The development of refugee law clinics in Germany in view of the refugee crisis in Europe

Coming to an unknown country, seeking for refuge, having nobody anymore, because of the family murdered by a criminal regime, not being able to speak the language of the country, having no idea of the legal system – this scenario can put refugees in very difficult circumstances, especially if the refugees need legal advice concerning their situation. There is not only the pressure of getting along with the horrific experiences the refugee went through but sometimes even legal problems that have to be solved, sometimes problems that may decide whether a person can stay in the country or has to leave it.And most of the time small issues, like how to deal with certain formalities or what steps to undertake next, are in question. This is where law clinics, especially the specialized refugee law clinics, might help

Analyse und Auswertung von Besonderheiten und Problemen bei der Konstruktion einer Serienvorrichtung im Rahmen einer praxisnahen Aufgabenstellung für die Lehre

Der Kontakt und die Zusammenarbeit mit Klein- und Mittelständischen Unternehmen in der Umgebung der Technischen Fachhochschule Wildau ist eine wichtige Wissensquelle zur Bereicherung von Lehre und Forschung. Dabei werden praxisnahe Problemstellungen im Hauptstudium in den belegbegleitenden Fächern der Spezialisierungsrichtung Maschinenbau von Studenten zunehmend angestrebt

Introduction of intensified processes into the clinical supply center

The requirements for the production of monoclonal antibodies have changed significantly over the past few years. High titer processes and flexible utilization of single use and stainless steel equipment are currently state of the art in bioprocessing. The new goals is to manufacture the same or even more product within a shorter production time while maintaining the same level of product quality. New, intensified and connected processes in the upstream and downstream departments introduced with new technologies are making these visions come true. Implementing new technologies especially under GMP conditions poses a lot of challenges. Suitability of established analytical methods needs to be demonstrated (e.g. cell count). Work flows and new standard operating procedures need to be in place for the high volume media and buffer preparations required for intensified processes. Finally, new and existing equipment needs to be integrated into the GMP production area with a special focus on safety, i.e. ensuring that the building remains structurally sound, e.g. floor load capacity. The first intensified drug substance batches comprising new technologies were successfully produced in a 1000 L - 2000 L scale in the clinical supply center at Roche in Penzberg. This presentation aims to illustrate opportunities and challenges of process intensification and connected processing in a clinical supply setting, and how to deal with it in a GMP environment. The start of the new intensified processes in a commercial facility is only a heartbeat away

Prevalence of KIG-grades 3–5 in an orthodontic practice in North Rhine Westphalia compared with results of the DMS•6 and with KZBV data

Background and aim The prevalence of tooth and jaw malocclusions in 8- to 9-year-olds was surveyed in a nationwide setting as part of the orthodontic module of the Sixth German Study on Oral Health (DMS•6), using the orthodontic indication groups (KIG) as index. Aim of this study was the detection of the prevalence of malocclusions requiring treatment according to the KIG index in statutorily insured patients of an orthodontic practice in North Rhine Westphalia, Germany, and to compare results with corresponding DMS•6 and KZBV data. Patients and methods Between 2017–2021, n=953 statutorily insured patients called for an initial consultation and subsequent determination of the KIG-classifcation and -grades. The malocclusions were classifed and graded in the highest possible KIG-grade according to valid SHI guidelines. Multiple classifcations were not recorded. KIG-grade>3 according to the valid guidelines was detected in n=815 patients. Since the DMS•6 does not contain information on KIG classifcations "U" and "S", their inclusion was waived despite evaluation, leaving data from n=683 patients for analysis and comparison. Results During the study period, n=235 patients (34.4%) had KIG-classifcation "D". More than 10% were classifed as "K" (120 patients, 17.6%), "P" (98 patients, 14.2%), "M" (89 patients, 13.0%), and "E" (81 patients, 11.9%). Of 16 possible classifcations with KIG-grade>3, "D4" was the most common with 26.6% (182 patients). The results confrm the fndings from the multicentric DMS•6 from2021 and corresponding KZBV data from 2020. Conclusions Sagittal deviations described by classifcations "D" and "M" represent with 47.4% almost half of the malocclusions with treatment need. KIG-grade D4 is the most frequent classifcation. There were no regional deviations of the prevalence of KIG-grades 3–5 in the district of Viersen / North Rhine compared with the national average, not even when scrutinizing a fve-year-period

Effizienz der skelettierten Pendulum-K-Apparatur bei der kooperationsunabhängigen Distalisation von Oberkiefermolaren : Eine klinische Pilotstudie

