22 research outputs found

    Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats

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    Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically.Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group.  On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues

    Estimation of total prostate specific antigen values through artificial intelligence modelling

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    It has been indicated that total prostate specific antigen (PSA) screening, one of the serum markers used for the diagnosis of prostate cancer, has been clinically beneficial. In this research, it was aimed to estimate the total PSA values by Multilayer Perceptron (MLP) artificial neural network (ANN) model. Data on total PSA values in this study (n = 1422) were randomly selected using the structured query language (SQL) from the database of patients records of Urology Department of Medical School at Inonu University. Total PSA values as a target/dependent variable, and age (year), blood group (A/B/0/AB), Exitus (EX) status (alive/death), Lymphocyte (LY) (%), Hemoglobin (HGB) (g / dL), Neutrophil (NE) (%), Albumin (g / dL), Calcium (mg / dL), Mean Corpuscular Hemoglobin (MCH), Leukocyte count (WBC) (103 / ml), Platelet (PLT) (103/ ml) as predictor variables were evaluated in the analyses. Outlier/extreme observations were analysed, and quantitative variables were rescaled by the transformation of Z-score or Box-Cox, and the MLP ANN model was constructed to estimate the total PSA values after variable selection method was used. Estimation performance of the model was examined by the values of mean absolute error, standard deviation and correlation coefficient. The MLP ANN model was created using a total of 1422 data sets as 993 of which were in training and 429 in the testing. Values of the mean absolute error, standard deviation, and correlation coefficient were calculated for training data set as; 0.744, 0.895 and 0.452; for the test data set as; 0.773, 0.935 and 0.355. The estimated accuracy of the generated model is predicted as 20.3%. In the MLP ANN model, the importance levels of the variables were obtained as 0.33 for HGB, 0.22 for NE, 0.16 for Calcium, 0.13 for PLT, 0.10 for age and 0.06 for EX. The MLP ANN model was established for the estimation of the total PSA values based on the selected variables, and calculated the importance levels of the related variables. Better prediction results in the estimation of total PSA values can be provided by using different additional variables, various resampling methods and alternative models. [Med-Science 2018; 7(2.000): 350-4

    Pharmacopée et taxe wurtembergeoises dans l'Alsace du 18e siècle

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    Bachoffner Pierre. Pharmacopée et taxe wurtembergeoises dans l'Alsace du 18e siècle. In: Revue d'histoire de la pharmacie, 67ᵉ année, n°241, 1979. p. 118

    Deterioration of renal function in patients operated for lower urinary tract symptoms

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    Amaç: Alt üriner yol semptomu nedeniyle cerrahi tedavi uygulanan hastalarda böbrek fonksiyonlarındaki bozulma oranını ve bunun hasta yaşı, semptom ciddiyeti ve eşlik eden hastalıklarla ilişkisini belirlemeyi amaçladık. Gereç ve yöntem: Polikliniğimize 01/06/2001-31/03/2005 tarihleri arasında alt üriner sistem semptomları ile başvuran ve ameliyat edilen 369 hastanın kayıtları retrospektif olarak incelendi ve muayene bulguları ile laboratuvar sonuçları kaydedildi. Bulgular: Operasyon öncesi serum kreatinin değeri ?1.4 mg/dL olan hasta sayısı 315 (%85.4), >1.4 mg/dL olanların sayısı ise 54 (%14.6) idi. Kreatinin değeri ?1.4 mg/ dL olanların yaş ortalamaları 68.64±8.24 iken, kreatinin değeri >1.4 mg/dL olanların yaş ortalamaları 72.56±7.96 olarak bulundu (p<0.05). İlerleyen yaş ile serum kreatinin değerinin arttığı, böbrek fonksiyon bozukluğunun semptom skorundaki artış ile arttığı, hipertansiyon ve diyabet gibi kronik hastalıkların varlığında böbrek yetmezliği oranlarının 2.5 kat arttığı (%25.5’e karşılık %10.9) saptandı. İşeme sonrası rezidü idrar ile böbrek fonksiyon bozukluğu arasında ilişki saptanmadı. Ayrıca renal dilatasyonun serum kreatinin seviyesi yüksekliğine eşlik ettiği kaydedildi. Sonuç: Alt üriner yol semptomu olan hastalarda böbrek yetmezliğinin erken tanısı ve tedavisi için ilk başvuru anında böbrek fonksiyonlarını gösteren serum kreatinin seviyesine mutlaka bakılmalıdır.Objective: We aimed to investigate the rate of deterioration of the renal function in patients operated for lower urinary tract symptoms, the relation between this rate and patient age, symptom severity, and accompanying diseases. Materials and methods: The data of 369 patients who admitted to our clinic with lower urinary tract symptoms and operated between 01/06/2001 and 31/03/2005 were retrospectively evaluated, and the examination findings and laboratory results have recorded. Results: The preoperative serum creatinin level was &amp;#8804;1.4 mg/dL in 315 (85.4%) patients and &gt;1.4 mg/dL in 54 (14.6%) patients. The mean age of the patients with serum creatinin level &amp;#8804;1.4 mg/dL was 68.64&plusmn;8.24 years, and that of patients with serum creatinin level &gt;1.4 mg/dL was 72.56&plusmn;7.96 years (p&lt;0.05). The level of serum creatinin increased with increasing age, and the renal function was worsened with the increase of symptom score. Also, in the presence of the chronic diseases such as hypertension and diabetes, the rate of renal dysfunction increased by 2.5 times (25.5% vs. 10.9%). There was no correlation between postvoiding residue urine and renal dysfunction. Additionally, the renal dilatation accompanied the increase in the serum creatinin level. Conclusion: In the patients with with lower urinary tract symptoms, the serum creatinin level must be evaluated at the first admission for early diagnosis and treatment of renal dysfunction

    Accelerated atherosclerosis in haemodialysis patients; correlation of endothelial function with oxidative DNA damage

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    ALP, Hamit Hakan/0000-0002-9202-4944; Cebi, Aysegul/0000-0003-3804-7966WOS: 000301907200049PubMed: 21821836Background. Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD). The aim of this study was to evaluate the relationship between oxidative DNA damage [8-hydroxy-2'-deoxyguanosine/deoxyguanosine ratio (8-OHdG/dG ratio)], oxidative stress biomarkers and endothelial function in HD patients as an indicator of atherosclerosis. Methods. Forty-four chronic HD patients without known atherosclerotic disease and 55 age- and sex-matched healthy individuals were included in the study. Plasma malondialdehyde (MDA) levels and 8-OHdG/dG ratio were determined as oxidative stress markers. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were measured as antioxidants. Endothelial function was assessed by ultrasonography. Results. 8-OHdG/dG ratio and MDA levels were higher in HD patients than controls while SOD and GPx activities were lower in HD patients compared to controls. Flow-mediated dilatation FMD% in HD patients were lower than the control group (7.28 +/- 0.79 versus 11.18 +/- 0.82, P < 0.001). There was a significant negative correlation between FMD% and 8-OHdG/dG ratio (r = -0.678, P < 0.01) and MDA levels (r = 0.517, P < 0.01), while there was a significant positive correlation between FMD% and SOD (r = 0.538, P < 0.01) and GPx levels (r = 0.720, P < 0.01). Conclusions. Our data have demonstrated that HD patients exhibit increased oxidative DNA damage and decreased antioxidant activity. We propose that endothelial function is negatively correlated with 8-OHdG/dG ratio and positively correlated with antioxidant enzymes. To our knowledge, this is the first study to demonstrate the inverse relationship between endothelial function and plasma oxidative DNA damage in HD patients
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