The Left-Right SU(3)(L)xSU(3)(R)xU(1)(X) Model with Light, keV and Heavy Neutrinos

We construct a full left-right model for the electroweak interactions based on the $SU(3)_{L}\otimes SU(3)_{R}\otimes U(1)_{X}$ gauge symmetry. The fermion content of the model is such that anomaly cancellation restricts the number of families to be a multiple of three. One of the most important features of the model is the joint presence of three light active neutrinos, three additional neutrinos at keV mass scale, and six heavy ones with masses around\textbf{$10^{11}$} GeV. They form a well-motivated part of the spectrum in the sense they address challenging problems related to neutrino oscillation, warm dark matter, and baryogenesis through leptogenesis.Comment: 11 pages. Small corrections and typos fixed. Accepted for publication in PR

Structure and energetics of molecular point defects in ice Ih

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORWe present a first-principles study of the molecular vacancy and three distinct molecular interstitial structures in ice Ih. The results indicate that, due to its bonding to the surrounding hydrogen-bond network, the bond-center (Bc) configuration is the favored molecular interstitial in ice Ih. A comparison between the vacancy and the Bc interstitial suggests that the former is the predominant molecular point defect for T ≤ 200K although a crossover scenario in which the latter becomes favored below the melting point is conceivable.We present a first-principles study of the molecular vacancy and three distinct molecular interstitial structures in ice Ih. The results indicate that, due to its bonding to the surrounding hydrogen-bond network, the bond-center (Bc) configuration is the favored molecular interstitial in ice Ih. A comparison between the vacancy and the Bc interstitial suggests that the former is the predominant molecular point defect for T ≤ 200K although a crossover scenario in which the latter becomes favored below the melting point is conceivable.971514FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORSem informaçãoSem informaçãoSem informaçãoThe authors gratefully acknowledge financial support from the Brazilian agencies FAPESP, CNPq, and CAPES. M. K. acknowledges R.W. Whitworth for stimulating discussions. Part of the calculations were carried out at the High-Performance Computing Facility at CCJDRIFGW-UNICAMP

Neutrino Decay and Neutrinoless Double Beta Decay in a 3-3-1 Model

In this work we show that the implementation of spontaneous breaking of the lepton number in the 3-3-1 model with right-handed neutrinos gives rise to fast neutrino decay with majoron emission and generates a bunch of new contributions to the neutrinoless double beta decay.Comment: Version accepted for publication in the Phys. Rev.

Orientational Defects in Ice Ih: An Interpretation of Electrical Conductivity Measurements

We present a first-principles study of the structure and energetics of Bjerrum defects in ice Ih and compare the results to experimental electrical conductivity data. While the DFT result for the activation energy is in good agreement with experiment, we find that its two components have quite different values. Aside from providing new insight into the fundamental parameters of the microscopic electrical theory of ice, our results suggest the activity of traps in doped ice in the temperature regime typically assumed to be controlled by the free migration of L defects.Comment: 4 pages, 4 Figures, 1 Tabl

Protein Supplementation Is Vital for Beef Cattle Fed with Tropical Pasture

The production of beef on pasture is one of the potentials of Brazilian agriculture, mainly due to the territorial extension and climatic conditions. Therefore, the production of beef on tropical pastures mainly consists of the use of tropical forages; when correctly handled, forage plants show good productivity and improvement in the nutritive value. Among main factors that affect the performance of beef cattle fed on pastures, the availability and quality of the pasture stand first. In tropical regions, during the dry period of the year, the production of forage as well as its nutritive value is diminished. Hence, it is necessary to use protein supplements as a feed strategy to promote increased intake and improved nutrient utilization efficiency by animals. In view of this, by-products of biodiesel from oilseeds, such as peanuts, cottonseed and sunflower seeds, with high nutritional values can be used as an animal feed alternative to the protein sources commonly used for the formulation of supplements. Protein supplementation contributes to an increase in live weight gain as well as improvement in ruminal microbiota activity and, consequently, potentiates nutrient utilization efficiency in beef cattle fed with tropical pasture

