40 research outputs found
Correction: Carbon dioxide uptake from natural gas by binary ionic liquidâwater mixtures
Correction for âCarbon dioxide uptake from natural gas by binary ionic liquidâwater mixturesâ by Kris Anderson et al., Green Chem., 2015, DOI: 10.1039/c5gc00720h
Carbon dioxide uptake from natural gas by binary ionic liquid water mixtures
[EN] Carbon dioxide solubility in a set of carboxylate ionic liquids formulated with stoicheiometric amounts of water is found to be significantly higher than for other ionic liquids previously reported. This is due to synergistic chemical and physical absorption. The formulated ionic liquid/water mixtures show greatly enhanced carbon dioxide solubility relative to both anhydrous ionic liquids and aqueous ionic liquid solutions, and are competitive with commercial chemical absorbers, such as activated N-methyldiethanolamine or monoethanolamine.The authors would like to acknowledge PETRONAS for financial support of this research, and Cytec (especially Dr Al Robertson) for supplying some of the phosphonium ionic liquids used.Anderson, K.; Atkins, MP.; Estager, J.; Kuah, Y.; Ng, S.; Oliferenko, AA.; Plechkova, NV.... (2015). Carbon dioxide uptake from natural gas by binary ionic liquid water mixtures. Green Chemistry. 17(8):4340-4354. https://doi.org/10.1039/c5gc00720hS43404354178Cenovus, http://www.cenovus.com/operations/technology/co2-enhanced-oil-recovery.htmlV. Alvarado and E.Manrique, Enhanced Oil Recovery: Field Planning and Development Strategies, Gulf Professional Publishing, Amsterdam, 2010British Petroleum , In Salah Gas, http://www.insalahco2.com/index.php?option=com_content&view=frontpage&Itemid=1&lang=enN. Stern , The Economics of Climate Change: The Stern Review, Cambridge University Press, Cambridge, 2007Alvarado, V., & Manrique, E. (2010). Enhanced Oil Recovery: An Update Review. Energies, 3(9), 1529-1575. doi:10.3390/en3091529S. Rackley , Carbon Capture and Storage, Elsevier Science, Oxford, 2009H. Huppert , Carbon Capture and Storage in Europe EASAC Policy Report 20, German National Academy of Sciences, Leopoldina, 2013Organisation for the Prohibition of Chemical Weapons (OPCW) , The Chemical Weapons Convention, http://www.opcw.org/html/db/cwc/eng/cwc_frameset.htmlRubin, E. S., Mantripragada, H., Marks, A., Versteeg, P., & Kitchin, J. (2012). The outlook for improved carbon capture technology. Progress in Energy and Combustion Science, 38(5), 630-671. doi:10.1016/j.pecs.2012.03.003G. H. Koch , M. P. H.Brongers, N. G.Thompson, Y. P.Virmani and J. H.Payer, Corrosion Costs and Preventive Strategies in the United States FHWA-RD-01-156, CC Technologies Laboratories, Inc, NACE International, 2001Law Offices of Casper Meadows Schwartz & Cook, â$80 Million Recovery in Toxic Exposure Suitâ, http://www.cmslaw.com/Verdicts-Settlements/80-Million-Recovery-in-Toxic-Exposure-Suit.shtmlL. Grunwald , U.S. EPA Cites UNOCAL for Spill Violations, Press Release, United States Environmental Protection Agency, 1995Lee, K. B., Beaver, M. G., Caram, H. S., & Sircar, S. (2008). Reversible Chemisorbents for Carbon Dioxide and Their Potential Applications. Industrial & Engineering Chemistry Research, 47(21), 8048-8062. doi:10.1021/ie800795yDu, N., Park, H. B., Dal-Cin, M. M., & Guiver, M. D. (2012). Advances in high permeability polymeric membrane materials for CO2separations. Energy Environ. Sci., 