7 research outputs found
Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam
The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. Quantitation of the studied drugs and their binary mixtures was performed by integrating the peak areas of the characteristic well-resolved bands: υ (C=O) band at 1773 cm−1 for cefepime and ring torsion band at 826 cm−1 for metronidazole and υ (C=O) band at 1715 cm−1 for cefoperazone and ring torsion band at 1124 cm−1 for sulbactam. The results of this work were compared with the relevant spectrophotometric reported methods. This study provides data that can be used for the preparative process monitoring of the studied drugs in various dosage forms
Spectrodensitometric simultaneous determination of esomeprazole and domperidone in human plasma
A simple, rapid, cost-effective, and sensitive TLC-spectrodensitometric method for simultaneous determination of esomeprazole and domperidone was developed and tested in human plasma. Ethyl acetate: methanol: benzene: acetonitrile (5: 4: 8: 3, v/v/v/v) mobile phase was used for separation on TLC plates detected at 286 nm. The linearity ranges were 5-1200 and 2-600 ng/ spot for esomeprazole and domperidone, and limits of detection were 1.73 and 0.59 ng/spot. The effects of four variables affecting Rf were evaluated by fractional factorial design. The benzene volume and saturation time had significant effects
Effects of Polymer and Surfactant on the Dissolution and Transformation Profiles of Cocrystals in Aqueous Media
Capturing
solubility advantages of cocrystals is of great interest,
and thus to understand the mechanism by which different excipients
could maintain the supersaturation generated by cocrystals at the
course of absorption in aqueous media is essential. To achieve this
aim, the impact of different excipients on dissolution behavior of
indomethacin–saccharin (IND–SAC) were monitored by measuring
the concentrations of cocrystal components in the absence and presence
of various concentration of excipients by HPLC, and solid phases were
analyzed by differential scanning calorimetry after each experiment
and the potential of Raman spectroscopy for monitoring phase transformations
in situ was tested. No dissolution advantage was offered by cocrystals
in the absence of any solution additive. The polymer and surfactant
used in the study increased the solubility of IND but not SAC. This
differential solubilization effect is believed to have stabilized
the cocrystals for a relevant period for the absorption to take place.
This could be attributed to either decreased gap between supersaturation
and saturation of the drug or drug interaction with the additives.
Understanding the effects of excipients type and concentration on
the transformation profile is vital for designing enabling formulations
for cocrystals. The eutectic constant may be useful in selecting excipients
for stabilizing cocrystals