12 research outputs found
ΠΠΏΠ»ΠΈΠ² ΠΏΡΠΈΡΠΎΠ΄ΠΈ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΈ Π½Π° Π±ΡΠ΄ΠΎΠ²Ρ Ρ ΡΠ΅Π°ΠΊΡΡΠΉΠ½Ρ Π·Π΄Π°ΡΠ½ΡΡΡΡ N-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½ Ρ N-Ρ Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½
Π N-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½Π°Ρ
ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Ρ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΎΠ±ΡΡΡ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ, ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΏΠΈΡΠ°ΠΌΠΈΠ΄Π°Π»ΡΠ½ΠΎΡΡΠΈ Π°ΡΠΎΠΌΠ° Π°Π·ΠΎΡΠ° ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π°ΡΠΈΠ»ΠΎΠΊΡΠΈΠ³ΡΡΠΏΡ Π½Π° Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΡ Π² ΡΠ»ΡΡΠ°Π΅ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·ΠΌΠ°. Π ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·Π° ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌΠΈ ΡΠΏΠΈΡΡΠ°ΠΌΠΈ, Ρ
ΠΎΠ΄ ΠΈΠ·ΠΎΠΏΡΠΎΠΏΠ°Π½ΠΎΠ»ΠΈΠ·Π° N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π°ΡΠ΅ΡΠ°ΡΠ° Π½Π°ΡΡΠΈΡ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΡΠ£ N-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½Π°Ρ
Β Π±ΡΠ΄ΠΎΠ²Π° N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ·Π°ΠΌΡΡΠ½ΠΈΠΊΠ°Β Π²ΠΏΠ»ΠΈΠ²Π°ΡΒ Π½Π°Β Π·Π°Π³Π°Π»ΡΠ½Ρ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΡΡΒ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ,Β ΡΡΡΠΏΡΠ½ΡΒ ΠΏΡΡΠ°ΠΌΡΠ΄Π°Π»ΡΠ½ΠΎΡΡΡΒ Π°ΡΠΎΠΌΠ°Β Π½ΡΡΡΠΎΠ³Π΅Π½ΡΒ ΡΠ°Β ΠΌΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ Π½ΡΠΊΠ»Π΅ΠΎΡΡΠ»ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΠΌΡΡΠ΅Π½Π½Ρ Π°ΡΠΈΠ»ΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΈ Π½Π° Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΡ Ρ Π²ΠΈΠΏΠ°Π΄ΠΊΡ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ·Ρ.Β ΠΠ° Π²ΡΠ΄ΠΌΡΠ½Ρ Π²ΡΠ΄ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Ρ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ·Ρ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΈΠΌΠΈ ΡΠΏΠΈΡΡΠ°ΠΌΠΈ, ΠΏΠ΅ΡΠ΅Π±ΡΠ³ ΡΠ·ΠΎΠΏΡΠΎΠΏΠ°Π½ΠΎΠ»ΡΠ·Ρ N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½ Ρ ΠΏΡΠΈΡΡΡΠ½ΠΎΡΡΡ Π°ΡΠ΅ΡΠ°ΡΡ Π½Π°ΡΡΡΡ Π·Π°Π»Π΅ΠΆΠΈΡΡ Π²ΡΠ΄ ΠΏΡΠΈΡΠΎΠ΄ΠΈ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏ
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠΈΡΠΎΠ΄Ρ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΡ Π½Π° ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ N-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½ ΠΈ N-Ρ Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½
Π N-Π°ΡΠΈΠ»ΠΎΠΊΡΠΈ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½Π°Ρ
ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Ρ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΎΠ±ΡΡΡ ΠΊΠΎΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ, ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΏΠΈΡΠ°ΠΌΠΈΠ΄Π°Π»ΡΠ½ΠΎΡΡΠΈ Π°ΡΠΎΠΌΠ° Π°Π·ΠΎΡΠ° ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π°ΡΠΈΠ»ΠΎΠΊΡΠΈΠ³ΡΡΠΏΡ Π½Π° Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏΡ Π² ΡΠ»ΡΡΠ°Π΅ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·ΠΌΠ°. Π ΠΎΡΠ»ΠΈΡΠΈΠ΅ ΠΎΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΠΈΠ·Π° ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌΠΈ ΡΠΏΠΈΡΡΠ°ΠΌΠΈ, Ρ