5(6), 7306-7322. doi:10.1039/c1ee02668bM. Freemantle , An Introduction to Ionic Liquids, RSC Publications, Cambridge, UK, 2010Earle, M. J., Esperança, J. M. S. S., Gilea, M. A., Canongia Lopes, J. N., Rebelo, L. P. N., Magee, J. W., ⌠Widegren, J. A. (2006). The distillation and volatility of ionic liquids. Nature, 439(7078), 831-834. doi:10.1038/nature04451Forsyth, M., Howlett, P. C., Tan, S. K., MacFarlane, D. R., & Birbilis, N. (2006). An Ionic Liquid Surface Treatment for Corrosion Protection of Magnesium Alloy AZ31. Electrochemical and Solid-State Letters, 9(11), B52. doi:10.1149/1.2344826Fraser, K. J., & MacFarlane, D. R. (2009). Phosphonium-Based Ionic Liquids: An Overview. Australian Journal of Chemistry, 62(4), 309. doi:10.1071/ch08558K. R. Seddon , Ionic liquids: Designer solvents?, in The International George Papatheodorou Symposium: Proceedings, ed. S. Boghosian, V. Dracopoulos, C. G. Kontoyannis and G. A. Voyiatzis, Institute of Chemical Engineering and High Temperature Chemical Processes, Patras, 1999, pp. 131â135M. Deetlefs , M.Fanselow and K. R.Seddon, RSC Adv.W. Freyland , Coulombic Fluids: Bulk and Interfaces, Springer, Heidelberg, 2011Electrodeposition from Ionic Liquids, ed. F. Endres, D. MacFarlane and A. Abbott, Wiley-VCH, Weinheim, 2008Electrochemical Aspects of Ionic Liquids, ed. H. Ohno, Wiley-Interscience, Hoboken, New Jersey, 2005Ionic Liquids: From Knowledge to Application, ed. N. V. Plechkova, R. D. Rogers and K. R. Seddon, American Chemical Society, Washington D.C., 2009Ionic Liquids in Synthesis, ed. P. Wasserscheid and T. Welton, Wiley-VCH, Weinheim, 2nd edn, 2008Plechkova, N. V., & Seddon, K. R. (2008). Applications of ionic liquids in the chemical industry. Chem. Soc. Rev., 37(1), 123-150. doi:10.1039/b006677jIonic Liquids UnCOILed: Critical Expert Overviews, ed. N. V. Plechkova and K. R. Seddon, Wiley, Hoboken, New Jersey, 2013Ionic Liquids Further UnCOILed: Critical Expert Overviews, ed. N. V. Plechkova and K. R. Seddon, Wiley, Hoboken, New Jersey, 2014Ionic Liquids Completely UnCOILed: Critical Expert Overviews, ed. N. V. Plechkova and K. R. Seddon, Wiley, Hoboken, New Jersey, 2015Blanchard, L. A., Hancu, D., Beckman, E. J., & Brennecke, J. F. (1999). Green processing using ionic liquids and CO2. Nature, 399(6731), 28-29. doi:10.1038/19887C. VillagrĂĄn , C. E.Banks, M.Deetlefs, G.Driver, W. R.Pitner, R. G.Compton and C.Hardacre, Chloride Determination in Ionic Liquids, in Ionic Liquids IIIB: Fundamentals, Progress, Challenges, and Opportunities - Transformations and Processes, ed. R. D. Rogers and K. R. Seddon, ACS Symp. Ser., Vol. 902, American Chemical Society, Washington D.C., 2005, vol. 902, pp. 244â258J. L. Anthony , E. J.Maginn and J. F.Brennecke, Gas Solubilities in 1-n-Butyl-3-methylimidazolium Hexafluorophosphate, in Ionic Liquids: Industrial Applications to Green Chemistry, ed. R. D. Rogers and K. R. Seddon, ACS Symp. Ser, Vol. 818, American Chemical Society, Washington D.C., 2002, vol. 818, pp. 260â269J. H. Davis Jr. , Working Salts: Syntheses and Uses of Ionic Liquids Containing Functionalized Ions, in Ionic Liquids: Industrial Applications to Green Chemistry, ed. R. D. Rogers and K. R. Seddon, ACS Symp. Ser, Vol. 818, American Chemical Society, Washington D.C., 2002, vol. 818, pp. 247â259Bates, E. D., Mayton, R. D., Ntai, I., & Davis, J. H. (2002). CO2Capture by a Task-Specific Ionic