The relationship between gut microbiome estrobolome and breast cancer: A systematic review of current evidences

Breast cancer is the most frequent kind of cancer and the second leading cause of mortality worldwide, behind heart disease. Next-generation sequencing technologies enables for unprecedented enumeration of human resident gut microorganisms, conferring novel insights into the role of the microbiota in health and individuals with breast cancer. A growing body of research on microbial dysbiosis seems to indicate an elevated risk of health complications including cancer. Although several dysbiosis indices have been proposed, their underlying methodology, as well as the cohorts and conditions of breast cancer patients are significantly different. To date, these indices have not yet been thoroughly reviewed especially when it comes to researching the estrogen-gut microbiota axis. Instead of providing a thorough rating of the most effective diversity measurements, the current work aims to be used to assess the relevance of each study's findings across the demographic data, different subtypes, and stages of breast cancer, and tie them to the estrobolome, which controls the amount of oestrogen that circulates through humans. This review will cover 11 studies which will go into a detailed discussion for the microbiome results of the mentioned studies, leaving to the user the final choice of the most suited indices as well as highlight the observed bacteria found to be related to the estrobolome in hopes of giving the reader a better understanding for the biological cross-talk between gut microbiome and breast cancer progression

The relationship between gut microbiome estrobolome and breast cancer: a systematic review of current evidences

Breast cancer is the most frequent kind of cancer and the second leading cause of mortality worldwide, behind heart disease. Next-generation sequencing technologies enables for unprecedented enumeration of human resident gut microorganisms, conferring novel insights into the role of the microbiota in health and individuals with breast cancer. A growing body of research on microbial dysbiosis seems to indicate an elevated risk of health complications including cancer. Although several dysbiosis indices have been proposed, their underlying methodology, as well as the cohorts and conditions of breast cancer patients are significantly different. To date, these indices have not yet been thoroughly reviewed especially when it comes to researching the estrogen-gut microbiota axis. Instead of providing a thorough rating of the most effective diversity measurements the current work aims to be used to assess the relevance of each study’s findings across the demographic data, different subtypes, and stages of breast cancer, and tie them to the estrobolome, which controls the amount of oestrogen that circulates through humans. This review will cover 11 studies which will go into a detailed discussion for the microbiome results of the mentioned studies, leaving to the user the final choice of the most suited indices as well as highlight the observed bacteria found to be related to the estrobolome in hopes of giving the reader a better understanding for the biological cross-talk between gut microbiome and breast cancer progression

Blueprint: flexible roller conveyer / Rohana Mohd Yusof...[et al.]

A flexible roller conveyor is one of the accommodations used to move goods from one place to another. The working scope of transporting goods from one place to another is a must for those whom work in a retailer store. However, most of the small company are having limitation of space. Therefore, they created a storage at an upper space of the store. Due to the limitation of the storage space, the employees are having health issues such as back pain, neck strains, wrist sprain and etc. Therefore, most of the employees did not working with this company for a long time as the working environment is uncomfortable for them. Our objective is to ease the work of the employees as well as to save energy and time of employees. We interviewed a few of retailer store owner and discussing on producing a new product which to help them ease the work of their employees. We also conducted a market survey to know our target market opinion on this product. We discussing and brainstorming the ideas in order to enhance our product to achieve our customer's expectation. Therefore, we come out with the idea of producing a flexible roller conveyor which can be used to transport the goods from one place to a higher place. An additional feature was added as it can be used to move goods to a higher place where the height of the conveyor can be adjusted