ΠΎΠ΄ ΠΈΠ·ΠΎΠΏΡΠΎΠΏΠ°Π½ΠΎΠ»ΠΈΠ·Π° N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΌΠΎΡΠ΅Π²ΠΈΠ½ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π°ΡΠ΅ΡΠ°ΡΠ° Π½Π°ΡΡΠΈΡ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΏΡΠΈΡΠΎΠ΄Ρ N-Π°Π»ΠΊΠΎΠΊΡΠΈΠ³ΡΡΠΏΠΏ
ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ N-Ρ Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΠΎΠ² Ρ ΡΡΠΈΡΡΠΎΡΠ°ΡΠ΅ΡΠ°ΡΠΎΠΌ ΡΠ΅ΡΠ΅Π±ΡΠ°
Π ΡΠ»ΡΡΠ°Π΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠΈΠ»-N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΠΎΠ² Ρ ΡΡΠΈΡΡΠΎΡΠ°ΡΠ΅ΡΠ°ΡΠΎΠΌ ΡΠ΅ΡΠ΅Π±ΡΠ° ΠΎΠ±ΡΠ°Π·ΡΡΡΡΡ N,N-Π±ΠΈΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»)-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΈΠΌΠΈΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠΎΠ΅Π½ΠΈΡ N,N-Π±ΠΈΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»)-N-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΈΠΌΠΈΠ΄Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π Π‘Π ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ Π°Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° nO(Me)βΟ*NX Π² NXN-ΠΌΠ΅ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½Π°Ρ
(X = OAc, Cl, OMe, N+C5H5).</p
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds
The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrumβs acid has selectively led to the corresponding KnoevenagelβMichael adducts containing a free amino group in the imidazole fragment. The adducts derived from Meldrumβs acid have been smoothly converted into 1,7-diaryl-3-amino-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-ones and 3-(2-amino-4-aryl-1H-imidazol-5-yl)-3-arylpropanoic acids. The interaction of 2-amino-4-arylimidazoles with aromatic aldehydes or isatins and acyclic methylene active compounds has led to the formation of pyrrolo[1,2-c]imidazole-6-carbonitriles, pyrrolo[1,2-Ρ]imidazole-6-carboxylates and spiro[indoline-3,7'-pyrrolo[1,2-c]imidazoles], which can be considered as the analogues of both 3,3β-spirooxindole and 2-aminoimidazole marine sponge alkaloids
ΠΠ·Π°ΡΠΌΠΎΠ΄ΡΡ N-Ρ Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΡΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΡΠ² Π· ΡΡΠΈΡΡΠΎΡΠ°ΡΠ΅ΡΠ°ΡΠΎΠΌ ΡΡΡΠ±Π»Π°
Π ΡΠ»ΡΡΠ°Π΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΠΈΠ»-N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΠΎΠ² Ρ ΡΡΠΈΡΡΠΎΡΠ°ΡΠ΅ΡΠ°ΡΠΎΠΌ ΡΠ΅ΡΠ΅Π±ΡΠ° ΠΎΠ±ΡΠ°Π·ΡΡΡΡΡ N,N-Π±ΠΈΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»)-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΈΠΌΠΈΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠΎΠ΅Π½ΠΈΡ N,N-Π±ΠΈΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΈΠ»)-N-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΈΠΌΠΈΠ΄Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π Π‘Π ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠΊΠ°Π·Π°ΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ Π°Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° nO(Me)βΟ*NX Π² NXN-ΠΌΠ΅ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½Π°Ρ
(X = OAc, Cl, OMe, N+C5H5).Π£ ΡΠ°Π·Ρ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ ΠΌΠ΅ΡΠΈΠ»-N-Ρ