Liquid. Journal of the American Chemical Society, 124(6), 926-927. doi:10.1021/ja017593dWang, C., Luo, X., Zhu, X., Cui, G., Jiang, D., Deng, D., ⌠Dai, S. (2013). The strategies for improving carbon dioxide chemisorption by functionalized ionic liquids. RSC Advances, 3(36), 15518. doi:10.1039/c3ra42366bRamdin, M., de Loos, T. W., & Vlugt, T. J. H. (2012). State-of-the-Art of CO2Capture with Ionic Liquids. Industrial & Engineering Chemistry Research, 51(24), 8149-8177. doi:10.1021/ie3003705Zhang, X., Zhang, X., Dong, H., Zhao, Z., Zhang, S., & Huang, Y. (2012). Carbon capture with ionic liquids: overview and progress. Energy & Environmental Science, 5(5), 6668. doi:10.1039/c2ee21152aYokozeki, A., & Shiflett, M. B. (2009). Separation of Carbon Dioxide and Sulfur Dioxide Gases Using Room-Temperature Ionic Liquid [hmim][Tf2N]. Energy & Fuels, 23(9), 4701-4708. doi:10.1021/ef900649cCabaço, M. I., Besnard, M., Danten, Y., & Coutinho, J. A. P. (2012). Carbon Dioxide in 1-Butyl-3-methylimidazolium Acetate. I. Unusual Solubility Investigated by Raman Spectroscopy and DFT Calculations. The Journal of Physical Chemistry A, 116(6), 1605-1620. doi:10.1021/jp211211nCarvalho, P. J., AĚlvarez, V. H., SchroĚder, B., Gil, A. M., Marrucho, I. M., Aznar, M., ⌠Coutinho, J. A. P. (2009). Specific Solvation Interactions of CO2on Acetate and Trifluoroacetate Imidazolium Based Ionic Liquids at High Pressures. The Journal of Physical Chemistry B, 113(19), 6803-6812. doi:10.1021/jp901275bGoodrich, B. F., de la Fuente, J. C., Gurkan, B. E., Zadigian, D. J., Price, E. A., Huang, Y., & Brennecke, J. F. (2011). Experimental Measurements of Amine-Functionalized Anion-Tethered Ionic Liquids with Carbon Dioxide. Industrial & Engineering Chemistry Research, 50(1), 111-118. doi:10.1021/ie101688aGoodrich, B. F., de la Fuente, J. C., Gurkan, B. E., Lopez, Z. K., Price, E. A., Huang, Y., & Brennecke, J. F. (2011). Effect of Water and Temperature on Absorption of CO2by Amine-Functionalized Anion-Tethered Ionic Liquids. The Journal of Physical Chemistry B, 115(29), 9140-9150. doi:10.1021/jp2015534Ferguson, J. L., Holbrey, J. D., Ng, S., Plechkova, N. V., Seddon, K. R., Tomaszowska, A. A., & Wassell, D. F. (2011). A greener, halide-free approach to ionic liquid synthesis. Pure and Applied Chemistry, 84(3), 723-744. doi:10.1351/pac-con-11-07-21Shiflett, M. B., Kasprzak, D. J., Junk, C. P., & Yokozeki, A. (2008). Phase behavior of {carbon dioxide+[bmim][Ac]} mixtures. The Journal of Chemical Thermodynamics, 40(1), 25-31. doi:10.1016/j.jct.2007.06.003Shiflett, M. B., & Yokozeki, A. (2009). Phase Behavior of Carbon Dioxide in Ionic Liquids: [emim][Acetate], [emim][Trifluoroacetate], and [emim][Acetate] + [emim][Trifluoroacetate] Mixtures. Journal of Chemical & Engineering Data, 54(1), 108-114. doi:10.1021/je800701jShiflett, M. B., Drew, D. W., Cantini, R. A., & Yokozeki, A. (2010). Carbon Dioxide Capture Using Ionic Liquid 1-Butyl-3-methylimidazolium Acetate. Energy & Fuels, 24(10), 5781-5789. doi:10.1021/ef100868aCabaço, M. I., Besnard, M., Danten, Y., & Coutinho, J. A. P. (2011). Solubility of CO2in 1-Butyl-3-methyl-imidazolium-trifluoro Acetate Ionic Liquid Studied by Raman Spectroscopy and DFT Investigations. The Journal of Physical Chemistry B, 115(13), 3538-3550. doi:10.1021/jp111453aGurau, G., RodrĂguez, H., Kelley, S. P., Janiczek, P., Kalb, R. S., & Rogers, R. D. (2011). Demonstration of Chemisorption of Carbon Dioxide in 1,3-Dialkylimidazolium Acetate Ionic Liquids. Angewandte Chemie International Edition, 50(50), 12024-12026. doi:10.1002/anie.201105198Besnard, M., Cabaço, M. I., Vaca ChĂĄvez, F., Pinaud, N., SebastiĂŁo, P. J., Coutinho, J. A. P., ⌠Danten, Y. (2012). CO2 in 1-Butyl-3-methylimidazolium Acetate. 