83 research outputs found

    One-electron states and interband optical absorption in single-wall carbon nanotubes

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    Explicit expressions for the wave functions and dispersion equation for the band p - electrons in single-wall carbon nanotubes are obtained within the method of zero-range potentials. They are then used to investigate the absorption spectrum of polarized light caused by direct interband transitions in isolated nanotubes. It is shown that, at least, under the above approximations, the circular dichroism is absent in chiral nanotubes for the light wave propagating along the tube axis. The results obtained are compared with those calculated in a similar way for a graphite plane.Comment: 16 pages, 8 figures, 1 tabl

    The Echo of Extra-territorial:Research on the Works of the History of Modern Chinese Literature of Hong Kong and Taiwan from 1950s to 1980s

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    作为与中国大陆母体隔绝的“孤儿”,香港和台湾在特殊的历史语境下出版的中国新文学史著作不仅拥有各自的特性和共性,而且呈现出了与同时期的大陆新文学史不同的文学史书写形态。 本文以50年代到80年代港台出版的比较有代表性的十一部中国新文学史著作为基本研究的对象,从港台新文学的概念辨析、体例结构、作家选择、创作评价及观念形态等不同的侧面深入分析港台学者的这类新文学史著述,并主要由“政治的”与“审美的”两个维度分析和反思港台中国新文学史的建构,重点选取司马长风的三卷本《中国新文学史》、曹聚仁的《文坛五十年》及李辉英的《中国现代文学史》等为个案文本来展开具体的讨论,藉以展示这类史著在审美意识、民族主义及...As the "orphans" that isolate with the mainland China, the works of the history of Modern Chinese Literature of Hong Kong and Taiwan which are published in a special historical context not only have their own characteristic and similarity, but also present different writing forms from the mainland works of Modern Chinese Literature of the same period. This paper tries to analyze and introspect...学位:文学硕士院系专业:人文学院中文系_文艺学学号:1022009115195

    Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells

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    Altres ajuts: A. acknowledges funding from Fundación Científica Asociación Española Contra el Cáncer (IDEAS SEMILLA AECC 2020/IDEAS20033PUIG) and Instituto de Salud Carlos III co-financed by the European Regional Development Fund (ERDF) . The APC was funded by Instituto de Salud Carlos III co-financed by the European Regional Development Fund (ERDF). H.G is funded by the European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE; under the projects PAC "NETDIAMOND" POCI-01-0145-FEDER-016385; HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323; POCI-01-0145-FEDER-007440, CENTRO-01-0145-FEDER-032179, CENTRO-01-0145-FEDER-032414, POCI-01-0145-FEDER-022122, FCTUID/NEU/04539/2013, UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/04539/2020.Connexin 43 (Cx43) forms gap junctions that mediate the direct intercellular diffusion of ions and small molecules between adjacent cells. Cx43 displays both pro- and anti-tumorigenic properties, but the mechanisms underlying these characteristics are not fully understood. Tunneling nanotubes (TNTs) are long and thin membrane projections that connect cells, facilitating the exchange of not only small molecules, but also larger proteins, organelles, bacteria, and viruses. Typically, TNTs exhibit increased formation under conditions of cellular stress and are more prominent in cancer cells, where they are generally thought to be pro-metastatic and to provide growth and survival advantages. Cx43 has been described in TNTs, where it is thought to regulate small molecule diffusion through gap junctions. Here, we developed a high-fidelity CRISPR/Cas9 system to knockout (KO) Cx43. We found that the loss of Cx43 expression was associated with significantly reduced TNT length and number in breast cancer cell lines. Notably, secreted factors present in conditioned medium stimulated TNTs more potently when derived from Cx43-expressing cells than from KO cells. Moreover, TNT formation was significantly induced by the inhibition of several key cancer signaling pathways that both regulate Cx43 and are regulated by Cx43, including RhoA kinase (ROCK), protein kinase A (PKA), focal adhesion kinase (FAK), and p38. Intriguingly, the drug-induced stimulation of TNTs was more potent in Cx43 KO cells than in wild-type (WT) cells. In conclusion, this work describes a novel non-canonical role for Cx43 in regulating TNTs, identifies key cancer signaling pathways that regulate TNTs in this setting, and provides mechanistic insight into a pro-tumorigenic role of Cx43 in cancer

    Measurement of proton, deuteron, triton, and α particle emission after nuclear muon capture on Al, Si, and Ti with the AlCap experiment

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    Heavy charged particles after nuclear muon capture are an important nuclear physics background to the muon-to-electron conversion experiments Mu2e and COMET, which will search for charged lepton flavor violation at an unprecedented level of sensitivity. The AlCap experiment measured the yield and energy spectra of protons, deuterons, tritons, and alpha particles emitted after the nuclear capture of muons stopped in Al, Si, and Ti in the low energy range relevant for the muon-to-electron conversion experiments. Individual charged particle types were identified in layered silicon detector packages and their initial energy distributions were unfolded from the observed energy spectra. Detailed information on yields and energy spectra for all observed nuclei are presented in the paper.Comment: 24 pages, 19 figure

    Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop

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    Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc+ myeloid cells lie in close anatomical proximity to MB-HSCs and produce histamine, which activates the H2 receptor on MB-HSCs to promote their quiescence and self-renewal. Depleting histamine-producing cells enforces cell cycle entry, induces loss of serial transplant capacity, and sensitizes animals to chemotherapeutic injury. Increasing demand for myeloid cells via lipopolysaccharide (LPS) treatment specifically recruits MB-HSCs and progenitors into the cell cycle; cycling MB-HSCs fail to revert into quiescence in the absence of histamine feedback, leading to their depletion, while an H2 agonist protects MB-HSCs from depletion after sepsis. Thus, histamine couples lineage-specific physiological demands to intrinsically primed MB-HSCs to enforce homeostasis. Chen et al. show that histidine decarboxylase (Hdc) marks quiescent myeloid-biased HSCs (MB-HSCs). Daughter myeloid cells form a spatial cluster with Hdc+ MB-HSCs and secrete histamine to enforce their quiescence and protect them from depletion, following activation by a variety of physiologic insults

    Microwave radiometry in monitoring and emergency mapping of water seepage and dangerously high groundwaters, Journal of Telecommunications and Information Technology, 2007, nr 1

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    Detailed and geo-referenced maps identifying the locations of saturated and dry levees can be produced using microwave radiometric measurements from a light aircraft or helicopter, and integrated with GPS for positioning and orientation. The development of synergetic remote sensing technology for raised groundwater and seepage detection by the joint use of microwave and optical data along with GIS databases is an effective and most contemporary way of supporting risk assessment and facilitating disaster prevention and management. In this paper we present a remote sensing microwave technology for monitoring and detection of areas of water seepage through irrigation constructions, levees and dykes as well as for revealing areas with dangerously high groundwater level. The possibility for emergency response mapping, integrated with GPS and GIS data, facilitates the risk assessment and management services. The passive microwave radiometry (PMR) is based on spectral measurements in the millimetre to decimetre range of wavelengths. Compared to other remote sensing techniques, such as colour and infrared photography, thermal images and lidar, PMR is the only technology taking measurements under the earth’s surface and therefore is very well suited for water seepage and underground water monitoring in a fast and reliable way

    Measurement of proton, deuteron, triton, and alpha particle emission after nuclear muon capture on Al, Si, and Ti with the AlCap experiment

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    Background: Heavy charged particles after nuclear muon capture are an important nuclear physics background to the muon-to-electron conversion experiments Mu2e and COMET, which will search for charged lepton flavor violation at an unprecedented level of sensitivity. Purpose: The AlCap experiment aimed to measure the yield and energy spectra of protons, deuterons, tritons, and α particles emitted after the nuclear capture of muons stopped in Al, Si, and Ti in the low-energy range relevant for the muon-to-electron conversion experiments. Methods: Individual charged particle types were identified in layered silicon detector packages and their initial energy distributions were unfolded from the observed energy spectra. Results: The proton yields per muon capture were determined as Y p ( Al ) = 26.64 ( 28 stat. ) ( 77 syst. ) × 10 − 3 and Y p ( Ti ) = 26.48 ( 35 ) ( 80 ) × 10 − 3 in the energy range 3.5–20.0 MeV, and as Y p ( Si ) = 52.5 ( 6 ) ( 18 ) × 10 − 3 in the energy range 4.0–20.0 MeV. Detailed information on yields and energy spectra for all observed nuclei are presented in the paper. Conclusions: The yields in the candidate muon stopping targets, Al and Ti, are approximately half of that in Si, which was used in the past to estimate this background. The reduced background allows for less shielding and a better energy resolution in these experiments. It is anticipated that the comprehensive information presented in this paper will stimulate modern theoretical calculations of the rare process of muon capture with charged particle emission and inform the design of future muon-to-electron conversion experiments

    Electric dipole moments and the search for new physics

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    Static electric dipole moments of nondegenerate systems probe mass scales for physics beyond the Standard Model well beyond those reached directly at high energy colliders. Discrimination between different physics models, however, requires complementary searches in atomic-molecular-and-optical, nuclear and particle physics. In this report, we discuss the current status and prospects in the near future for a compelling suite of such experiments, along with developments needed in the encompassing theoretical framework.Comment: Contribution to Snowmass 2021; updated with community edits and endorsement

    Mu2e Technical Design Report

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    The Mu2e experiment at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the preliminary design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-2 approval.Comment: compressed file, 888 pages, 621 figures, 126 tables; full resolution available at http://mu2e.fnal.gov; corrected typo in background summary, Table 3.
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