23 research outputs found

    Initiatives for the Application of Restorative Programs in Tehran Juvenile Courts

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    The present study has answered the this question: How and on what initiative do judges provide the context for the application of restorative programs in juvenile criminal courts? Restorative interpretations of legal provisions such as referral to mediation in all Ta'zirat offenses, weakening of the constituent elements of the crime, use of the legal capacity of a conditional or suspended pardon, and obtaining the plaintiff's consent after the announcement of the end of the proceedings and before the verdict; are Judicial initiatives. Also, the replacement of similar institutions with unimpeded legal establishments such as the establishment of the Peace Council and the social work unit, the referral of mediation to counter with closed- case policy _to believe the number of closed case as the criterion for the efficiency of judicial system instead of quality of decision making_ and the cooperation with the lawyers of the Association for the Protection of Children's Rights to solve the problems caused by the undesirable quality of defense lawyers are structural initiatives to avoid obstacles

    Horizon-scale tests of gravity theories and fundamental physics from the Event Horizon Telescope image of Sagittarius A^*

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    Horizon-scale images of black holes (BHs) and their shadows have opened an unprecedented window onto tests of gravity and fundamental physics in the strong-field regime. We consider a wide range of well-motivated deviations from classical General Relativity (GR) BH solutions, and constrain them using the Event Horizon Telescope (EHT) observations of Sagittarius A^* (Sgr A^*), connecting the size of the bright ring of emission to that of the underlying BH shadow and exploiting high-precision measurements of Sgr A^*'s mass-to-distance ratio. The scenarios we consider, and whose fundamental parameters we constrain, include various regular BHs, string-inspired space-times, violations of the no-hair theorem driven by additional fields, alternative theories of gravity, novel fundamental physics frameworks, and BH mimickers including well-motivated wormhole and naked singularity space-times. We demonstrate that the EHT image of Sgr A^* places particularly stringent constraints on models predicting a shadow size larger than that of a Schwarzschild BH of a given mass, with the resulting limits in some cases surpassing cosmological ones. Our results are among the first tests of fundamental physics from the shadow of Sgr A^* and, while the latter appears to be in excellent agreement with the predictions of GR, we have shown that a number of well motivated alternative scenarios, including BH mimickers, are far from being ruled out at present.Comment: 82 pages, 47 figures, 50+ models tested. v3: fixed a few figures, clarified several points, included various analytical expressions for shadow sizes within the different models, added a few references, included a summary table (Table II). Version accepted for publication in Classical and Quantum Gravit

    Improvement of mesenchymal stem cell differentiation into the endoderm lineage by four step sequential method in biocompatible biomaterial

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    Introduction: The goal of the study described here, was to investigate the potential of umbilical cord derived mesenchymal stem cell (UC-MSCs) into hepatocyte like cells in a sequential 2D and 3D differentiation protocols as alternative therapy. Methods: Mesenchymal stem cells (MSCs) were isolated from the umbilical cord (UC) and CD markers were analyzed by flow cytometry. For hepatic differentiation of UC-MSCs, cells were induced with a sequential 4-step protocol in 3D and 2D culture system. Urea concentration and albumin secretion into the culture medium was quantified by ELISA. Gene expression levels of AFP, ALB, and CK18 were determined by RT-PCR. Data were statistically analyzed by the SPSS software. The difference between the mean was considered significant when p < 0.05. Results: Growth factor dependent morphological changes from elongated fibroblast-like cells to round epithelial cell morphology were observed in 2D culture. Cell proliferation analysis showed round-shaped morphology with clear cytoplasm and nucleus on the alginate scaffold in 3D culture. The mean valuses of albumin production and urea secretion were significantly higher in the 3D Culture system when compared with the 2D culture (p = 0.005 vs p = 0.001), respectively. Treatment of cells with TSA in the final step of differentiation induced an increased expression of CK18 and a decreased expression of αFP in both the 3D and 2D cultures (p = 0.026), but led to a decreased albumin gene expression, and an increased expression in the 2D culture (p = 0.001). Conclusion: Findings of the present study indicated that sequential exposure of UC-MSCs with growth factors in 3D culture improves hepatic differentiation
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