2. NMR Investigation of Chemical Reactions. The Journal of Physical Chemistry A, 116(20), 4890-4901. doi:10.1021/jp211689zJaniczek, P., Kalb, R. S., Thonhauser, G., & Gamse, T. (2012). Carbon dioxide absorption in a technical-scale-plant utilizing an imidazolium based ionic liquid. Separation and Purification Technology, 97, 20-25. doi:10.1016/j.seppur.2012.03.003Ober, C. A., & Gupta, R. B. (2012). pH Control of Ionic Liquids with Carbon Dioxide and Water: 1-Ethyl-3-methylimidazolium Acetate. Industrial & Engineering Chemistry Research, 51(6), 2524-2530. doi:10.1021/ie201529dStevanovic, S., PodgorĹĄek, A., PĂĄdua, A. A. H., & Costa Gomes, M. F. (2012). Effect of Water on the Carbon Dioxide Absorption by 1-Alkyl-3-methylimidazolium Acetate Ionic Liquids. The Journal of Physical Chemistry B, 116(49), 14416-14425. doi:10.1021/jp3100377Stevanovic, S., Podgorsek, A., Moura, L., Santini, C. C., Padua, A. A. H., & Costa Gomes, M. F. (2013). Absorption of carbon dioxide by ionic liquids with carboxylate anions. International Journal of Greenhouse Gas Control, 17, 78-88. doi:10.1016/j.ijggc.2013.04.017Wang, G., Hou, W., Xiao, F., Geng, J., Wu, Y., & Zhang, Z. (2011). Low-Viscosity Triethylbutylammonium Acetate as a Task-Specific Ionic Liquid for Reversible CO2Absorption. Journal of Chemical & Engineering Data, 56(4), 1125-1133. doi:10.1021/je101014qWilhelm, E., Battino, R., & Wilcock, R. J. (1977). Low-pressure solubility of gases in liquid water. Chemical Reviews, 77(2), 219-262. doi:10.1021/cr60306a003Miyano, Y., & Fujihara, I. (2004). Henryâs constants of carbon dioxide in methanol at 250â500 K. Fluid Phase Equilibria, 221(1-2), 57-62. doi:10.1016/j.fluid.2004.04.017Fernandez, E. S., & Goetheer, E. L. V. (2011). DECAB: Process development of a phase change absorption process. Energy Procedia, 4, 868-875. doi:10.1016/j.egypro.2011.01.131Zhang, J., Zhang, S., Dong, K., Zhang, Y., Shen, Y., & Lv, X. (2006). Supported Absorption of CO2 by Tetrabutylphosphonium Amino Acid Ionic Liquids. Chemistry - A European Journal, 12(15), 4021-4026. doi:10.1002/chem.200501015Saravanamurugan, S., Kunov-Kruse, A. J., Fehrmann, R., & Riisager, A. (2014). Amine-Functionalized Amino Acid-based Ionic Liquids as Efficient and High-Capacity Absorbents for CO2. ChemSusChem, 7(3), 897-902. doi:10.1002/cssc.201300691J. Speight , Lange's Handbook of Chemistry, McGraw-Hill, New York, 16th edn, 2005, Section 1.18, pp. 1.310â1.314Cammarata, L., Kazarian, S. G., Salter, P. A., & Welton, T. (2001). Molecular states of water in room temperature ionic liquidsElectronic Supplementary Information available. See http://www.rsc.org/suppdata/cp/b1/b106900d/. Physical Chemistry Chemical Physics, 3(23), 5192-5200. doi:10.1039/b106900dNitta, I., Tomiie, Y., & Koo, C. H. (1952). The crystal structure of potassium bicarbonate, KHCO3. Acta Crystallographica, 5(2), 292-292. doi:10.1107/s0365110x52000848Sass, R. L., & Scheuerman, R. F. (1962). The crystal structure of sodium bicarbonate. Acta Crystallographica, 15(1), 