Aspectos da nidificação e forrageamento de Xylocopa (Neoxylocopa) grisescens Lepeletier, 1841 (Hymenoptera: Apidae: Xylocopini) nas dunas do médio São Francisco, Bahia

Xylocopa (Neoxylocopa) grisescens Lepeletier, 1841 (Hymenoptera: Apidae: Xylocopini) was the most abundant species of this genus in the study area. Nests were found in the riparian forests of the mid San Francisco River. The architecture of five X. grisescens nests built in branches of Capparis sp. (Capparaceae) are described. The length and diameter of the nesting substrates varied between 68-87cm and 17-23cm, respectively. Each nest had one rounded entrance with mean diameter of 16.0mm ± 1.08mm (n=7). Cells were barrel-shaped in linear series in the galleries, with 2.40cm ± 0.18cm in length, 2.01cm ± 0.11cm in diameter and a mean volume of 7.59cm ± 0.79cm3. Cell partitions were 3.49mm ± 0.28mm thick (n=15) at the margins, where they are thicker. X. grisescens visited 12 plant species (six families). The most frequently visited plant species were Senna Gardneri (Benth.) Irwin & Barneby (32%), S. macranthera (Collad.) Irwin & Barneby var. pudibunda (18%), Proterantha glandulosa sp. n. (15%) and Dioclea marginata Benth. (15%).Xylocopa (Neoxylocopa) grisescens Lepeletier, 1841 (Hymenoptera: Apidae: Xylocopini) foi a espécie mais abundante do gênero, amostrada nas flores, em uma área das dunas do médio Rio São Francisco. A arquitetura de cinco ninhos de X. grisescens construídos em galhos de Capparis sp. (Capparaceae) foi descrita. O comprimento e o diâmetro dos substratos dos ninhos variaram de 68-87cm e 17-23cm, respectivamente. Cada ninho apresenta uma entrada circular com diâmetro médio de 15,95 ± 1,08mm (n=7). As células possuem a forma de barril com 2,40 ± 0,18cm de comprimento, 2,01 ± 0,11cm de diâmetro e 7,59 ± 0,79cm3 de volume. As divisórias entre as células possuem, em media, 3,49 ± 0,28mm de espessura (n=15) medida na borda a qual é um pouco mais espessa do que o centro. X. grisescens visitou 12 espécies de plantas de seis famílias, mas concentaram suas atividades em apenas quatro espécies que receberam 80% das visitas: Senna gardneri (Benth.) Irwin & Barneby (32%), S. macranthera (Collad.) Irwin & Barneby var. pudibunda (18%), Proterantha glandulosa sp. n. (15%) e Dioclea marginata Benth. (15%)

Dynamical Breakdown of Symmetry in a (2+1) Dimensional Model Containing the Chern-Simons Field

We study the vacuum stability of a model of massless scalar and fermionic fields minimally coupled to a Chern-Simons field. The classical Lagrangian only involves dimensionless parameters, and the model can be thought as a (2+1) dimensional analog of the Coleman-Weinberg model. By calculating the effective potential, we show that dynamical symmetry breakdown occurs in the two-loop approximation. The vacuum becomes asymmetric and mass generation, for the boson and fermion fields takes place. Renormalization group arguments are used to clarify some aspects of the solution.Comment: Minor modifications in the text and figure

Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection

BACKGROUND: Chronic hepatitis C virus (HCV) infection of the liver with either genotype 1 or genotype 3 gives rise to distinct pathologies, and the two viral genotypes respond differently to antiviral therapy. METHODS: To understand these clinical differences, we compared gene transcription profiles in liver biopsies from patients infected with either gt1 or gt3, and uninfected controls. RESULTS: Gt1-infected biopsies displayed elevated levels of transcripts regulated by type I and type III interferons (IFN), including genes that predict response to IFN-α therapy. In contrast, genes controlled by IFN-γ were induced in gt3-infected biopsies. Moreover, IFN-γ levels were higher in gt3-infected biopsies. Analysis of hepatocyte-derived cell lines confirmed that the genes upregulated in gt3 infection were preferentially induced by IFN-γ. The transcriptional profile of gt3 infection was unaffected by IFNL4 polymorphisms, providing a rationale for the reduced predictive power of IFNL genotyping in gt3-infected patients. CONCLUSIONS: The interactions between HCV genotypes 1 and 3 and hepatocytes are distinct. These unique interactions provide avenues to explore the biological mechanisms that drive viral genotype-specific differences in disease progression and treatment response. A greater understanding of the distinct host-pathogen interactions of the different HCV genotypes is required to facilitate optimal management of HCV infection