Π»ΠΎΡ-N-Π°Π»ΠΊΠΎΠΊΡΠΈΠΊΠ°ΡΠ±Π°ΠΌΠ°ΡΡΠ² Π· ΡΡΠΈΡΡΠΎΡΠ°ΡΠ΅ΡΠ°ΡΠΎΠΌ ΡΡΡΠ±Π»Π° ΡΡΠ²ΠΎΡΡΡΡΡΡΡ N,N-Π±ΡΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΡΠ»)-N-Π°Π»ΠΊΠΎΠΊΡΠΈΡΠΌΡΠ΄ΠΈ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π±ΡΠ΄ΠΎΠ²ΠΈ N,N-Π±ΡΡ(ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΡΠ»)-N-ΠΌΠ΅ΡΠΎΠΊΡΠΈΡΠΌΡΠ΄Ρ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ Π Π‘Π Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡ Π΄ΠΎΠ²Π΅ΡΡΠΈ Π½Π°ΡΠ²Π½ΡΡΡΡ Π°Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΅ΡΠ΅ΠΊΡΡΒ nO(Me)βΟ*N-XΒ Ρ N-X-N-ΠΌΠ΅ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΎΠ²ΠΈΠ½Π°Ρ
(X = OAc, Cl, OMe, N+C5H5)
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds
The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrum's acid has selectively led to the corresponding Knoevenagel-Michael adducts containing a free amino group in the imidazole fragment. The adducts derived from Meldrum's acid have been smoothly converted into 1,7-diaryl-3-amino-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-ones and 3-(2-amino-4-aryl-1H-imidazol-5-yl)-3-arylpropanoic acids. The interaction of 2-amino-4-arylimidazoles with aromatic aldehydes or isatins and acyclic methylene active compounds has led to the formation of pyrrolo[1,2-c]imidazole-6-carbonitriles, pyrrolo[1,2-Ρ]imidazole-6-carboxylates and spiro[indoline-3,7'-pyrrolo[1,2-c]imidazoles], which can be considered as the analogues of both 3,3'-spirooxindole and 2-aminoimidazole marine sponge alkaloids.status: publishe
Reassessing the evidence for tree-growth and inferred temperature change during the Common Era in Yamalia, northwest Siberia
The development of research into the history of tree growth and inferred summer temperature changes in Yamalia spanning the last 2000 years is reviewed. One focus is the evolving production of tree-ring width (TRW) and tree-ring maximum-latewood density (MXD) larch (Larix sibirica) chronologies, incorporating different applications of Regional Curve Standardisation (RCS). Another focus is the comparison of independent data representing past tree growth in adjacent Yamalia areas: Yamal and Polar Urals, and the examination of the evidence for common growth behaviour at different timescales. The sample data we use are far more numerous and cover a longer time-span at Yamal compared to the Polar Urals, but Yamal has only TRW, while there are both TRW and MXD for the Polar Urals. We use more data (sub-fossil and from living trees) than in previous dendroclimatic studies in this region. We develop a new TRW chronology for Yamal, more than 2000 years long and running up to 2005. For the Polar Urals we develop new TRW and MXD chronologies that show good agreement at short (<15 years) and medium (15β100 years) timescales demonstrating the validity of attempts to reconcile the evidence of longer-timescale information that they provide. We use a βconservativeβ application of the RCS approach (two-curve signal-free RCS), guarding against the possibility of βmodern sample biasβ: a possible inflation of recent chronology values arising out of inadvertent selection of mostly relatively fast-growing trees in recent centuries. We also transform tree indices to have a normal distribution to remove the positive chronology skew often apparent in RCS TRW chronologies. This also reduces the apparent magnitude of 20th century tree-growth levels