1,817 research outputs found
Extraction of higher-order nonlinear electronic response to strong field excitation in solids using high harmonic generation
State-of-the-art experiments employ strong ultrafast optical fields to study
the nonlinear response of electrons in solids on an attosecond time-scale.
Notably, a recent experiment retrieved a 3rd order nonlinear susceptibility by
comparing the nonlinear response induced by a strong laser field to a linear
response induced by the otherwise identical weak field. In parallel,
experiments have demonstrated high harmonic generation (HHG) in solids, a
highly nonlinear process that until recently had only been observed in gases.
The highly nonlinear nature of HHG has the potential to extract even higher
order nonlinear susceptibility terms, and thereby characterize the entire
response of the electronic system to strong field excitation. However, up till
now, such characterization has been elusive due to a lack of direct
correspondence between high harmonics and nonlinear susceptibilities. Here, we
demonstrate a regime where such correspondence can be clearly made, extracting
nonlinear susceptibilities (7th, 9th, and 11th) from sapphire of the same order
as the measured high harmonics. The extracted high order susceptibilities show
angular-resolved periodicities arising from variation in the band structure
with crystal orientation. Nonlinear susceptibilities are key to ultrafast
lightwave driven optoelectronics, allowing petahertz scaling manipulation of
the signal. Our results open a door to multi-channel signal processing,
controlled by laser polarization
Noncommutative Geometry Inspired Rotating Black Hole in Three Dimensions
We find a new rotating black hole in three-dimensional anti-de Sitter space
using an anisotropic perfect fluid inspired by the noncommutative black hole.
We deduce the thermodynamical quantities of this black hole and compare them
with those of a rotating BTZ solution.Comment: 7 page
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Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.
IntroductionPopulation-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD.Methods and analysisThe Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD. SPIROMICS AIR builds on a multicentre study of smokers with COPD, supplementing it with state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, ozone, sulfur dioxide and black carbon. In the parent study, approximately 3000 smokers with and without airflow obstruction are being followed for up to 3 years for the identification of intermediate biomarkers which predict disease progression. Subcohorts undergo daily symptom monitoring using comprehensive daily diaries. The air monitoring and modelling methods employed in SPIROMICS AIR will provide estimates of individual exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand the health effects of short-term and long-term exposures to air pollution on COPD morbidity, including exacerbation risk, patient-reported outcomes and disease progression.Ethics and disseminationThe institutional review boards of all the participating institutions approved the study protocols. The results of the trial will be presented at national and international meetings and published in peer-reviewed journals
Lepton Flavor Violation in the Two Higgs Doublet Model type III
We consider the Two Higgs Doublet Model (2HDM) of type III which leads to
Flavour Changing Neutral Currents (FCNC) at tree level in the leptonic sector.
In the framework of this model we can have, in principle, two situations: the
case (a) when both doublets acquire a vacuum expectation value different from
zero and the case (b) when only one of them is not zero. In addition, we show
that we can make two types of rotations for the flavor mixing matrices which
generates four types of lagrangians, with the rotation of type I we recover the
case (b) from the case (a) in the limit , and with the
rotation of type II we obtain the case (b) from (a) in the limit Moreover, two of the four possible lagrangians correspond to the models
of types I and II plus Flavor Changing (FC) interactions. The analitical
expressions of the partial lepton number violating widths and are derived for the cases (a) and (b) and both
types of rotations.In all cases these widths go asymptotically to zero in
the decoupling limit for all Higgses. We present from our analysis upper bounds
for the flavour changing transition and we show that such bounds
are sensitive to the VEV structure and the type of rotation utilized.Comment: 7 pages RevTeX4, 4 figures postscript, new section added and some new
reference
Bounds for Lepton Flavor Violation and the Pseudoscalar Higgs in the General Two Higgs Doublet Model using muon factor
Current experimental data from the muon factor, seems to show the
necessity of physics beyond the Standard Model (SM), since the difference
between SM and experimental predictions is 2.6. In the framework of
the General Two Higgs Doublet Model (2HDM), we calculate the muon anomalous
magnetic moment to get lower and upper bounds for the Flavour Changing (FC)
Yukawa couplings in the leptonic sector. We also obtain lower bounds for the
mass of the pseudoscalar Higgs () as a function of the parameters of
the model.Comment: 12 pages, RevTex4, 5 figures. Improved presentation, updated
experimental data, amplified analysis, new figures added. Subbmited to Phys.
Rev.
Web-based monitoring tools for Resistive Plate Chambers in the CMS experiment at CERN
The Resistive Plate Chambers (RPC) are used in the CMS experiment at the trigger level and also in the standard offline muon reconstruction. In order to guarantee the quality of the data collected and to monitor online the detector performance, a set of tools has been developed in CMS which is heavily used in the RPC system. The Web-based monitoring (WBM) is a set of java servlets that allows users to check the performance of the hardware during data taking, providing distributions and history plots of all the parameters. The functionalities of the RPC WBM monitoring tools are presented along with studies of the detector performance as a function of growing luminosity and environmental conditions that are tracked over time
Radiation background with the CMS RPCs at the LHC
The Resistive Plate Chambers (RPCs) are employed in the CMS Experiment at the LHC as dedicated trigger system both in the barrel and in the endcap. This article presents results of the radiation background measurements performed with the 2011 and 2012 proton-proton collision data collected by CMS. Emphasis is given to the measurements of the background distribution inside the RPCs. The expected background rates during the future running of the LHC are estimated both from extrapolated measurements and from simulation
Development and Optimization of an ELISA to Quantitate C3(H2O) as a Marker of Human Disease
Discovery of a C3(H2O) uptake pathway has led to renewed interest in this alternative pathway triggering form of C3 in human biospecimens. Previously, a quantifiable method to measure C3(H2O), not confounded by other complement activation products, was unavailable. Herein, we describe a sensitive and specific ELISA for C3(H2O). We initially utilized this assay to determine baseline C3(H2O) levels in healthy human fluids and to define optimal sample storage and handling conditions. We detected ~500 ng/ml of C3(H2O) in fresh serum and plasma, a value substantially lower than what was predicted based on previous studies with purified C3 preparations. After a single freeze-thaw cycle, the C3(H2O) concentration increased 3- to 4-fold (~2,000 ng/ml). Subsequent freeze-thaw cycles had a lesser impact on C3(H2O) generation. Further, we found that storage of human sera or plasma samples at 4°C for up to 22 h did not generate additional C3(H2O). To determine the potential use of C3(H2O) as a biomarker, we evaluated specimens from patients with inflammatory-driven diseases. C3(H2O) concentrations were moderately increased (1.5- to 2-fold) at baseline in sera from active systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients compared to healthy controls. In addition, upon challenge with multiple freeze-thaw cycles or incubation at 22 or 37°C, C3(H2O) generation was significantly enhanced in SLE and RA patients' sera. In bronchoalveolar lavage fluid from lung-transplant recipients, we noted a substantial increase in C3(H2O) within 3 months of acute antibody-mediated rejection. In conclusion, we have established an ELISA for assessing C3(H2O) as a diagnostic and prognostic biomarker in human diseases
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