteria of the intraoperative and immediate postoperative morbidity rate the statistically meaningful differences between two groups of patients were absent. Good late results of allohernioplasty were noted in (71.8 ± 3.41)%, satisfactory - in (17.2 ± 2.86)%, poor - in (11 ± 2.36)% patients (p<0.05); allohernioplasties - accordingly, in (80.2 ± 2.91)%, (16 ± 2.68)% and (3.8 ± 1.39)% patients (p<0.05). Comparative analysis done have shown the statistically much better results of allohernioplasty. Recurrences after allohernioplasty were observed in 3 times less frequently - 3.8%, and after autohernioplasty this index have constituted 11% (p < 0.05). Сomparative analysis of late follow-up results of various autohernioplastic methods have shown good results of Postemskyi method in (76.7 ± 7.72)% patients, and of Postempskyi method in our modification - in (88.9 ± 7.41)% patients. Good results of autoplasty in other methods were noted merely in equal quantity of the patients - in up to 70%, and statistically significant difference was absent. Conclusion. Basing on own results obtained, we recommend to perform autohernioplasty of the inguinal channel anterior wall in accordance to Girard-Sposokukotskyi method with Kimbarovskyi suture for oblique inguinal hernias, while in direct inguinal hernias, for strengthening of posterior wall, - Postempskyi method in our modification. In large and recurrent hernias in patients of middle and senile age it is expedient to apply a Lichtenstein plasty in our modification. Total extraperitoneal or transabdominal preperitoneal plasty is recommended if technical installments needed and the physician’n laparoscopic skills are available

Integrated solution for patients of a very high cardiovascular risk. Final results

Secondary prevention should be actively implemented at all stages of treatment and rehabilitation of patients after acute coronary syndrome (ACS). The integration of remote monitoring of patients with the transfer of vital and laboratory data into clinical practice seems promising.Aim. To evaluate the clinical and patient-centered effectiveness of the original 12-month combined face-to-face and telecare program in patients with recent ACS.Material and methods. For the present analysis the data from 84 (out of 100) patients (median age, 56 (50;61) years, 70 males) was used. These patients had to have hypertension and/or type 2 diabetes and an ACS with percutaneous revascularization within 12 months. Their low-density lipoprotein cholesterol (LDL-C) had to be above 2,4 mmol/L. Telehealth program supplemented routine care. A program contained electronic self-control diaries for blood pressure (BP) and lipid profile, and teleconsulting service (text chat). Mandatory face-to-face visits were carried out at 3 and 12 months after the enrollment. The primary end point was ∆LDL-C. Additional clinical and patient-specific endpoints were evaluated.Results. At the 12-month visit, there was a significant decrease in LDL-C by 1,6 (-2,3;-0,9) mmol/L. Besides the initial LDL-C value, the decrease in LDL-C was associated with the proper adherence to keeping diaries of BP and lipid profile (β=0,7), and the number of text messages sent by the doctor in the 1st month after the enrollment (β=0,04). In more adherent patients, the ∆LDL-C was greater by 0,49 mmol/L (95% CI (-1,2; -0,1)) after adjustment for abovementioned covariates. In 35 patients (42%), target LDL-C was achieved, in 60 patients (71%) — a decrease ≥1 mmol/l. Other lipids also have changed for the better. Moreover, adherent patients were twice as likely to achieve the target LDL-C (OR 2,2; 95% CI (0,6; 3,8)) than non-adherent ones. A decrease in office systolic BP by 5,8 mm Hg was shown (p=0,03). The number of physician-to-patient messages exceeded those from patients to physician (median 143 and 111 per patient for 12 months, respectively). The quality of life has improved, but only in terms of emotions. Satisfaction with the program remained high at all timepoints of the study.Conclusion. Our study showed the effectiveness of the integrated care in ACS patients with the telehealth tool included. Commitment to BP self-monitoring, as well as active consultative support at the first stages of rehabilitation, contributes to additional dynamic control of lipid profile, timely correction of lipid-lowering therapy with the achievement of the target LDL-C level. Most of the patients did not experience any difficulties in using the program and are ready to recommend integrated approach to other peers

Computational optical sensing and imaging 2021: feature issue introduction

This Feature Issue includes 2 reviews and 34 research articles that highlight recent works in the field of Computational Optical Sensing and Imaging. Many of the works were presented at the 2021 OSA Topical Meeting on Computational Optical Sensing and Imaging, held virtually from July 19 to July 23, 2021. Articles in the feature issue cover a broad scope of computational imaging topics, such as microscopy, 3D imaging, phase retrieval, non-line-of-sight imaging, imaging through scattering media, ghost imaging, compressed sensing, and applications with new types of sensors. Deep learning approaches for computational imaging and sensing are also a focus of this feature issue

Interplay of unsteady aerodynamics and flight dynamics of transport aircraft in icing conditions

Airframe icing causes significant degradation of aerodynamic characteristics and influences the flight safety. Wind tunnel study of longitudinal steady and unsteady aerodynamic characteristics of a transport aircraft in icing conditions is carried out in order to develop mathematical model of aerodynamics in the extended flight envelope. The wind tunnel results are validated through flight tests conducted for the real aircraft. Large, glaze-horn ice shapes, corresponding to holding flight phase, are considered. Influence of an ice protection system as well as its failure is examined. Effect of icing on the unsteady aerodynamics characteristics is studied not only through wind tunnel tests but also via analysis of subsequent influence on the flight dynamics of the aircraft. The conducted study shows that the ice shapes of the holding phase leads to reduced stall angle of attack (AoA), maximum lift, and longitudinal damping. Flight dynamics analysis demonstrates that dangerous aircraft behaviour in the form of high AoA departure and limit cycle oscillations (LCO) can be observed at smaller elevator deflections for the iced aircraft. Taking into account icing influence on the unsteady aerodynamics in the flight dynamics simulations revealed degradation of the dynamic response and deterioration of phase portraits of the system. Even for small AoA and elevator deflection the aircraft might be trapped into the basin of attraction of high-AoA LCO. In addition, incorporating icing effects in unsteady aerodynamics manifest larger amplitude of LCO