77-81. doi:10.1107/s0365110x62000158AdamovĂĄ, G., Gardas, R. L., Nieuwenhuyzen, M., Puga, A. V., Rebelo, L. P. N., Robertson, A. J., & Seddon, K. R. (2012). Alkyltributylphosphonium chloride ionic liquids: synthesis, physicochemical properties and crystal structure. Dalton Transactions, 41(27), 8316. doi:10.1039/c1dt10466gGottlieb, H. E., Kotlyar, V., & Nudelman, A. (1997). NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities. The Journal of Organic Chemistry, 62(21), 7512-7515. doi:10.1021/jo971176vSheldrick, G. M. (2007). A short history ofSHELX. Acta Crystallographica Section A Foundations of Crystallography, 64(1), 112-122. doi:10.1107/s0108767307043930Allen, F. H., & Motherwell, W. D. S. (2002). Applications of the Cambridge Structural Database in organic chemistry and crystal chemistry. Acta Crystallographica Section B Structural Science, 58(3), 407-422. doi:10.1107/s0108768102004895Ramnial, T., Taylor, S. A., Bender, M. L., Gorodetsky, B., Lee, P. T. K., Dickie, D. A., ⌠Clyburne, J. A. C. (2008). Carbon-Centered Strong Bases in Phosphonium Ionic Liquids. The Journal of Organic Chemistry, 73(3), 801-812. doi:10.1021/jo701289dDietzel, P. D. C., & Jansen, M. (2002). Tetramethylphosphonium hydrogen carbonate. Acta Crystallographica Section E Structure Reports Online, 58(9), o1003-o1004. doi:10.1107/s1600536802013168Li, H., Hou, Y., & Yang, Y. (2011). Tetraethylammonium bicarbonate trihydrate. Acta Crystallographica Section E Structure Reports Online, 67(8), o1991-o1991. doi:10.1107/s1600536811026080McMullan, R., & Jeffrey, G. A. (1959). Hydrates of the Tetranâbutyl and Tetraiâamyl Quaternary Ammonium Salts. The Journal of Chemical Physics, 31(5), 1231-1234. doi:10.1063/1.1730574Smiglak, M., Hines, C. C., & Rogers, R. D. (2010). New hydrogen carbonate precursors for efficient and byproduct-free syntheses of ionic liquids based on 1,2,3-trimethylimidazolium and N,N-dimethylpyrrolidinium cores. Green Chemistry, 12(3), 491. doi:10.1039/b920003gMaton, C., Van Hecke, K., & Stevens, C. V. (2015). Peralkylated imidazolium carbonate ionic liquids: synthesis using dimethyl carbonate, reactivity and structure. New Journal of Chemistry, 39(1), 461-468. doi:10.1039/c4nj01301hBondi, A. (1964). van der Waals Volumes and Radii. The Journal of Physical Chemistry, 68(3), 441-451. doi:10.1021/j100785a001Van den Berg, J.-A., & Seddon, K. R. (2003). Critical Evaluation of CâH¡¡¡X Hydrogen Bonding in the Crystalline State. Crystal Growth & Design, 3(5), 643-661. doi:10.1021/cg034083hAdamovĂĄ, G., Canongia Lopes, J. N., Rebelo, L. P. N., Santos, L. M. N. B., Seddon, K. R., & Shimizu, K. (2014). The alternation effect in ionic liquid homologous series. Phys. Chem. Chem. Phys., 16(9), 4033-4038. doi:10.1039/c3cp54584aAdamovĂĄ, G., Gardas, R. L., Nieuwenhuyzen, M., Puga, A. V., Rebelo, L. P. N., Robertson, A. J., & Seddon, K. R. (2012). Alkyltributylphosphonium chloride ionic liquids: synthesis, physicochemical properties and crystal structure. Dalton Transactions, 41(27), 8316. doi:10.1039/c1dt10466gM. B. Shiflett and A.Yokozeki, Phase Behaviour of Gases in Ionic Liquids, in Ionic Liquids UnCOILed: Critical Expert Overviews, ed. N. V. Plechkova and K. R. Seddon, Wiley, Hoboken, New Jersey, 2013, pp. 349â398Ibrahim, A. Y., Ashour, F. H., Ghallab, A. O., & Ali, M. (2014). Effects of piperazine on carbon dioxide removal from natural gas using aqueous methyl diethanol amine. Journal of Natural Gas Science and Engineering, 21, 894-899. doi:10.1016/j.jngse.2014.10.011Anonymous , Piperazine â Why It's Used And How It Works, The Contractor (Optimized Gas Treating, Inc.), Houston, 2008, 2 [4], http://www.ogtrt.com/files/contactors/vol_2_issue_4.pd
