Neurofibromatosis Type 1 and Diabetes Mellitus: An Unusual Association

Neurofibromatosis type 1 is a multisystemic disease. It may manifest as abnormalities of the nervous tissue, bones, soft tissue, or skin. Autoimmune disease associated with NF1 can be seen. Diabetes mellitus is rarely seen in association with NF1. Here, we report a case with established NF1 who also had a diagnosis of diabetes mellitus

Ewing's sarcoma metastasis into the breast

The metastasis of extramammary malignancies into the breast is very unusual. Lymphoma, malignant melanoma, and rhabdomyosarcoma are the most common tumors that metastasize into breast tissue. The histological spectrum of breast masses in children and adolescents is different from that of adults. Imaging findings are useful for performing a diagnosis, but in a patient with a known malignancy, any enlarging breast mass, even one with a benign radiological appearance, should be investigated with a biopsy. In this article, we present the imaging findings of a 12-year-old female patient with breast metastasis of Ewing's sarcoma

Skin and soft tissue complications in pediatric leukemia patients with and without central venous catheters

We aimed to retrospectively evaluate the skin and soft tissue complications secondary to procedures in acute leukemia patients with and without catheters. Eighty-seven acute leukemia patients (75 acute lymphoblastic leukemia, 12 acute myeloid leukemia) were included. There were 30 patients with 37 catheter use (6 port, 31 Hickman catheter) and 57 patients without catheter. In patients with catheters, skin and soft tissue complications were seen in 20 (66%) children. The most frequent complication was cellulitis (55%). In the patients without catheter, skin and soft tissue complications were seen in 37 (65%) patients. Cellulitis (37.8%) and extravasation (37.8%) were the most frequent causes. When the frequency of skin and soft tissue complications in patients with and without catheters were compared with each other, there was statistically no significant difference (P = 0.792). The duration of chemotherapy was significantly longer in patients who developed skin and soft tissue complications with or without catheters when compared with the duration of the therapy in patients without any skin and soft tissue complications (259.2 +/- 36.3 and 218.3 +/- 58.3 d, respectively; P < 0.0001). In pediatric leukemia patients, with or without catheters, skin and soft tissue complications are common and these complications may prolong the duration of chemotherapy

Delayed Renal Excretion of Methotrexate After a Severe Anaphylactic Reaction to Methotrexate in a Child With Osteosarcoma

Although methotrexate is an agent widely used in the practice of pediatric oncology, allergic reactions to methotrexate are most unusual. Most of these reactions typically occur after repeated administration. Here, we report it severe anaphylactoid reaction to the first close of high-dose methotrexate infusion in a child with osteosarcoma who has also experienced it delayed excretion of methotrexate. Clinicians must be aware of the possibility of a systemic, near-fatal anaphylactic reactions with methotrexate and patients who experience severe anaphylactic reactions should be followed carefully because of the possibility of delayed methotrexate excretion

Pilomatricoma in children: A frequently misdiagnosed superficial tumor

Pilomatricomas are the most common superficial tumors in children, but they are frequently misdiagnosed preoperatively. There are some characteristic features of pilomatricomas that can help clinicians differentiate it from other tumors. The authors report 3 children with head and neck pilomatricomas, one with multiple tumors. They emphasize some clinical features that may help in differential diagnosis to avoid unnecessary investigations before surgical removal

Outcome in Neuroblastoma

Objective To determine outcome of neuroblastoma (NBL) in children under 18 mo of age who had been treated with national protocols

Hemangiomas of Childhood: Analysis of 116 Cases

Objective: Hemangiomas are the most common benign vascular tumors of infancy. The purpose of this study was to evaluate children with hemangiomas who were followed up at our center between 2000 and 2007. Material and Methods: Medical records of children with hemangiomas were analyzed retrospectively for patient characteristics, features of hemangiomas, complications and treatments. Results: In 116 children with hemangiomas, the median age was 6 months (0-14 years), M:F ratio was 0.63. There were 113 patients with skin hemangiomas and of them 61% had solitary lesion. Head-neck hemangiomas were observed in 53% of patients. Hemangiomas were capillary (26%), cavernous (49%), or mixed (25%). The majority of patients (74%) had presented in the proliferative phase while the remaining were in the involution phase. After the initial evaluation, 42% of patients were lost to follow-up. Complications, including ulceration / bleeding (19%), infections (12%), visual (12%) and hearing (3%) compromise occurred in 34% of the 67 patients who attended the follow-up visits. Systemic corticosteroid was given in 10 patients with hemangiomas threatening vision or hearing and in 5 patients for recurrent local complications. Intralesional corticosteroid (n=4) and interferon-alpha (n=1) were administered in 5 cases in addition to corticosteroid. Surgery was performed in 3 patients. Conclusion: Infantile hemangiomas were commonly located at the head-neck region, and patients were usually admitted in the proliferative phase. The majority of patients with no indication for treatment were lost to follow-up. Treatment was necessary only in complicated hemangiomas. Corticosteroids remain the mainstay of treatment for those hemangiomas

Soft tissue sarcomas and central nervous system tumors in children with neurofibromatosis type 1.

Objects We aim to evaluate the characteristics of pediatric patients with neurofibromatosis type 1 (NF1) who developed soft tissue sarcomas (STSs) and central nervous system(CNS) tumors that have been followed up in our center