Purpose Conventional anchorage with exclusively intraorally anchored appliances for non-compliance molar distalization combines a palatal acrylic button with periodontal anchorage. This type of anchorage is critically discussed because of the temporary hygienic impairment of the palate and the uncertain anchoring quality of the button. A purely dentally/periodontally anchored Pendulum K appliance was developed, which is exclusively anchored via four occlusal rests. The aims of this pilot study were to examine the suitability of the skeletonized Pendulum K for distalization of maxillary molars, and to investigate the quality of this alternative anchoring modality. Patients and methods In all, 10 patients received skeletonized Pendulum K appliances attached to all maxillary premolars for bilateral molar distalization. Supporting anchorage through an acrylic button adjacent to the anterior palate was not used. The pendulum springs were initially activated on both sides with a distalization force of 220 cN each and provided with uprighting and toe-in bends. The specific force/moment system was regularly reactivated intraorally by adjustment of the distal screw. Results The study demonstrates the suitability of the skeletonized Pendulum K appliance for the distalization of maxillary molars (3.28 ± 0.73 mm). Side effects on the molars were slight distal tipping (3.50 ± 2.51°/PP, 3.00 ± 1.41°/SN) and mesial inward rotation (average 2.75 ± 7.50° and 4.50 ± 12.77°). Significant anchorage loss occurred in the form of mesialization of the incisors by 1.40 ± 0.82 mm and of the first premolars by 2.28 ± 0.85 mm. Conclusion The skeletonized Pendulum K appliance allows compliance-free upper molar distalization. Exclusively dental/periodontal anchorage resulted in a lower percentage of molar distalization compared to a conventional anchoring preparation of the Pendulum K with a palatal acrylic button. Anchorage loss had a comparatively stronger effect on the anchoring premolars but less on the incisors. Typical side effects on the molars such as distal tipping and mesial inward rotation were remarkably low

DECENTRALIZED AUTONOMOUS ORGANIZATIONS

This paper explores the potential of DAOs (Decentralized Autonomous Organizations) built on blockchain technology, which are expected to revolutionize our computing and transaction infrastructures. By combining Blockchain technology or DAGs (directed acyclic graphs)with Artificial Intelligence (AI), self-operating electronic systems could be created, making them the elementary foundations for processing, coordinating, incentivizing, and financing IoT applications and the basis of the next generation of robotics. This paper will focus on the legal classification of DAOs, with an emphasis on the mechanisms of raising capital through ICOs and NFTs as alternative financing options for easier access to capital. The potential of linking DAOs and AI is also briefly addressed. Corporate law must keep pace with this rapid change, and the question arises whether it is "sufficiently flexible to make room for the new technical possibilities" and to cover completely "new forms of organization" based on software code that may be inadequately reflected in existing regulations. Overall, this paper highlights the potential of DAOs and their impact on the future of business models, organizational structures, and financing options

Barriers to the Development of Data-Driven Services: An ISM Approach for SMEs

Data is nowadays considered as a key resource and represents the most valuable asset of our technology-driven world. However, the ability to use this resource in a value-adding way requires a holistic perspective. Small- and medium-sized enterprises in particular face major challenges in the innovation and development process. Despite preliminary research in the area of data-driven services (DDS), there is a lack of methodological analysis of the key barriers for SMEs in the context of DDS development. To address this shortcoming, we have developed an interpretive structural model based on a two-stage mixed-method approach by combining a structured literature review with practice-oriented focus group interviews to identify key barriers and their interdependencies and interactions. Our paper strengthens the knowledge of DDS development through a methodological barrier analysis and provides a guide for practitioners to eliminate the most relevant barriers to DSS development

Perception of wellbeing programs held at the industrial enterprise by employees: preparatory stage of research

Актуальность данной темы исследования определяется потребностью промышленных предприятий в улучшениях своей деятельности за счет повышения благополучия сотрудников. Цель работы: выявить, какие программы предоставляет предприятие своим сотрудникам для повышения их благополучия, и проанализировать, какие программы востребованы на предприятии. Методы исследования: анализ, синтез, прогнозирование и моделирование. Результаты: проведенное исследование поможет выявить направления, в которых следует работать предприятию для повышения благополучия сотрудников. В работе будет рассмотрена деятельность АО "Сибирская Аграрная Группа".The relevance of the subject of the research is determined by requirement of industrial enterprises for improvements of the activities due to increase in wellbeing of employees. The main aim of the study is to identify the programs provided by the company to its employees to enhance their wellbeing, and to analyze which programs are in demand at the enterprise. Methods: analysis, synthesis, modeling and forecasting. Results. The study will help identify the directions for the company to follow for increasing wellbeing of the employees