Sri Lankan tsunami refugees: a cross sectional study of the relationships between housing conditions and self-reported health

BACKGROUND: On the 26th December 2004 the Asian tsunami devastated the Sri Lankan coastline. More than two years later, over 14,500 families were still living in transitional shelters. This study compares the health of the internally displaced people (IDP), living in transitional camps with those in permanent housing projects provided by government and non-government organisations in Sri Lanka. METHODS: This study was conducted in seven transitional camps and five permanent housing projects in the south west of Sri Lanka. Using an interviewer-led questionnaire, data on the IDPs' self-reported health and housing conditions were collected from 154 participants from transitional camps and 147 participants from permanent housing projects. Simple tabulation with non-parametric tests and logistic regression were used to identify and analyse relationships between housing conditions and the reported prevalence of specific symptoms. RESULTS: Analysis showed that living conditions were significantly worse in transitional camps than in permanent housing projects for all factors investigated, except 'having a leaking roof'. Transitional camp participants scored significantly lower on self-perceived overall health scores than those living in housing projects. After controlling for gender, age and marital status, living in a transitional camp compared to a housing project was found to be a significant risk factor for the following symptoms; coughs OR: 3.53 (CI: 2.11-5.89), stomach ache 4.82 (2.19-10.82), headache 5.20 (3.09-8.76), general aches and pains 6.44 (3.67-11.33) and feeling generally unwell 2.28 (2.51-7.29). Within transitional camp data, the only condition shown to be a significant risk factor for any symptom was household population density, which increased the risk of stomach aches 1.40 (1.09-1.79) and headaches 1.33 (1.01-1.77). CONCLUSION: Internally displaced people living in transitional camps are a vulnerable population and specific interventions need to be targeted at this population to address the health inequalities that they report to be experiencing. Further studies need to be conducted to establish which aspects of their housing environment predispose them to poorer health

Development of Potential Multi-Target Inhibitors for Human Cholinesterases and Beta-Secretase 1: A Computational Approach

Alzheimer’s disease causes chronic neurodegeneration and is the leading cause of dementia in the world. The causes of this disease are not fully understood but seem to involve two essential cerebral pathways: cholinergic and amyloid. The simultaneous inhibition of AChE, BuChE, and BACE-1, essential enzymes involved in those pathways, is a promising therapeutic approach to treat the symptoms and, hopefully, also halt the disease progression. This study sought to identify triple enzymatic inhibitors based on stereo-electronic requirements deduced from molecular modeling of AChE, BuChE, and BACE-1 active sites. A pharmacophore model was built, displaying four hydrophobic centers, three hydrogen bond acceptors, and one positively charged nitrogen, and used to prioritize molecules found in virtual libraries. Compounds showing adequate overlapping rates with the pharmacophore were subjected to molecular docking against the three enzymes and those with an adequate docking score (n = 12) were evaluated for physicochemical and toxicological parameters and commercial availability. The structure exhibiting the greatest inhibitory potential against all three enzymes was subjected to molecular dynamics simulations (100 ns) to assess the stability of the inhibitor-enzyme systems. The results of this in silico approach indicate ZINC1733 can be a potential multi-target inhibitor of AChE, BuChE, and BACE-1, and future enzymatic assays are planned to validate those results.PPBE and PPGCF/UEFS; Fundação de Amparo à Pesquisa do Estado de Minas Gerais—FAPEMIG, grants APQ-02741-17, APQ-00855-19, APQ-01733-21, and APQ-04559-22Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq-Brazil, grants 305117/2017-3, 426261/2018-6Fellowship of 2021 (grant 310108/2020-9