A General Treatment of Solubility. 2. QSPR Prediction of Free Energies of Solvation of Specified Solutes in Ranges of Solvents
The Gene Ontology knowledgebase in 2023
The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge currently derives from experiments carried out in a relatively small number of model organisms. Here, we provide an updated overview of the GO knowledgebase, as well as the efforts of the broad, international consortium of scientists that develops, maintains, and updates the GO knowledgebase. The GO knowledgebase consists of three components: (1) the GO-a computational knowledge structure describing the functional characteristics of genes; (2) GO annotations-evidence-supported statements asserting that a specific gene product has a particular functional characteristic; and (3) GO Causal Activity Models (GO-CAMs)-mechanistic models of molecular "pathways" (GO biological processes) created by linking multiple GO annotations using defined relations. Each of these components is continually expanded, revised, and updated in response to newly published discoveries and receives extensive QA checks, reviews, and user feedback. For each of these components, we provide a description of the current contents, recent developments to keep the knowledgebase up to date with new discoveries, and guidance on how users can best make use of the data that we provide. We conclude with future directions for the project
Boiling Points of Ternary Azeotropic Mixtures Modeled with the Use of the Universal Solvation Equation and Neural Networks
Azeotropic mixtures, an important class of technological
fluids, constitute a challenge to theoretical modeling of their properties.
The number of possible intermolecular interactions in multicomponent
systems grows combinatorially as the number of components increases.
Ab initio methods are barely applicable, because rather large clusters
would need to be calculated, which is prohibitively time-consuming.
The quantitative structureâproperty relationships (QSPR) method,
which is efficient and extremely fast, could be a viable alternative
approach, but the QSPR methodology requires adequate modification
to provide a consistent treatment of multicomponent mixtures. We now
report QSPR models for the prediction of normal boiling points of
ternary azeotropic mixtures based on a training set of 78 published
data points. A limited set of meticulously designed descriptors, together
comprising the Universal Solvation Equation (<i>J. Chem. Inf.
Model.</i> <b>2009</b>, <i>49</i>, 634), was
used to provide input parameters for multiple regression and neural
network models. The multiple regression model thus obtained is good
for explanatory purposes, while the neural network model provides
a better quality of fit, which is as high as 0.995 in terms of squared
correlation coefficient. This model was also properly validated and
analyzed in terms of parameter contributions and their nonlinearity
characteristics
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Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors
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